Zobrazeno 1 - 10
of 17
pro vyhledávání: '"C. G. Bridges"'
Autor:
Daniel Schirlin, Debra L. Taylor, C. G. Bridges, P. S. Ahmed, J.-M. Hornsperger, Celine Tarnus, A. S. Tyms, V. Van Dorsselaer, T M Brennan
Publikováno v:
Antiviral Chemistry and Chemotherapy. 8:205-214
MDL 74,695, a novel dipeptide-like compound containing the ‘difluorostatone type’ transition state mimic and a potent inhibitor of the human immunodeficiency virus (HIV) proteinase, was investigated for anti-HIV activity in vitro. The compound sh
Autor:
J M Hornsperger, A. S. Tyms, J F Navé, C G Bridges, Debra Taylor, P Casara, P S Ahmed, T. M. Brennan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:1072-1077
The novel acyclonucleotide derivative of guanine, 9-[2-methylidene-3-(phosphonomethoxy)propyl] guanine (MDL 74,968), had antiviral activity comparable to those of 9-(2-phosphonomethoxyethyl) adenine (PMEA) and 2',3'-dideoxyinosine against laboratory
Publikováno v:
Antiviral Chemistry and Chemotherapy. 6:143-152
The anti-human immunodeficiency virus type 1 (HIV-1) activity of the α-glucosidase 1 inhibitor 6-0-butanoylcastanospermine (MDL 28574) was assessed in combination with the 2′,3′-dideoxynucleoside analogues zidovudine (AZT), didanosine (ddl) and
Publikováno v:
Antiviral Chemistry and Chemotherapy. 6:34-42
A novel low-molecular-weight sulfonic acid polymer, MDL 101028, was investigated for antiviral activity against herpes simplex virus (HSV) type 1 and type 2 in human embryonic diploid fibroblasts (MRC-5) and in a line of monkey kidney cells (Vero). P
Autor:
M. J. Mullins, A.S. Tyms, T M Brennan, R. L. Jackson, C G Bridges, Alan D. Cardin, D.L. Taylor
Publikováno v:
Antiviral research. 28(2)
MDL 101028, a novel biphenyl disulphonic acid urea co-polymer was designed and synthesised as a heparin mimetic. This low molecular weight polymer showed potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication in a number of host
Publikováno v:
Antiviral research. 27(4)
The ribonucleotide reductase inhibitor MDL 101,731 was examined for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro and in combination with acyclovir in the murine zosteriform model of HSV-1 infection. The i
Publikováno v:
Antiviral research. 26(2)
MKC-442, a derivative of the non-nucleoside reverse transcriptase (RT) inhibitor 1-[(2-hydroxyethoxy)methyl)-6-(phenylthio)thymidine (HEPT), showed potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro, u
Publikováno v:
Antimicrobial agents and chemotherapy. 38(8)
The 6-O-butanoyl derivative of castanospermine (MDL 28,574) was previously shown to be approximately 30-fold more potent than the naturally occurring molecule at inhibiting the replication of human immunodeficiency virus (HIV) (D. L. Taylor, P. S. Su
Publikováno v:
The Journal of general virology. 73
The polymerase chain reaction (PCR) and co-cultivation were used to identify the lymphoreticular system as the site of latency of equid herpesvirus I (EHV-1). Primers for PCR were designed from aligned nucleotide sequences of the glycoprotein gB gene
Autor:
C G, Bridges
Publikováno v:
Computer applications in the biosciences : CABIOS. 6(2)
A program to facilitate the design of oligonucleotide primers has been devised. Olga is written in draft ANSI standard 'C' and makes use of the implementation of Digital Research GEM (Graphics Environment Manager) on the Atari ST. Olga is specificall