Zobrazeno 1 - 10
of 126
pro vyhledávání: '"C. G. D. Brook"'
SUMMARY A deconvolution analysis model to calculate pituitary growth hormone (GH) secretion rate from measured serum GH concentration has been developed. This uses an iterative method of‘curve-stripping’based on an estimate of the half-life. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9b4c0dcf422d6e7f8e51f36798f160
https://ora.ox.ac.uk/objects/uuid:7c872039-f9d6-4e67-a7bc-636637668f6b
https://ora.ox.ac.uk/objects/uuid:7c872039-f9d6-4e67-a7bc-636637668f6b
Autor:
Michael A. Preece, P. C. Hindmarsh, Joanne L. Jones, C. G. D. Brook, S. Saini, P. J. Pringle, David R. Matthews
SUMMARY objective To study the reproducibility of 24-h serum growth hormone (GH) concentration profiles in adults. DESIGN 24-h serum GH concentrations were constructed by drawing blood samples at 20-min Intervals. Four study occasions over a period o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4612ed837ebaeb215e61e1fee274a8d8
https://ora.ox.ac.uk/objects/uuid:7de7f9fb-67e7-4d34-915e-dc88b1941f5a
https://ora.ox.ac.uk/objects/uuid:7de7f9fb-67e7-4d34-915e-dc88b1941f5a
Autor:
J Wilshin, Michael Geary, P. J. Pringle, C. G. D. Brook, M Persaud, Charles H. Rodeck, Peter C. Hindmarsh
Publikováno v:
BJOG: An International Journal of Obstetrics and Gynaecology. 106:1054-1060
Objective To determine 1. the relationship between maternal serum leptin concentrations and maternal anthropometry and 2. the relationship between cord serum leptin concentrations at birth and neonatal anthropometry. Design Prospective cohort study o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd58b3e026adab902a8d74c3ab5d2a1
https://doi.org/10.1111/j.1471-0528.1999.tb08113.x
https://doi.org/10.1111/j.1471-0528.1999.tb08113.x
Autor:
E. Dennison, C. G. D. Brook, Cyrus Cooper, Peter C. Hindmarsh, Steven M. Pincus, P. J. Pringle, David R Matthews, C. H. D. Fall
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 84:2679-2685
In rodents, the sexually dimorphic pattern of pulsatile GH secretion is an important determinant of growth, liver enzyme function and insulin-like growth factor I (IGF-I) expression. Whether this difference is present in humans at different ages is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c8683af3fb9401c27c45148b4023d4
https://doi.org/10.1210/jcem.84.8.5915
https://doi.org/10.1210/jcem.84.8.5915
Autor:
Peter C. Hindmarsh, C. G. D. Brook
Publikováno v:
Acta Paediatrica. 88:66-69
Hindmarsh PC, Brook CGD. Evidence for an association between birth weight and blood pressure. Acta Paediatr 1999; Suppl 428: 66–9. Stockholm. ISSN 0803–5326 Evidence is presented to support the concept that there is an association between birth w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8397e8278931ba04a420cf667147c24c
https://doi.org/10.1111/j.1651-2227.1999.tb14354.x
https://doi.org/10.1111/j.1651-2227.1999.tb14354.x
Autor:
C. G. D. Brook
Publikováno v:
Developmental Medicine & Child Neurology. 19:78-80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b889df632aa98b3408d7c101f76142e2
https://doi.org/10.1111/j.1469-8749.1977.tb08026.x
https://doi.org/10.1111/j.1469-8749.1977.tb08026.x
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 83:3750-3753
The dose of 250 microg used in the standard short synacthen test is supraphysiological and lower doses may provide a more sensitive test. We examined steroid responses to 125ng/m2, 250ng/m2 and 500 ng/m2 (1-24)ACTH in 6 normal males, looking at effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd253765c0084f55eeb4d7f09a53fc3
https://doi.org/10.1210/jcem.83.10.5315
https://doi.org/10.1210/jcem.83.10.5315
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 82:2172-2176
GH is secreted in a pulsatile fashion, promoting growth and anabolism. The components of the pulsatile signal involved in these diverse effects are unclear. We constructed (20-min sampling interval) and analyzed 24-h serum GH profiles in 45 adult mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d8bbd66eea6d50f55475ec3f12df899
https://doi.org/10.1210/jcem.82.7.4036
https://doi.org/10.1210/jcem.82.7.4036
Publikováno v:
Journal of Endocrinology. 150:329-342
To determine the aetiopathology of post-irradiation growth hormone (GH) deficiency, we performed a mixed longitudinal analysis of 56 24 h serum GH concentration profiles and 45 paired insulin-induced hypoglycaemia tests (ITT) in 35 prepubertal childr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b17eea8dbc99371ffe56044bbc4b55d
https://doi.org/10.1677/joe.0.1500329
https://doi.org/10.1677/joe.0.1500329
Autor:
C. G. D. Brook, Harvey J. Guyda, Douglas Frazier, David B. Allen, P. C. Hindmarsh, N. A. Bridges
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 79:1239-1248
Rationing scarce pituitary-derived hGH required laboratory criteria which excluded all but the most severely GHdeficient (GHD). Although abundant recombinant DNAderived hGH now makes treatment of partialand non-GHD short children possible, pressures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ece11c068e03f79f22036aa5258e18e
https://doi.org/10.1210/jcem.79.5.7962315
https://doi.org/10.1210/jcem.79.5.7962315