Zobrazeno 1 - 6
of 6
pro vyhledávání: '"C. G. Dealwis"'
Autor:
Steve P. Wood, Kieran F. Geoghegan, Peter M. Hobart, B. L. Sibanda, M. Badasso, C. G. Dealwis, M.P. Newman, B. A. O’Connor, C. Aguilar, Mark Ammirati, Dennis J. Hoover, Ian J. Tickle, Carlos Frazão, V. Dhanaraj, Dennis E. Danley, Tom L. Blundell, Jon B. Cooper, H.P.C. Driessen
Publikováno v:
Nature. 357:466-472
X-ray analyses have defined the three-dimensional structures of crystals of mouse and human renins complexed with peptide inhibitors at resolutions of 1.9 and 2.8 A, respectively. The exquisite specificity of renin arises partly from ordered loop reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3355ba138c0a02b4c22ffdeda71f5e
https://doi.org/10.1038/357466a0
https://doi.org/10.1038/357466a0
Autor:
Jon B. Cooper, P. Orprayoon, M.P. Newman, V. Dhanaraj, Tom L. Blundell, Philip Nugent, Dimitris Mantafounis, C. G. Dealwis, James E. Pitts
Publikováno v:
Scandinavian Journal of Clinical and Laboratory Investigation. 52:39-50
The specificity and pH profile of aspartic proteinases have evolved to include not only pepsin with a broad specificity and an optimal activity in acid media, but also renin, with high specificity for angiotensinogen and activity close to neutral pH.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb1925d2d78f47ead11c8a202b991dc
https://doi.org/10.3109/00365519209104653
https://doi.org/10.3109/00365519209104653
Autor:
Colin D. Flint, Dominique Maes, Rex A. Palmer, R. W. Janes, J. N. Lisgarten, D. M. Gazi, C. G. Dealwis
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 46:396-399
The crystal and molecular structure of trans-dichloro(1,4,8,11-tetraazacyclotetradecaneN,N',N'',N'')chromium(III) isothiocyanate has been determined. The cyclam (1,4,8,11-tetraazacyclotetradecane) moiety exists in a chair conformation located on a cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d13f4efe92b61b8bbd0ff188648374d
https://doi.org/10.1107/s0108270189011248
https://doi.org/10.1107/s0108270189011248
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 48:1754-1756
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36ea341a42dfdf37437d230ef6488a17
https://doi.org/10.1107/s0108270192000040
https://doi.org/10.1107/s0108270192000040
Autor:
Javier Sueiras-Diaz, Tom L. Blundell, Kazuo Murakami, Mark Ammirati, Jon B. Cooper, S.P. Wood, H. Miyazaki, Dennis E. Danley, M. Szelke, D. M. Jones, Peter M. Hobart, B. L. Sibanda, M. Badasso, C. G. Dealwis, Dennis J. Hoover, Carlos Frazão, V. Dhanaraj, A. J. Lanzetti, B. A. O’Connor, Kieran F. Geoghegan
Publikováno v:
Journal of molecular biology. 223(2)
Inhibitor-complexed crystals of mouse and human renins suitable for X-ray analysis have been prepared. The mouse renin is complexed with a non-hydrolysable decapeptide analogue of rat angiotensinogen containing a hydroxyethylene isostere in place of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75867b0f74d5914336a459b34a141cc0
https://pubmed.ncbi.nlm.nih.gov/1738157
https://pubmed.ncbi.nlm.nih.gov/1738157
Autor:
J E, Pitts, V, Dhanaraj, C G, Dealwis, D, Mantafounis, P, Nugent, P, Orprayoon, J B, Cooper, M, Newman, T L, Blundell
Publikováno v:
Scandinavian journal of clinical and laboratory investigation. Supplementum. 210
The specificity and pH profile of aspartic proteinases have evolved to include not only pepsin with a broad specificity and an optimal activity in acid media, but also renin, with high specificity for angiotensinogen and activity close to neutral pH.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d9bdb70cb16872cdb1283e0bc1be9dc
https://pubmed.ncbi.nlm.nih.gov/1455178
https://pubmed.ncbi.nlm.nih.gov/1455178