Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

Autor: Jay M. Sosenko, D. J. Becker, Kevan C. Herold, E. Leschek, James W. Thomas, Francesco Dotta, Jeffrey L. Mahon, K. Nanto-Salonen, Diane K. Wherrett, Lisa M. Spain, Andrew Muir, Polly J. Bingley, Massimo Trucco, Jeffrey P. Krischer, S. E. Gitelman, Alessandra Mandelli, Mark S. Anderson, Sarah J. Richardson, Peter S. Linsley, Riccardo Bonfanti, Eleonora Bianconi, George S. Eisenbarth, M. Siegelman, J. Peyman, Angela Stabilini, M. Redondo, Bernhard J. Hering, Richard A. Insel, Maurizio De Pellegrin, Franco Meschi, Francesca Ragogna, Mark A. Clements, Lars Krogvold, Mark Peakman, Alberto Pugliese, J. Blum, William E. Russell, P. Chase, Pia Leete, Anette-Gabriele Ziegler, Mark A. Atkinson, Jane H. Buckner, Andrea Rigamonti, Tihamer Orban, Laura Nigi, Philip Raskin, Guido Sebastiani, Louis H. Philipson, Linda A. DiMeglio, Clara Bonura, Manuela Battaglia, Jay S. Skyler, David A. Baidal, Giulio Frontino, Emanuele Bosi, Matthew J. Dufort, Andrea Valle, William E. Winter, Peter A. Gottlieb, C. G. Fathman, Helena Elding Larsson, Robin Goland, Michael J. Clare-Salzler, M. G. Roncarolo, Raphael Clynes, Peter A. Antinozzi, Andrea K. Steck, Mikael Knip, Olli Simell, R. Parkman, Bart O. Roep, Desmond A. Schatz, Henry Rodriguez, Nicola Lo Buono, John M. Wentworth, Andrea Laurenzi, Francesca Mancarella, P. Savage, Jennifer B. Marks, G. Grave, Paola M.V. Rancoita, Federica Vecchio, Åke Lernmark, Darrell M. Wilson, Noel G. Morgan, Thomas W.H. Kay, Francine R. Kaufman, Federica Cugnata, Christophe Benoist, Susan Geyer, Peter G. Colman, Mark D. Pescovitz, Robert S. Sherwin, Gerald T. Nepom, John E. Wagner, Antoinette Moran, Knut Dahl-Jørgensen, Jerry P. Palmer, Kasia Bourcier, Wayne V. Moore, Carla J. Greenbaum, Pauline Grogan

BACKGROUND. Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while their role in human type 1 diabetes (T1D), a disease that progresses sequentially through identifiable stages prior to the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee5d8b12a49d70a6a58dc2174c69799

Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis

Autor: Garry P. Nolan, C Lin, Alenka Levicnik, C G Fathman, Marie A. Hollenhorst, Ingo H. Tarner, Richard Smith

Publikováno v: Gene Therapy. 10:1248-1257

Although systemic administration of neutralizing anti-TNF antibodies has been used successfully in treating rheumatoid arthritis, there is a potential for side effects. We transduced a collagen reactive T-cell hybridoma with tissue-specific homing pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0698f3ea9dcfd2f148050d0d1229aed3
https://doi.org/10.1038/sj.gt.3301980

Vitamin D Deficiency in a Multiethnic Healthy Control Cohort and Altered Immune Response in Vitamin D Deficient European-American Healthy Controls

Autor: C G Fathman, Diane L. Kamen, Hemangi B. Shah, Dustin A. Fife, R. Hal Scofield, Hongwu Du, Lauren L. Ritterhouse, Rufei Lu, Holden T. Maecker, Joel M. Guthridge, Judith A. James, Julie M. Robertson, Eliza F. Chakravarty

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e94500 (2014)

Objective In recent years, vitamin D has been shown to possess a wide range of immunomodulatory effects. Although there is extensive amount of research on vitamin D, we lack a comprehensive understanding of the prevalence of vitamin D deficiency or t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d920cc18618c2c1e4097552b0d8d49
http://europepmc.org/articles/PMC3984168

IDENTIFICATION AND CHARACTERIZATION OF THE ANTIGEN-SPECIFIC SUBPOPULATION OF ALLOREACTIVE CD4+ T CELLS IN VITRO AND IN VIVO1

Autor: C G Fathman, Nancy R. Krieger, Shaw Mk, William M. Ridgway

Publikováno v: Transplantation. 69:605-609

We report the identification and characterization of the small subpopulation of alloantigen-specific T cells in vitro and in vivo. This subpopulation of T cells was distinguished by up-regulation of cell surface CD4 expression. These CD4 high T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c150b8111e34cd6794524901966c9ecc
https://doi.org/10.1097/00007890-200002270-00023

A gene therapy approach to treatment of autoimmune disease

Autor: C G Fathman, Christine M. Seroogy

Publikováno v: Immunologic Research. 18:15-26

New insights into the underlying mechanisms for the development of autoimmune diseases in humans and various animal models continue to increase with our understanding of factors that drive polarization of T helper (Th) responses and tolerance. This i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae1ed22b2e6a9d1f4ffd30292f936b6
https://doi.org/10.1007/bf02786510