A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster

Autor: Hannah Jones, Jenny A Willis, Lucy C Firth, Carlo NG Giachello, Giorgio F Gilestro

Publikováno v: eLife, Vol 12 (2023)

Understanding how the brain encodes behaviour is the ultimate goal of neuroscience and the ability to objectively and reproducibly describe and quantify behaviour is a necessary milestone on this path. Recent technological progresses in machine learn

Externí odkaz: https://doaj.org/article/c2e15d5bb22943e993cde8f7a3c22d15

Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins

Autor: Dagmara Korona, Benedict Dirnberger, Carlo NG Giachello, Rayner ML Queiroz, Rebeka Popovic, Karin H Müller, David-Paul Minde, Michael J Deery, Glynnis Johnson, Lucy C Firth, Fergus G Earley, Steven Russell, Kathryn S Lilley

Publikováno v: eLife, Vol 11 (2022)

Drosophila nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that represent a target for insecticides. Peptide neurotoxins are known to block nAChRs by binding to their target subunits, however, a better understanding of this m

Externí odkaz: https://doaj.org/article/f69fc854d6124052b948b5593df54f7b

Neonatal leptin treatment reverses the bone-suppressive effects of maternal undernutrition in adult rat offspring

Autor: Elwyn C. Firth, Greg D. Gamble, Jillian Cornish, Mark H. Vickers

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract Alterations in the early life environment, including maternal undernutrition (UN) during pregnancy, can lead to increased risk of metabolic and cardiovascular disorders in offspring. Leptin treatment of neonates born to UN rats reverses the

Externí odkaz: https://doaj.org/article/f31aea6f1e2543d092f49a19d5703525

Clinicians' Views of Patient-initiated Follow-up in Head and Neck Cancer: a Qualitative Study to Inform the PETNECK2 Trial

Autor: A. Lorenc, M. Wells, T. Fulton-Lieuw, P. Nankivell, H. Mehanna, M. Jepson, A. Karwath, B. Main, C. Firth, C. Gaunt, C. Greaves, D. Moore, E. Watson, G. Gkoutos, G. Ozakinci, J. Wolstenholme, J. Dretzke, J. Brett, J. Duda, L. Matheson, L.-R. Cherrill, M. Calvert, P. Kiely, P. Gaunt, S. Chernbumroong, S. Mittal, S. Thomas, S. Winter, W. Wong

Publikováno v: Lorenc, A, Wells, M, Fulton-Lieuw, T, Nankivell, P, Mehanna, H & Jepson, M J 2022, ' Clinicians’ views of patient-initiated follow-up in head and neck cancer : A qualitative study to inform the PETNECK2 trial ', Clinical Oncology, vol. 34, no. 4, pp. 230-240 . https://doi.org/10.1016/j.clon.2021.11.010

Aims: Current follow-up for head and neck cancer (HNC) is ineffective, expensive and fails to address patients' needs. The PETNECK2 trial will compare a new model of patient-initiated follow-up (PIFU) with routine scheduled follow-up. This article re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6834e201611fa44bf7af50578b1b00e
https://doi.org/10.1016/j.clon.2021.11.010

Conceptualising and Understanding Artistic Creativity in the Dementias: Interdisciplinary Approaches to Research and Practise

Autor: Paul M. Camic, Sebastian J. Crutch, Charlie Murphy, Nicholas C. Firth, Emma Harding, Charles R. Harrison, Susannah Howard, Sarah Strohmaier, Janneke Van Leewen, Julian West, Gill Windle, Selina Wray, Hannah Zeilig

Publikováno v: Frontiers in Psychology, Vol 9 (2018)

Creativity research has a substantial history in psychology and related disciplines; one component of this research tradition has specifically examined artistic creativity. Creativity theories have tended to concentrate, however, on creativity as an

Externí odkaz: https://doaj.org/article/1e3357e2e8234c06b84fa66ed4fc10a2