Výsledky vyhledávání - "C. G. Chidester"

Synthesis of (r)- and (s)-1-formyl-6,7,8,9-tetrahydro-N,N-(dipropyl)-3H-benz[e]indol-8-amines: Potent and orally active 5-ht1areceptor agonists

Autor: N. B. Ghazal, Robert L. Hoffman, Michael D. Ennis, C. G. Chidester, Chiu-Hong Lin, G. Phillips, Susanne R. Haadsma-Svensson

Publikováno v: Journal of Heterocyclic Chemistry. 31:129-139

An efficient synthesis of the potent and orally active 5-HT 1A agonists, (R)-(+)- and (S)-(-)-1-formyl-6,7,8,9-tetrahydro-N,N-dipropyl-3H-benz[e]indol-8-amines 1a and 1b, is described. This synthesis was accomplished in twelve steps from commercially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a110d46c9abdbf752b2be4b7d995a71
https://doi.org/10.1002/jhet.5570310123

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Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro-3-propyl-1H-benz[e]indole-9-carboxamide: A potent and selective 5-HT1A receptor agonist with good oral availability

Autor: Robert B. McCall, G. Phillips, Chiu-Hong Lin, C. G. Chidester, Montford F. Piercey, Kjell A. Svensson, M. W. Smith, Susanne R. Haadsma-Svensson, P. F. Von Voigtlander, Arvid Carlsson

Publikováno v: Journal of Medicinal Chemistry. 36:2208-2218

The synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b- hexahydro-3-propyl-1H-benz[e]indole-9-carboxamide ((-)-3a), U93385, is described. The cis racemate and its enantiomer as well as the corresponding trans enantiomers were also synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d36e0beb2ab84b15d7a18c18bf89062
https://doi.org/10.1021/jm00067a018

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Comparison of 5-HT1A and dopamine D2 pharmacophores. X-ray structures and affinities of conformationally constrained ligands

Autor: Robert A. Lahti, M. W. Smith, C. G. Chidester, Chiu Hong Lin, Susanne R. Haadsma-Svensson

Publikováno v: Journal of Medicinal Chemistry. 36:1301-1315

Conformational and molecular mechanics studies of a new series of tricyclic ligands with affinity for either the dopamine D2 receptor or the 5-HT1A receptor, or both, has enabled us to elaborate considerably on previous pharmacophore models for these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19f1dca16de0da5ca3717523bbfacb7
https://doi.org/10.1021/jm00062a001

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Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives

Autor: Chiu-Hong Lin, Montford F. Piercey, Robert B. McCall, G. Phillips, P. F. Von Voigtlander, Robert A. Lahti, M. W. Smith, Susanne R. Haadsma-Svensson, P. J. K. D. Schreur, C. G. Chidester

Publikováno v: Journal of Medicinal Chemistry. 36:1069-1083

The conformationally restricted linear tricyclic analogs of 5- and 8-hydroxy-2-(di-n-propylamino)-tetralins were investigated for their serotonergic and dopaminergic properties. These cis and trans analogs of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0e3cef633462f8fec4b8202908241e
https://doi.org/10.1021/jm00060a015

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Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives

Autor: C H, Lin, S R, Haadsma-Svensson, R A, Lahti, R B, McCall, M F, Piercey, P J, Schreur, P F, Von Voigtlander, M W, Smith, C G, Chidester

Publikováno v: Journal of Medicinal Chemistry. 36:1053-1068

The synthesis and structure-activity relationships (SAR) of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives (3) are described. These compounds are conformationally restricted, angular tricyclic analogs of 2-aminotetralin. The synthesis was achie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915eed22f4246a6b69375ea3c44c52a9
https://doi.org/10.1021/jm00060a014

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ChemInform Abstract: trans-3,4-Diaminopiperidines. Azacyclohexane Congeners of kappa Agonist U-50488

Autor: Jacob Szmuszkovicz, Jeremiah P. Freeman, C. G. Chidester, Stan V. D'Andrea, E. T. Michalson

Publikováno v: ChemInform. 22

A variety of trans-3,4-diaminopiperidines were synthesized regio- and stereoselectively from 1-(carbobenzyloxy)-1,2,3,6-tetrahydropyridine. These compounds are structurally related to the selective κ agonist U-50488. The two key reactions which dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5614a181161f62a3260fe50bacd4833f
https://doi.org/10.1002/chin.199143144

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ChemInform Abstract: Synthesis of (R)- and (S)-1-Formyl-6,7,8,9-tetrahydro-N,N-(dipropyl)- 3H-benz(e)indol-8-amines: Potent and Orally Active 5-HT1A Receptor Agonists

Autor: N. B. Ghazal, Michael D. Ennis, Robert L. Hoffman, C. G. Chidester, Chiu-Hong Lin, Susanne R. Haadsma-Svensson, G. Phillips

Publikováno v: ChemInform. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ac14280c774c22e44e42a6c9391cb66
https://doi.org/10.1002/chin.199511144

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