Zobrazeno 1 - 10
of 38
pro vyhledávání: '"C. F. van Kreijl"'
Autor:
C. F. Van Kreijl, Rudolph B. Beems, H. van Steeg, J.C. Klein, M. Hamzink, P.E. Zwart, G. Zomer
Publikováno v:
Carcinogenesis. 22:619-626
The effects of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in DNA repair deficient XPA(-/-) mice. The nullizygous XPA-knockout mice, which lack a functional nucleotide excision repair (NER) pathway, were expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5079abf86d789c2ce40103888b71e4a
https://doi.org/10.1093/carcin/22.4.619
https://doi.org/10.1093/carcin/22.4.619
Publikováno v:
Toxicologic Pathology. 26:742-749
At present (putative) human carcinogens are identified via epidemiological studies and testing using the chronic 2-yr rodent bioassay. Both methods have severe limitations in that they are slow, insensitive, expensive, and are also hampered by many u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ddb5a6849af6500abf05828dd5f1f2b
https://doi.org/10.1177/019262339802600605
https://doi.org/10.1177/019262339802600605
Autor:
Richard D. Storer, E. D. Kroese, C. W. Van Der Houven Van Oordt, C. F. Van Kreijl, M. L. Breuer, Ilona Kryspin Sørensen
Publikováno v:
Europe PubMed Central
The value of the chronic rodent carcinogenicity assay in adequately predicting cancer risk in humans has become a matter of debate over the past few years. Therefore, more rapid and accurate alternative tests are urgently needed. Transgenic mouse mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c1b8a89f288c178fa6697056ccffb2
https://doi.org/10.1177/019262339802600606
https://doi.org/10.1177/019262339802600606
Autor:
H. van Steeg, C. F. Van Kreijl, Peter J.A. Capel, Anja Westerman, P. W. Wester, F.R. de Gruijl, R. J. W. Berg, Susan W.P. Wijnhoven, H.J. van Kranen, A. De Vries
Publikováno v:
Oncogene. 16:2205-2212
Xeroderma pigmentosum (XP) patients with a defect in the nucleotide excision repair gene XPA, develop tumors with a high frequency on sun-exposed areas of the skin. Here we describe that hairless XPA-deficient mice also develop skin tumors with a sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84b41054983eb9ad8a278a28e75350e
https://doi.org/10.1038/sj.onc.1201744
https://doi.org/10.1038/sj.onc.1201744
Autor:
H. van Steeg, J. J. A. Muller, Peter J.A. Capel, J. L. M. Broekhof, Martijn E.T. Dollé, E. D. Kroese, C. F. Van Kreijl, A. De Vries, Jan Vijg
Publikováno v:
Carcinogenesis. 18:2327-2332
We were interested to study the relationship between DNA lesions, DNA repair, mutation fixation, and tumour development. Therefore, mice harbouring lacZ reporter genes and being either wild-type or defective in the DNA excision repair gene XPA, were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c6252e36772707c810a4c71821032a
https://doi.org/10.1093/carcin/18.12.2327
https://doi.org/10.1093/carcin/18.12.2327
Autor:
R. J. W. Berg, A. De Vries, F.R. de Gruijl, C. F. Van Kreijl, Nicolas Dumaz, P. W. Wester, H.J. van Kranen, Leela Daya-Grosjean, Alain Sarasin
Publikováno v:
Carcinogenesis. 18:897-904
Mutation spectra of the p53 gene from human skin carcin- process that involves many modifications including proto-omas have been connected to solar UV radiation. For oncogenes and tumor suppressor genes. Among these, the p53comparison we have charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac77eacf71fd3429dcd14b1a3c251659
https://doi.org/10.1093/carcin/18.5.897
https://doi.org/10.1093/carcin/18.5.897
Autor:
A. De Vries, H.J. van Kranen, H. C. M. Senden, F.R. de Gruijl, Y. Sontag, E. Rozemuller, C. F. Van Kreijl, P. W. Wester
Publikováno v:
Carcinogenesis. 16:1141-1147
We have investigated UV-B-induced skin tumors of hairless SKH-HRA mice for alterations in the p53 gene and for mutations in either of the three ras genes. Out of 32 tumors screened, only one contained a ras mutation, i.e. in codon 12 of the K-ras gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40a0481c53c9957f507c68783f5459b
https://doi.org/10.1093/carcin/16.5.1141
https://doi.org/10.1093/carcin/16.5.1141
Autor:
Stephen S. Hecht, Mao-Jung Lee, Lilian U. Thompson, Henk J. van Kranen, Chung S. Yang, Jie Liao, Anthony T. Diplock, Beatrix L. Pool‐Zobel, Sungbin Kim, Gerhard Rechkemmer, C. F. Van Kreijl, Guang Yu Yang, Takuji Tanaka, Jee Chung
Publikováno v:
Carcinogenic and Anticarcinogenic Factors in Food: Symposium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b203a1f0f71492ee6c87cf44c8c61e2
https://doi.org/10.1002/3527606246.ch3d
https://doi.org/10.1002/3527606246.ch3d
Autor:
C F, van Kreijl, P A, McAnulty, R B, Beems, A, Vynckier, H, van Steeg, R, Fransson-Steen, C L, Alden, R, Forster, J W, van der Laan, J, Vandenberghe
Publikováno v:
Toxicologic pathology.
DNA repair deficient Xpa-/- and Xpa-/-/p53+/- knock-out mice in a C57BL/6 genetic background, referred to as respectively the XPA and XPA/p53 model, were investigated in the international collaborative research program coordinated by International Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f3f7ca1283c915a5ef3ac23efefd32e
https://pubmed.ncbi.nlm.nih.gov/11695547
https://pubmed.ncbi.nlm.nih.gov/11695547
Autor:
C T, van Oostrom, M, Boeve, J, van Den Berg, A, de Vries, M E, Dollé, R B, Beems, C F, van Kreijl, J, Vijg, H, van Steeg
Publikováno v:
Environmental and molecular mutagenesis. 34(2-3)
XPA-deficient mice have a complete deficiency in nucleotide excision repair, and as such they display a cancer predisposition after exposure to several carcinogens. Besides being sensitive to genotoxic agents applied to the skin, they are also suscep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::663986e83beaf9d035918d7b1b552487
https://pubmed.ncbi.nlm.nih.gov/10529736
https://pubmed.ncbi.nlm.nih.gov/10529736