Zobrazeno 1 - 10
of 27
pro vyhledávání: '"C. G. Benishin"'
Publikováno v:
Journal of Cardiovascular Pharmacology. 23:S23-S26
Publikováno v:
Canadian journal of physiology and pharmacology. 77(11)
Parathyroid hypertensive factor (PHF) has been implicated in regulation of vascular smooth muscle tone and pathogenesis of several forms of hypertension. Earlier studies have suggested that PHF enhances the actions of other vasoconstrictors, while it
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(1)
The present study was designed to investigate whether nitric oxide (NO) could interfere with intracellular Ca++ release through different pathways in vascular smooth muscle. Phasic contractions of rat aorta induced by phenylephrine or caffeine in Ca+
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(1)
In vascular smooth muscle cells (VSMCs) of rat tail artery, prostaglandin E2 (PGE2) inhibited a voltage-dependent, delayed rectifier K channel current (Ik). The inhibition was concentration-dependent, via a receptor-mediated mechanism involving the a
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(2)
There is evidence to suggest that PGE2 plays an important role in the regulation of vascular smooth muscle tone. To determine the cellular basis of this action, we studied the effect of PGE2 on force in helical muscle strips from rat tail artery. PGE
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 269(1)
beta-Dendrotoxin (beta-DTX), a polypeptide component of Eastern Green Mamba snake venom, inhibits a slow voltage-activated 86Rb efflux from synaptosomes, suggesting that beta-DTX inhibits K+ channels. The effects of beta-DTX on the K+ currents in pri
Publikováno v:
Journal of cardiovascular pharmacology. 23
Parathyroid hypertensive factor (PHF) has been purified from two sources of material: plasma of spontaneously hypertensive rats (SHRs) and culture medium from organ culture of SHR parathyroid glands. Chromatographic characteristics of PHF from these
Publikováno v:
Journal of hypertension. Supplement : official journal of the International Society of Hypertension. 12(1)
Parathyroid hypertensive factor (PHF) in rats: PHF is an endogenous hypertensive substance which was originally associated with hypertension in spontaneously hypertensive rats (SHR). In this model, PHF was shown to act by increasing intracellular cal
Publikováno v:
Journal of cardiovascular pharmacology. 23
The present studies investigated the effect of parathyroid hypertensive factor (PHF) on intracellular calcium regulation in VSMC. Nifedipine inhibited the hypertensive effect of PHF in Sprague-Dawley (SD) rats in vivo. PHF amplified the L-type calciu
Publikováno v:
Journal of cardiovascular pharmacology. 23
To determine the clinical significance of parathyroid hypertensive factor (PHF), physiological studies previously performed in animal models of hypertension were parallelled by human studies. These studies revealed that PHF-like activity is present i