Zobrazeno 1 - 10
of 18
pro vyhledávání: '"C. F. Snook"'
Autor:
Iyad Sultan, Rosalie C. Sears, Archana Mukhopadhyay, Pengfei Song, Besim Ogretmen, Yusuf A. Hannun, Can E. Senkal, Sahar A. Saddoughi, C. F. Snook, Suriyan Ponnusamy, Hugh Arnold
Publikováno v:
The FASEB Journal. 23:751-763
In this study, the inhibitor 2 of protein phosphatase 2A (I2PP2A) was identified in vitro and in situ as a ceramide-binding protein, which exhibits stereoisomer specificity and fatty acid chain length preference. Site- directed mutagenesis coupled wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdfd08770c090b37818247e7045d87e
https://doi.org/10.1096/fj.08-120550
https://doi.org/10.1096/fj.08-120550
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 3, Pp 600-608 (2007)
Ceramidases (CDases) hydrolyze ceramide to sphin- gosine (SPH) and fatty acid. Pseudomonas CDase (pCDase) is a homolog of mammalian neutral ceramidases and may play roles in disease pathogenesis. In this study, pCDase was cloned and expressed in Esch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e28723b0987a0472999c38121bfd0e2
http://www.sciencedirect.com/science/article/pii/S0022227520432353
http://www.sciencedirect.com/science/article/pii/S0022227520432353
Autor:
Nabil Matmati, Motohiro Tani, Yusuf A. Hannun, Christopher J. Clarke, C. F. Snook, Norma Marchesini
Publikováno v:
Biochemistry. 45:11247-11256
The neutral sphingomyelinases (N-SMases) are considered major candidates for mediating the stress-induced production of ceramide, and N-SMase activity has been identified, characterized, and cloned from bacteria, yeast, and mammalian cells. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9054145aba607c37568981538c9704c
https://doi.org/10.1021/bi061307z
https://doi.org/10.1021/bi061307z
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1761:927-946
Emerging information on sphingolipid metabolism and signaling is leading to a better understanding of cellular processes such as apoptosis, cancer, cell survival and aging. In this review, we discuss the involvement of sphingolipids in these processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d85dc83a738c5a0db821b2f9e2ea40
https://doi.org/10.1016/j.bbalip.2006.06.004
https://doi.org/10.1016/j.bbalip.2006.06.004
Publikováno v:
Biochemistry. 42:4658-4668
The enzyme GMD from Pseudomonas aeruginosa catalyzes the committed step in the synthesis of the exopolysaccharide alginate. Alginate is a major component of P. aeruginosa biofilms that protect the bacteria from the host immune response and antibiotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ada9d277660090c20d579503a8a2b1
https://doi.org/10.1021/bi027328k
https://doi.org/10.1021/bi027328k
Publikováno v:
Journal of Applied Crystallography. 33:344-349
A commercial crystallization robot has been modified for use in setting up sitting-drop vapor-diffusion crystallization experiments, and for setting up protein crystallization screensin situ. The primary aim of this effort is the automated screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81882398d488a7cbfdc0b226fa8c2c1a
https://doi.org/10.1107/s0021889800001151
https://doi.org/10.1107/s0021889800001151
Autor:
Bonnie A. Wallace, C. F. Snook
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 55:1539-1545
The successful use of molecular-replacement methods for the solution of the intermediate-sized helical polypeptide antiamoebin I required the careful consideration of a number of parameters and exhibited some unusual characteristics when compared wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d591f3899d3f43a0c37d37d50e444c
https://doi.org/10.1107/s0907444999007921
https://doi.org/10.1107/s0907444999007921
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1415:255-260
Antiamoebin is a 16-residue polypeptide whose crystal structure and lytic activity in membrane vesicles have recently been reported. It is a bent helical molecule and a member of the peptaibol family of antibiotics. Under conditions which produce vol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835329d9518d63209cc72740ce6da56d
https://doi.org/10.1016/s0005-2736(98)00184-9
https://doi.org/10.1016/s0005-2736(98)00184-9
Autor:
Charles A. Laughton, C. F. Snook, David F. Burke, Michael Jarman, Gerard A. Potter, Stephen Neidle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1125-1130
17-(3-pyridyl)androsta-5,16-dien-3β-ol, a nanomolar inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase, is a target for prostate cancer chemotherapy. A model is presented for the inhibitor docked into the structure of the enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cacba9c6c5b9e343c786114385eaf0e3
https://doi.org/10.1016/0960-894x(95)00178-v
https://doi.org/10.1016/0960-894x(95)00178-v
ChemInform Abstract: Derivatives of 2′,3′-Dithiouridine and (1-β-D-(2,3- Dithioxylofuranosyl))uracil
Publikováno v:
ChemInform. 24
The synthesis of 2′,3′-di-(4-tolylthio)uridine ( 5 ) and {1- β -(=D)-[2,3-di-(4-tolylthio)xylofuranosyl]}uracil ( 7 ) from (1- β -(=D)-lyxofuranosyl)uracil ( 3 ) and uridine, respectively, is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f6bac4814d7b3e209935704e7a1e6af
https://doi.org/10.1002/chin.199326235
https://doi.org/10.1002/chin.199326235