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Akademický článek

Vital signs and impaired cognition in older emergency department patients: The APOP study.

Autor: Jacinta A Lucke, Jelle de Gelder, Laura C Blomaard, Christian Heringhaus, Jelmer Alsma, Stephanie C E Klein Nagelvoort Schuit, Anniek Brink, Sander Anten, Gerard J Blauw, Bas de Groot, Simon P Mooijaart

Publikováno v: PLoS ONE, Vol 14, Iss 6, p e0218596 (2019)

Background/objectivesCognitive impairment is a frequent problem among older patients attending the Emergency Department (ED) and can be the result of pre-existing cognitive impairment, delirium, or neurologic disorders. Another cause can also be acut

Externí odkaz: https://doaj.org/article/2501a1d6788e4c8b83c9a3b4c71733ab

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Akademický článek

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Akademický článek

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A 45-year-old woman with an anticholinergic toxidrome

Autor: N A F, Verheijden, B C, Koch, Z, Brkic, J, Alsma, S C E, Klein Nagelvoort-Schuit

Publikováno v: The Netherlands journal of medicine. 74(3)

Intentional or accidental intoxications are common in the emergency department, but are not always sufficiently recognised. When intoxication is suspected, the causative agent or combination of agents often remain unclear, making these patients a dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0daefe9525b4ed6cbd9b73e6d3b0b74
https://pubmed.ncbi.nlm.nih.gov/27020994

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Tissue Inhibitor of Matrix Metalloproteinase-2 Regulates Matrix Metalloproteinase-2 Activation by Modulation of Membrane-type 1 Matrix Metalloproteinase Activity in High and Low Invasive Melanoma Cell Lines

Autor: C E Klein, Peter Kurschat, Cornelia Mauch, Roswitha Nischt, P Steurer, Katja Breitkopf, Paola Zigrino, Thomas Krieg

Publikováno v: Journal of Biological Chemistry. 274:21056-21062

Activation of pro-matrix metalloproteinase (MMP)-2 on the surface of malignant cells by membrane-bound MT1-MMP is believed to play a critical role during tumor progression and metastasis. In this study we present evidence that MT1-MMP plays a key rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58d43866beac5f5c035be5923681f3e
https://doi.org/10.1074/jbc.274.30.21056

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The role of genetic instability, adhesion, cell motility, and immune escape mechanisms in melanoma progression

Autor: Jürgen C. Becker, Thomas M. Rünger, Eva-Bettina Bröcker, C E Klein

Publikováno v: Current Opinion in Oncology. 6:188-196

Advances in different fields of research have recently contributed to the understanding of melanoma progression. Genetic instability and mutations of putative melanoma susceptibility genes are key factors involved in increased melanoma risk. The iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8de3c7d4b244bce4fb2e4da01cb81de
https://doi.org/10.1097/00001622-199403000-00012

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Outer root sheath (ORS) cells organize into epidermoid cyst-like spheroids when cultured inside Matrigel: a light-microscopic and immunohistological comparison between human ORS cells and interfollicular keratinocytes

Autor: Norbert E. Fusenig, F. Noser, A. Limat, Dirk Breitkreutz, Thomas Hunziker, Lasse R. Braathen, C. E. Klein

Publikováno v: Cell and Tissue Research. 275:169-176

In organotypic cultures, outer root sheath (ORS) cells of the human hair follicle develop into a stratified epithelium largely reminiscent of the epidermis; this apparently reflects their importance during wound healing. In the present study, ORS cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704275363850e044522922fff29ea75d
https://doi.org/10.1007/bf00305384

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Discrimination of parakeratinised odontogenic keratocysts from other odontogenic and non-odontogenic cyst types by expression of a 38kd cell-surface glycoprotein

Autor: P. A. Robinson, C. E. Klein, A. S. High

Publikováno v: Journal of Oral Pathology and Medicine. 22:363-367

We have identified strong expression of a 38-kD cell surface glycoprotein (gp38), a marker of basal cell carcinomas (BCCs), in basal and suprabasal epithelial cell membranes of parakeratinised odontogenic keratocysts. In contrast, orthokeratinised cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6ffcfd659b62b636feca7181092634
https://doi.org/10.1111/j.1600-0714.1993.tb01090.x

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Biochemical Characterization of Trop-2, a Cell Surface Molecule Expressed by Human Carcinomas: Formal Proof that the Monoclonal Antibodies T16 and MOv-16 Recognize Trop-2

Autor: M I Colnaghi, Silvia Miotti, Saverio Alberti, S Menard, Mara Fornaro, M Stella, C E Klein

Publikováno v: Scopus-Elsevier

Trop-2 is a cell surface structure recognized by the 162-46.2 mAb and expressed by most human carcinomas. Since the 162-46.2 mAb works poorly in immunoprecipitation, to characterize the structure of Trop-2 we searched for other mAbs directed against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83ded8f599add7bec9602669925c09a
https://doi.org/10.1089/hyb.1992.11.539

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Integrin alpha 2 beta 1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils

Autor: D Dressel, C E Klein, Lutz Weber, T Steinmayer, C Mauch, T. Krieg, B. Eckes, Richard B. Bankert

Publikováno v: The Journal of Cell Biology

The ability of cultured human fibroblasts to reorganize and contract three dimensional collagen I gels is regarded as an in vitro model for the reorganization of connective tissue during wound healing. We investigated whether adhesion receptors of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcad4f8158c42a09e0997c3dfda8261
https://doi.org/10.1083/jcb.115.5.1427

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