Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT

Autor: M H, Bridgland-Taylor, A C, Hargreaves, A, Easter, A, Orme, D C, Henthorn, M, Ding, A M, Davis, B G, Small, C G, Heapy, N, Abi-Gerges, F, Persson, I, Jacobson, M, Sullivan, N, Albertson, T G, Hammond, E, Sullivan, J-P, Valentin, C E, Pollard

Publikováno v: Journal of Pharmacological and Toxicological Methods. 54:189-199

Regulatory and competitive pressure to reduce the QT interval prolongation risk of potential new drugs has led to focus on methods to test for inhibition of the human ether-a-go-go-related gene (hERG)-encoded K+ channel, the primary molecular target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03365662b18fdce884939590e0b357f2
https://doi.org/10.1016/j.vascn.2006.02.003

Effects of small-particle aerosols of local anaesthetic on dyspnoea in patients with respiratory disease

Autor: T. B. Stretton, R.D. Stark, C. G. Heapy, N. J. W. Russell, PA O'Neill

Publikováno v: Clinical science (London, England : 1979). 69(1)

1. This study was devised to test the hypothesis that dyspnoea could be mediated by unmyelinated vagal sensory nerve endings (type J receptors) situated at alveolar level in the lung. 2. A modified jet nebulizer was used to generate an aerosol of loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1351b01eef6c8cd6ae051292fd6d3f5
https://pubmed.ncbi.nlm.nih.gov/3905207

The sensitivity to chemogenic stimuli of perivascular sensory receptors in the isolated perfused rabbit ear

Autor: C. G. Heapy, N. J.W. Russell, A. Jamieson

Publikováno v: Pain. 30:S279

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5cc13b38a0eb66c00f510dfbdf86748
https://doi.org/10.1016/0304-3959(87)91619-8

Synthesis and Analgesic Activity of 3-Arylamino-1,2-Dihydro-3 H-1,4-Benzodiazepin-2-Ones.

Autor: Pavlovskii, V.¹ victor_pavlovsky@ukr.net, Ushakov, I.¹, Kabanova, T.¹, Khalimova, E.¹, Kravtsov, V.² kravtsov@phys.asm.md, Andronati, S.¹ andronati_s@ukr.net

Publikováno v: Pharmaceutical Chemistry Journal. Dec2015, Vol. 49 Issue 9, p592-597. 6p.

A graphite furnace-atomic absorption spectrometry-based rubidium efflux assay for screening activators of the K v 7.2/3 channel.

Autor: Bartz FM; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, Greifswald, Germany., Beirow K; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, Greifswald, Germany., Wurm K; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, Greifswald, Germany., Baecker D; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, Greifswald, Germany., Link A; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, Greifswald, Germany., Bednarski PJ; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, Greifswald, Germany.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2023 May; Vol. 356 (5), pp. e2200585. Date of Electronic Publication: 2023 Feb 07.