Zobrazeno 1 - 10
of 168
pro vyhledávání: '"C. Fuscoe"'
Autor:
Varsha G. Desai, Ana Azevedo‐Pouly, Vikrant Vijay, Bounleut Phanavanh, Carrie L. Moland, Tao Han, Javier Revollo, Baikuntha Aryal, V. Ashutosh Rao, James C. Fuscoe
Publikováno v:
Journal of applied toxicology : JATREFERENCES.
Preclinical and clinical findings suggest sexual dimorphism in cardiotoxicity induced by a chemotherapeutic drug, doxorubicin (DOX). However, molecular alterations leading to sex-related differential vulnerability of heart to DOX toxicity are not ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0bd1f0db176887309be708f87aa962
https://pubmed.ncbi.nlm.nih.gov/36227756
https://pubmed.ncbi.nlm.nih.gov/36227756
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170813 (2017)
Stably Expressed Genes (SEGs) whose expression varies within a narrow range may be involved in core cellular processes necessary for basic functions. To identify such genes, we re-analyzed existing RNA-Seq gene expression profiles across 11 organs at
Externí odkaz:
https://doaj.org/article/48a679f094204767975ce800afa96979
Autor:
Yongxiang Zhao, Zhichao Liu, Jian He, Tieliu Shi, James C. Fuscoe, Xiangjun Ji, Jinghua Liu, Paweł P. Łabaj, Wenjun Bao, David P. Kreil, Geng Chen, Leming Shi, Peng Li, Liping Zhong, Baitang Ning, Wenzhong Xiao, Jun Wu, Weida Tong, Yong Huang, Huixiao Hong, Lei Guo
Publikováno v:
Nucleic Acids Research
The rat is an important model organism in biomedical research for studying human disease mechanisms and treatments, but its annotated transcriptome is far from complete. We constructed a Rat Transcriptome Re-annotation named RTR using RNA-seq data fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610fe15dc0b42532696c992c8518603c
http://europepmc.org/articles/PMC7470976
http://europepmc.org/articles/PMC7470976
Autor:
Varsha G. Desai, Vikrant Vijay, Taewon Lee, Tao Han, Carrie L. Moland, Bounleut Phanavanh, Eugene H. Herman, Kimo Stine, James C. Fuscoe
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 42(9)
Cardiotoxicity is a serious adverse effect of an anticancer drug, doxorubicin (DOX), which can occur within a year or decades after completion of therapy. The present study was designed to address a knowledge gap concerning a lack of circulating biom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f95bc67f2b3c49f1c203c200798e08
https://pubmed.ncbi.nlm.nih.gov/35199358
https://pubmed.ncbi.nlm.nih.gov/35199358
Autor:
Eugene Demchuk, Bruce A. Fowler, James C. Fuscoe, Richard D. Beger, Weida Tong, Jon G. Wilkes, Dan A. Buzatu, Weigong Ge, Laura K. Schnackenberg, Yunfeng Tie, Brooks McPhail, Huixiao Hong, Bruce A. Pearce
Publikováno v:
Molecules, Vol 17, Iss 3, Pp 3407-3460 (2012)
Polypharmacy increasingly has become a topic of public health concern, particularly as the U.S. population ages. Drug labels often contain insufficient information to enable the clinician to safely use multiple drugs. Because many of the drugs are bi
Externí odkaz:
https://doaj.org/article/7432f2b8eb01491c8a953e89d5ecdd3f
Autor:
Richard D. Beger, Eugene Demchuk, Bruce A. Fowler, Dan A. Buzatu, Jon G. Wilkes, Weida Tong, James C. Fuscoe, Luis G. Valerio, Huixiao Hong, Weigong Ge, Laura K. Schnackenberg, Bruce A. Pearce, Yunfeng Tie, Brooks McPhail
Publikováno v:
Molecules, Vol 17, Iss 3, Pp 3383-3406 (2012)
An interagency collaboration was established to model chemical interactions that may cause adverse health effects when an exposure to a mixture of chemicals occurs. Many of these chemicals—drugs, pesticides, and environmental pollutants—interact
Externí odkaz:
https://doaj.org/article/8f11c12aa2da430b93a8a091d93d82b8
Publikováno v:
Bioinformatics and Biology Insights, Vol 2, Pp 323-334 (2008)
Background: Bioassays are routinely used to evaluate the toxicity of test agents. Experimental designs for bioassays are largely encompassed by fixed effects linear models. In toxicogenomics studies where DNA arrays measure mRNA levels, the tissue sa
Externí odkaz:
https://doaj.org/article/e927c4dd156d44c885fd77da26df1b84
Autor:
Varsha G. Desai, Taewon Lee, Carrie L. Moland, Kelly Davis, Vikrant Vijay, Kimo C. Stine, James C. Fuscoe, Tao Han, Bounleut Phanavanh, Levan Muskhelishvili
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 42(5)
Subclinical cardiotoxicity at low total cumulative doxorubicin (DOX) doses can manifest into cardiomyopathy in long-term cancer survivors. However, the underlying mechanisms are poorly understood. In male B6C3F1 mice, assessment of cardiac function b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66081519ec4eb74d375c1461eb6621d7
https://pubmed.ncbi.nlm.nih.gov/34668590
https://pubmed.ncbi.nlm.nih.gov/34668590
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0117047 (2015)
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Moreover, sex and age are considered major risk factors in the development of CVDs. Mitochondria are vital for normal cardiac function, and regulation of mitochondrial structur
Externí odkaz:
https://doaj.org/article/53cfbb0cd6ab4d82bb07aee0f8b157b7
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75305 (2013)
Age is a predisposing condition for susceptibility to chronic kidney disease and progression as well as acute kidney injury that may arise due to the adverse effects of some drugs. Age-related differences in kidney biology, therefore, are a key conce
Externí odkaz:
https://doaj.org/article/0b9472c323f54218b1a985a04e0c7179