Zobrazeno 1 - 10
of 389
pro vyhledávání: '"C. Flytzanis"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 331-342 (2022)
Advances in adeno-associated virus (AAV) engineering have provided exciting new tools for research and potential solutions for gene therapy. However, the lung has not received the same tailored engineering as other major targets of debilitating genet
Externí odkaz:
https://doaj.org/article/34281c0d1f9f4c3fb28db5522f5c8ccc
Autor:
Jai Woong Seo, Elizabeth S. Ingham, Lisa Mahakian, Spencer Tumbale, Bo Wu, Sadaf Aghevlian, Shahin Shams, Mo Baikoghli, Poorva Jain, Xiaozhe Ding, Nick Goeden, Tatyana Dobreva, Nicholas C. Flytzanis, Michael Chavez, Kratika Singhal, Ryan Leib, Michelle L. James, David J. Segal, R. Holland Cheng, Eduardo A. Silva, Viviana Gradinaru, Katherine W. Ferrara
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Adeno-associated viruses (AAVs) can be targeted in a tissue-specific manner, but their tissue accumulation cannot be assessed in a non-invasive manner. Here the authors conjugate a multivalent chelator labelled with Cu-64 to the surface of AAVs and i
Externí odkaz:
https://doaj.org/article/3bffb0cc262e4293b560a67f7e3c6fd9
Autor:
Miguel R. Chuapoco, Nicholas C. Flytzanis, Nick Goeden, J. Christopher Octeau, Kristina M. Roxas, Ken Y. Chan, Jon Scherrer, Janet Winchester, Roy J. Blackburn, Lillian J. Campos, Cynthia M. Arokiaraj, Timothy F. Miles, Min J. Jang, Julia Vendemiatti, Benjamin E. Deverman, James Pickel, Andrew S. Fox, Viviana Gradinaru
Adeno-associated viruses (AAVs) can enable robust and safe gene delivery to the mammalian central nervous system (CNS). While the scientific community has developed numerous neurotropic AAV variants for systemic gene-transfer to the rodent brain, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa752b987e8f89af2f958f76efad422b
https://doi.org/10.1101/2022.01.08.475342
https://doi.org/10.1101/2022.01.08.475342
Autor:
Poorva Jain, Eduardo A. Silva, Spencer K. Tumbale, Michelle L. James, Ryan D. Leib, Katherine W. Ferrara, Mo Baikoghli, Jai Woong Seo, Tatyana Dobreva, Michael Chavez, Bo Wu, David J. Segal, Nick Goeden, R. Holland Cheng, Lisa M. Mahakian, Kratika Singhal, Nicholas C. Flytzanis, Shahin Shams, Xiaozhe Ding, Elizabeth S. Ingham, Sadaf Aghevlian, Viviana Gradinaru
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Adeno-associated viruses (AAVs) are typically single-stranded deoxyribonucleic acid (ssDNA) encapsulated within 25-nm protein capsids. Recently, tissue-specific AAV capsids (e.g. PHP.eB) have been shown to enhance brain delivery in rodents via the LY
Autor:
V. Degiorgio, C. Flytzanis
Nonlinear optical materials play a pivotal role in the future evolution of nonlinear optics in general and its impact in technology and industrial applications in particular. The progress in nonlinear optics has been tremendous since the first demons
Autor:
Alexander Cummins, Nick Goeden, Nicholas C. Flytzanis, James Pickel, Viviana Gradinaru, David Goertsen
Genetic intervention is increasingly explored as a therapeutic option for debilitating disorders of the central nervous system. The safety and efficacy of gene therapies relies upon expressing a transgene in affected cells while minimizing off-target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17863f3fb83017f6cd00159379a9acf6
https://doi.org/10.1101/2020.06.16.152975
https://doi.org/10.1101/2020.06.16.152975
Autor:
David Goertsen, Nicholas C. Flytzanis, Nick Goeden, Miguel R. Chuapoco, Alexander Cummins, Yijing Chen, Yingying Fan, Qiangge Zhang, Jitendra Sharma, Yangyang Duan, Liping Wang, Guoping Feng, Yu Chen, Nancy Y. Ip, James Pickel, Viviana Gradinaru
Publikováno v:
Nature neuroscience. 25(1)
Genetic intervention is increasingly being explored as a therapeutic option for debilitating disorders of the central nervous system. The safety and efficacy of gene therapies rely upon expressing a transgene in affected cells while minimizing off-ta
Autor:
Jennifer B Treweek, Ken Y Chan, Nicholas C Flytzanis, Bin Yang, Benjamin E Deverman, Alon Greenbaum, Antti Lignell, Cheng Xiao, Long Cai, Mark S Ladinsky, Pamela J Bjorkman, Charless C Fowlkes, Viviana Gradinaru
To facilitate fine-scale phenotyping of whole specimens, we describe here a set of tissue fixation-embedding, detergent-clearing and staining protocols that can be used to transform excised organs and whole organisms into optically transparent sample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cbbb7b575282dbc203c1715b605717
https://doi.org/10.17504/protocols.io.8xehxje
https://doi.org/10.17504/protocols.io.8xehxje
Autor:
Irina M Shapiro, Albert W Cheng, Nicholas C Flytzanis, Michele Balsamo, John S Condeelis, Maja H Oktay, Christopher B Burge, Frank B Gertler
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002218 (2011)
Epithelial-mesenchymal transition (EMT), a mechanism important for embryonic development, plays a critical role during malignant transformation. While much is known about transcriptional regulation of EMT, alternative splicing of several genes has al
Externí odkaz:
https://doaj.org/article/1155c6be6fce4575882391d9737d933b
Autor:
Eleonora S. Imasheva, Timothy M. Wannier, Frances H. Arnold, Adam Z. Rosenthal, Janos K. Lanyi, R. Scott McIsaac, Sergei P. Balashov, Martin K. M. Engqvist, Nicholas C. Flytzanis, Viviana Gradinaru, Lukas Herwig
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
McIsaac, RS; Engqvist, MKM; Wannier, T; Rosenthal, AZ; Herwig, L; Flytzanis, NC; et al.(2014). Directed evolution of a far-red fluorescent rhodopsin. Proceedings of the National Academy of Sciences of the United States of America, 111(36), 13034-13039. doi: 10.1073/pnas.1413987111. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2ct5x0p3
McIsaac, RS; Engqvist, MKM; Wannier, T; Rosenthal, AZ; Herwig, L; Flytzanis, NC; et al.(2014). Directed evolution of a far-red fluorescent rhodopsin. Proceedings of the National Academy of Sciences of the United States of America, 111(36), 13034-13039. doi: 10.1073/pnas.1413987111. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2ct5x0p3
Microbial rhodopsins are a diverse group of photoactive transmembrane proteins found in all three domains of life. A member of this protein family, Archaerhodopsin-3 (Arch) of halobacterium Halorubrum sodomense, was recently shown to function as a fl