Zobrazeno 1 - 10
of 150
pro vyhledávání: '"C. Faux"'
Autor:
L. Mahrik, B. Stefanovie, A. Maresova, J. Princova, P. Kolesar, E. Lelkes, C. Faux, D. Helmlinger, M. Prevorovsky, J. J. Palecek
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Background Structural Maintenance of Chromosomes (SMC) complexes are molecular machines driving chromatin organization at higher levels. In eukaryotes, three SMC complexes (cohesin, condensin and SMC5/6) play key roles in cohesion, condensat
Externí odkaz:
https://doaj.org/article/24ffe04dca22490da5094abc51bec914
Autor:
Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C. Chüeh, Judy Doherty, François Vaillant, Gwo-Yaw Ho, Matthew J. Wakefield, Clare E. Weeden, Alvin Kamili, Jayne Murray, Sela T. Po’uha, Janet Weinstock, Serena R. Kane, Maree C. Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J. Kershaw, Chin Wee Tan, Helen M. Witchard, Gregor Ebert, Susan A. Charman, Ian Street, Maria Kavallaris, Michelle Haber, Jamie I. Fletcher, Marie-Liesse Asselin-Labat, Clare L. Scott, Jane E. Visvader, Geoffrey J. Lindeman, Keith G. Watson, Antony W. Burgess, Guillaume Lessene
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-18 (2021)
Abstract Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limitations of many standard-of-care chemotherapies: undesirable drug toxicity, side-effects, resistance and high cos
Externí odkaz:
https://doaj.org/article/041aa5232fd84ed8be1a33555359e8d7
Autor:
Ryan F. Leung, Ankita M. George, Enola M. Roussel, Maree C. Faux, Jeffrey T. Wigle, David D. Eisenstat
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Forebrain development in vertebrates is regulated by transcription factors encoded by homeobox, bHLH and forkhead gene families throughout the progressive and overlapping stages of neural induction and patterning, regional specification and generatio
Externí odkaz:
https://doaj.org/article/a2ab1209f1f84256818f9f22cae93f25
Autor:
Andre L. Samson, Ying Zhang, Niall D. Geoghegan, Xavier J. Gavin, Katherine A. Davies, Michael J. Mlodzianoski, Lachlan W. Whitehead, Daniel Frank, Sarah E. Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N. Young, Annette V. Jacobsen, Wayne Cawthorne, Emma J. Petrie, Maree C. Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M. Hildebrand, John Silke, Kelly L. Rogers, Guillaume Lessene, Edwin D. Hawkins, James M. Murphy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that accumul
Externí odkaz:
https://doaj.org/article/1ae829760f7e467a8e81c5fd0160cbfe
Autor:
Lauren E King, Hui-Hua Zhang, Cathryn M Gould, Daniel W Thomas, Lachlan W Whitehead, Kaylene J Simpson, Antony W Burgess, Maree C Faux
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240746 (2020)
Truncating mutations in the tumour suppressor gene APC occur frequently in colorectal cancers and result in the deregulation of Wnt signalling as well as changes in cell-cell adhesion. Using quantitative imaging based on the detection of membrane-ass
Externí odkaz:
https://doaj.org/article/7ccc7a1d2991414e8d11a93d8fa2e075
Autor:
Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. Santos, Kate GR. Quinlan, Nigel Turner, Daniel J. Fazakerley, Naresh Kumar, Kyle L. Hoehn
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
A hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical library screening approach to identify molecules that
Externí odkaz:
https://doaj.org/article/5e4c5baf666144d5a43fe60f14c4e6fb
Autor:
Antony W. Burgess, Michael Buchert, Tracy L. Putoczki, Michael Christie, Adele Preaudet, Matthias Ernst, Alexandra L. Garnham, Yasmin Cathcart-King, Ryan O'Keefe, Alexander I. Azimpour, Emma Prato, Sophia Gogos, Janet Weinstock, Maree C. Faux
Adenomatous polyposis coli (APC) truncations occur in many colorectal cancers and are often associated with immune infiltration. The aim of this study was to determine whether a combination of Wnt inhibition with anti-inflammatory (sulindac) and/or p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559f1f22ec0a9aad6d8ceba6e7cabdbe
https://doi.org/10.1158/2767-9764.c.6550616
https://doi.org/10.1158/2767-9764.c.6550616
Autor:
Antony W. Burgess, Michael Buchert, Tracy L. Putoczki, Michael Christie, Adele Preaudet, Matthias Ernst, Alexandra L. Garnham, Yasmin Cathcart-King, Ryan O'Keefe, Alexander I. Azimpour, Emma Prato, Sophia Gogos, Janet Weinstock, Maree C. Faux
Adenoma tumour development in Apcmin/+ and Dclk1Cre/+;Apcfl/fl mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f625be9842338c3ee28539c446308a
https://doi.org/10.1158/2767-9764.22544357.v1
https://doi.org/10.1158/2767-9764.22544357.v1
Autor:
Oliver M. Sieber, Elizabeth Vincan, Dustin J. Flanagan, Bruno Catimel, Nicole Church, Maree C. Faux, Francesca Walker, Richard J. Simpson, Oliver K. Bernhard, Ian P. M. Tomlinson, Stefania Segditsas, Simon J. Leedham, Richard Poulsom, Rosemary E. Jeffery, Matthias Ernst, Toby J. Phesse, Robert G. Ramsay, Jordane Malaterre, Lara Lipton, Peter Gibbs, Nicholas I. Fleming, Shan Li, Robert N. Jorissen, Cary Tsui, Carla D'Andreti, Michael Christie, Anuratha Sakthianandeswaren
Supplementary Methods and Materials from PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa290b79e392bf579e7e1eaa9a06c64
https://doi.org/10.1158/0008-5472.22388882
https://doi.org/10.1158/0008-5472.22388882
Autor:
Oliver M. Sieber, Elizabeth Vincan, Dustin J. Flanagan, Bruno Catimel, Nicole Church, Maree C. Faux, Francesca Walker, Richard J. Simpson, Oliver K. Bernhard, Ian P. M. Tomlinson, Stefania Segditsas, Simon J. Leedham, Richard Poulsom, Rosemary E. Jeffery, Matthias Ernst, Toby J. Phesse, Robert G. Ramsay, Jordane Malaterre, Lara Lipton, Peter Gibbs, Nicholas I. Fleming, Shan Li, Robert N. Jorissen, Cary Tsui, Carla D'Andreti, Michael Christie, Anuratha Sakthianandeswaren
Supplementary Figures 1-3 from PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204443ef038e79055d7e807ea5d4cf2c
https://doi.org/10.1158/0008-5472.22388885
https://doi.org/10.1158/0008-5472.22388885