Zobrazeno 1 - 10
of 5 328
pro vyhledávání: '"C. Frank"'
Autor:
Moira A. McMahon, Meghdad Rahdar, Swagatam Mukhopadhyay, Huynh-Hoa Bui, Christopher Hart, Sagar Damle, Margo Courtney, Michael W. Baughn, Don W. Cleveland, C. Frank Bennett
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 289-301 (2023)
Antisense oligonucleotides (ASOs) are short synthetic nucleic acids that recognize and bind to complementary RNA to modulate gene expression. It is well established that single-stranded, phosphorothioate-modified ASOs enter cells independent of carri
Externí odkaz:
https://doaj.org/article/b4603aa807a3456aa6ae0c476b922870
Autor:
Kung-Chi Chang, Sarah D. Diermeier, Allen T. Yu, Lily D. Brine, Suzanne Russo, Sonam Bhatia, Habeeb Alsudani, Karen Kostroff, Tawfiqul Bhuiya, Edi Brogi, Darryl J. Pappin, C. Frank Bennett, Frank Rigo, David L. Spector
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
A group of long non-coding RNAs (lncRNAs), Mammary Tumor Associated RNA s 1-30 (MaTARs 1-30), are differentially expressed between mammary tumor cells and normal mammary epithelial cells. Here the authors report that MaTAR25 plays a role in breast ca
Externí odkaz:
https://doaj.org/article/6dafc61ca8e54b14af09f6dca2979a49
Autor:
Anixa Muiños-Bühl, Roman Rombo, Karen K. Ling, Eleonora Zilio, Frank Rigo, C. Frank Bennett, Brunhilde Wirth
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4198 (2023)
For SMA patients with only two SMN2 copies, available therapies might be insufficient to counteract lifelong motor neuron (MN) dysfunction. Therefore, additional SMN-independent compounds, supporting SMN-dependent therapies, might be beneficial. Neur
Externí odkaz:
https://doaj.org/article/f8dcd4a1f1744289b6058e6ec1b7380f
Autor:
Tracy A. Cole, Hien Zhao, Timothy J. Collier, Ivette Sandoval, Caryl E. Sortwell, Kathy Steece-Collier, Brian F. Daley, Alix Booms, Jack Lipton, Mackenzie Welch, Melissa Berman, Luke Jandreski, Danielle Graham, Andreas Weihofen, Stephanie Celano, Emily Schulz, Allyson Cole-Strauss, Esteban Luna, Duc Quach, Apoorva Mohan, C. Frank Bennett, Eric E. Swayze, Holly B. Kordasiewicz, Kelvin C. Luk, Katrina L. Paumier
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Parkinson’s disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations, and single nucleotide polymorphisms in the SNCA gene, encoding α-synuclein (aSyn) protein, either cause or
Externí odkaz:
https://doaj.org/article/d06ea6f3c76f4b97a20be199ac938389
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 313-325 (2019)
Splice-switching antisense oligonucleotides (ASOs) are promising therapeutic tools to target various genetic diseases, including cancer. However, in vivo delivery of ASOs to orthotopic tumors in cancer mouse models or to certain target tissues remain
Externí odkaz:
https://doaj.org/article/e178c55d3a444d6099f64f44b7a50fce
Autor:
Ningyan Hu, Layal Antoury, Timothy M. Baran, Soumya Mitra, C. Frank Bennett, Frank Rigo, Thomas H. Foster, Thurman M. Wheeler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Myotonic dystrophy type 1 (DM1) is associated with aberrant transcript splicing. Here, the authors develop a transgenic mouse model expressing a bi-chromatic reporter system that allows non-invasive monitoring of splicing of a transcript altered in D
Externí odkaz:
https://doaj.org/article/b1565fb81d1d487aac6b620c6b16e1b3
Autor:
Richard S. Nelson, C. Neal Stewart, Jiqing Gou, Susan Holladay, Lina Gallego-Giraldo, Amy Flanagan, David G. J. Mann, Hiroshi Hisano, Wegi A. Wuddineh, Charleson R. Poovaiah, Avinash Srivastava, Ajaya K. Biswal, Hui Shen, Luis L. Escamilla-Treviño, Jiading Yang, C. Frank Hardin, Rangaraj Nandakumar, Chunxiang Fu, Jiyi Zhang, Xirong Xiao, Ryan Percifield, Fang Chen, Jeffrey L. Bennetzen, Michael Udvardi, Mitra Mazarei, Richard A. Dixon, Zeng-Yu Wang, Yuhong Tang, Debra Mohnen, Brian H. Davison
Publikováno v:
Biotechnology for Biofuels, Vol 10, Iss 1, Pp 1-22 (2017)
Abstract Background The mission of the BioEnergy Science Center (BESC) was to enable efficient lignocellulosic-based biofuel production. One BESC goal was to decrease poplar and switchgrass biomass recalcitrance to biofuel conversion while not affect
Externí odkaz:
https://doaj.org/article/708f5185cc784eb08563cc78a63c5c56
Autor:
Dominic Jauvin, Jessina Chrétien, Sanjay K. Pandey, Laurie Martineau, Lucille Revillod, Guillaume Bassez, Aline Lachon, A. Robert McLeod, Geneviève Gourdon, Thurman M. Wheeler, Charles A. Thornton, C. Frank Bennett, Jack Puymirat
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 465-474 (2017)
Myotonic dystrophy type 1 (DM1), a dominant hereditary muscular dystrophy, is caused by an abnormal expansion of a (CTG)n trinucleotide repeat in the 3′ UTR of the human dystrophia myotonica protein kinase (DMPK) gene. As a consequence, mutant tran
Externí odkaz:
https://doaj.org/article/b019e0b86069472cbd72368b12dffd00
Autor:
Sarah D. Diermeier, Kung-Chi Chang, Susan M. Freier, Junyan Song, Osama El Demerdash, Alexander Krasnitz, Frank Rigo, C. Frank Bennett, David L. Spector
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 261-274 (2016)
Long non-coding RNAs (lncRNAs) represent the largest and most diverse class of non-coding RNAs, comprising almost 16,000 currently annotated transcripts in human and 10,000 in mouse. Here, we investigated the role of lncRNAs in mammary tumors by perf
Externí odkaz:
https://doaj.org/article/c2fa708b91c44e2c9a56c1372141076a
Autor:
Andrew P. Lieberman, Zhigang Yu, Sue Murray, Raechel Peralta, Audrey Low, Shuling Guo, Xing Xian Yu, Constanza J. Cortes, C. Frank Bennett, Brett P. Monia, Albert R. La Spada, Gene Hung
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 774-784 (2014)
Spinal and bulbar muscular atrophy (SBMA) is caused by the polyglutamine androgen receptor (polyQ-AR), a protein expressed by both lower motor neurons and skeletal muscle. Although viewed as a motor neuronopathy, data from patients and mouse models s
Externí odkaz:
https://doaj.org/article/362a686dbe4b43e48c2719a1d0ab43eb