Výsledky vyhledávání - "C. F. Barker"

Tracking alloreactive cell division in vivo

Autor: H K, Song, H, Noorchashm, Y K, Lieu, S, Rostami, S A, Greeley, C F, Barker, A, Naji

Publikováno v: Transplantation. 68(2)

The study of alloimmune responses has been limited by a lack of assays that can track the behavior of alloreactive lymphocytes in vivo. Here we utilize an experimental system that allows the identification and study of alloreactive CD4+ lymphocytes r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0eef2488ae851eff66b2ba49295d17d5
https://pubmed.ncbi.nlm.nih.gov/10440405

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Origin, kinetics, and function of chimeric B lymphocytes in liver allografts

Autor: Y, Yokoi, H, Noorchashm, S Y, Rostami, C F, Barker, A, Naji

Publikováno v: Transplantation. 68(1)

Despite the well-recognized concordance of chimerism with spontaneous acceptance of rat liver allografts, the active role and the identity of chimeric cells mediating liver allograft tolerance are unknown. Because resting B cells are endowed with a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08d3f7161314b70e0ee4cc2a883d60b8
https://pubmed.ncbi.nlm.nih.gov/10428278

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Cardiac allograft tolerance induced by intra-arterial infusion of recombinant adenoviral CTLA4Ig

Autor: Z, Yang, S, Rostami, B, Koeberlein, C F, Barker, A, Naji

Publikováno v: Transplantation. 67(12)

Systemic administration of soluble recombinant fusion protein of cytotoxic T lymphocyte antigen 4 (CTLA4Ig) induces blockade of the CD28/B7 costimulatory pathway and promotes survival of allogeneic and xenogeneic grafts. We tested the efficacy of loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::704be6623f90e0170e54ee342aab5e71
https://pubmed.ncbi.nlm.nih.gov/10401757

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I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice

Autor: H, Noorchashm, Y K, Lieu, N, Noorchashm, S Y, Rostami, S A, Greeley, A, Schlachterman, H K, Song, L E, Noto, A M, Jevnikar, C F, Barker, A, Naji

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(2)

B cell-deficient nonobese diabetic (NOD) mice are protected from the development of spontaneous autoimmune diabetes, suggesting a requisite role for Ag presentation by B lymphocytes for the activation of a diabetogenic T cell repertoire. This study s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5c6549c345d046183aab8e03b8e41ad7
https://pubmed.ncbi.nlm.nih.gov/10395666

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A direct method for the calculation of alloreactive CD4+ T cell precursor frequency

Autor: H, Noorchashm, Y K, Lieu, S Y, Rostami, H K, Song, S A, Greeley, S, Bazel, C F, Barker, A, Naji

Publikováno v: Transplantation. 67(9)

Direct measurement of the precursor frequency of alloreactive CD4+ T cells has been impossible due to the lack of a specific means of determining the absolute number of daughter cells generated with each division in a repertoire of stimulated T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5d1b9daa6cbceb90e481174398f3ed1
https://pubmed.ncbi.nlm.nih.gov/10342323

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Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival

Autor: T A, Judge, N M, Desai, Z, Yang, S, Rostami, L, Alonso, H, Zhang, Y, Chen, J F, Markman, R P, DeMateo, C F, Barker, A, Naji, L A, Turka

Publikováno v: Transplantation. 66(4)

One of the best-defined mechanisms for the induction of apoptosis involves signaling via the cell surface molecule Fas, after binding of Fas ligand. Expression of Fas ligand is tightly regulated, being expressed primarily by T cells after activation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0630ec91eb3e34a8eb693e57aaa8f574
https://pubmed.ncbi.nlm.nih.gov/9734483

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Immunologic barriers to hepatic adenoviral gene therapy for transplantation

Autor: R P, DeMatteo, G, Chu, M, Ahn, E, Chang, C, Burke, S E, Raper, C F, Barker, J F, Markmann

Publikováno v: Transplantation. 63(2)

Adenoviral gene transfer has potential use to attenuate the immunogenicity of hepatic allografts. However, the clinical application of adenoviral gene therapy is currently impeded by the potent host immune response to the virus that limits the durati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71fb5727889c0b3e89a50b7564e5bd17
https://pubmed.ncbi.nlm.nih.gov/9020337

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