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Akademický článek

Examining the role of community resilience and social capital on mental health in public health emergency and disaster response: a scoping review

Autor: C. E. Hall, H. Wehling, J. Stansfield, J. South, S. K. Brooks, N. Greenberg, R. Amlôt, D. Weston

Publikováno v: BMC Public Health, Vol 23, Iss 1, Pp 1-13 (2023)

Abstract The ability of the public to remain psychologically resilient in the face of public health emergencies and disasters (such as the COVID-19 pandemic) is a key factor in the effectiveness of a national response to such events. Community resili

Externí odkaz: https://doaj.org/article/44b559a9efce4454b45de843a0d40634

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Akademický článek

Microglia coordinate cellular interactions during spinal cord repair in mice

Autor: Faith H. Brennan, Yang Li, Cankun Wang, Anjun Ma, Qi Guo, Yi Li, Nicole Pukos, Warren A. Campbell, Kristina G. Witcher, Zhen Guan, Kristina A. Kigerl, Jodie C. E. Hall, Jonathan P. Godbout, Andy J. Fischer, Dana M. McTigue, Zhigang He, Qin Ma, Phillip G. Popovich

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Here the authors show, using microglia-specific depletion techniques and single cell transcriptomics, that optimal repair after murine spinal cord injury (SCI) requires microglia.

Externí odkaz: https://doaj.org/article/c71897bb4488416ab0aceb965a3c158b

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Akademický článek

Spinal cord injury causes chronic bone marrow failure

Autor: Randall S. Carpenter, Jessica M. Marbourg, Faith H. Brennan, Katherine A. Mifflin, Jodie C. E. Hall, Roselyn R. Jiang, Xiaokui M. Mo, Malith Karunasiri, Matthew H. Burke, Adrienne M. Dorrance, Phillip G. Popovich

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration

Externí odkaz: https://doaj.org/article/0d1de6f876b2431485cb553f43443b20

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Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial Cells

Autor: Camila Marques Freria, Steve Lacroix, Xiaoyu Liu, Faith H. Brennan, Zhen Guan, Kristina A. Kigerl, Dániel Németh, David R Sweet, Ning Quan, Jodie C. E. Hall, Phillip G. Popovich

Publikováno v: J Neurosci

Microglia are dynamic immunosurveillance cells in the CNS. Whether microglia are protective or pathologic is context dependent; the outcome varies as a function of time relative to the stimulus, activation state of neighboring cells in the microenvir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8b795e38b3f7a000c7710ea8567b0a
https://doi.org/10.1523/jneurosci.0131-20.2020

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Spinal cord injury causes chronic bone marrow failure

Autor: Faith H. Brennan, Phillip G. Popovich, Jessica M. Marbourg, Katherine A. Mifflin, Adrienne M. Dorrance, Xiaokui M. Mo, Randall S. Carpenter, Matthew H. Burke, Roselyn R. Jiang, Jodie C. E. Hall, Malith Karunasiri

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications

Spinal cord injury (SCI) causes immune dysfunction, increasing the risk of infectious morbidity and mortality. Since bone marrow hematopoiesis is essential for proper immune function, we hypothesize that SCI disrupts bone marrow hematopoiesis. Indeed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695b8933c6963bee584db1b8eec7b679
https://doi.org/10.1038/s41467-020-17564-z

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Acute Budd–Chiari syndrome caused by inferior vena cava compression from a congenital diaphragmatic hernia

Autor: C E Hall, N Abbassi-Ghadi, K M Wcislo

Publikováno v: Ann R Coll Surg Engl

Acute Budd–Chiari syndrome is a rare condition characterised by obstruction of hepatic venous outflow. We describe the case of a 52-year-old man, with a congenital Morgagni diaphragmatic hernia, who presented with acute onset abdominal pain, shortn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925d80487fb2f971d306b3e457956539
https://europepmc.org/articles/PMC7538725/

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Human immune cells infiltrate the spinal cord and impair recovery after spinal cord injury in humanized mice

Autor: Phillip G. Popovich, Manoj K. Gottipati, Faith H. Brennan, Stefan Niewiesk, Randall S. Carpenter, Jodie C. E. Hall, Roselyn R. Jiang

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)

Humanized mice can be used to better understand how the human immune system responds to central nervous system (CNS) injury and inflammation. The optimal parameters for using humanized mice in preclinical CNS injury models need to be established for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739150a71ab03da4aab563fd8c383428
http://europepmc.org/articles/PMC6911055

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Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice

Autor: Phillip G. Popovich, Camila Marques Freria, Ping Wei, Zhen Guan, Jodie C. E. Hall, Dana M. McTigue

Publikováno v: The Journal of Neuroscience. 37:3568-3587

Impaired signaling via CX3CR1, the fractalkine receptor, promotes recovery after traumatic spinal contusion injury in mice, a benefit achieved in part by reducing macrophage-mediated injury at the lesion epicenter. Here, we tested the hypothesis that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba212bd29ec2bdb6ddbc380355aea710
https://doi.org/10.1523/jneurosci.2841-16.2017

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Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury

Autor: Tracey Baskerville, T. H. Richard Ip, Adina T. Michael-Titus, Moumin A. E. K. Mohamed, Amy L. Bowes, Fanuelle Getachew, John V. Priestley, Ping K. Yip, Zhuo-Hao Liu, Phillip G. Popovich, Anna D. Lindsay, Jodie C. E. Hall, Saif-Ur-Rehman Najeeb, Miguel Angel Burguillos

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Microglia are activated after spinal cord injury (SCI), but their phagocytic mechanisms and link to neuroprotection remain incompletely characterized. Docosahexaenoic acid (DHA) has been shown to have significant neuroprotective effects after hemisec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0733edd8ada34aa01120f917323e1fc4
http://hdl.handle.net/10261/214543

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miR-155 Deletion in Mice Overcomes Neuron-Intrinsic and Neuron-Extrinsic Barriers to Spinal Cord Repair

Autor: Zhen Guan, Andrew D. Gaudet, Xiaokui Mo, David R Sweet, Shweta Mandrekar-Colucci, Phillip G. Popovich, Philipp J Schmitt, Jodie C. E. Hall, Xinyang Xu, Mireia Guerau-de-Arellano

Publikováno v: Journal of Neuroscience. 36:8516-8532

Axon regeneration after spinal cord injury (SCI) fails due to neuron-intrinsic mechanisms and extracellular barriers including inflammation. microRNA (miR)-155–5p is a small, noncoding RNA that negatively regulates mRNA translation. In macrophages,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616cf7dcff1170723c36e3caf9a3de02
https://doi.org/10.1523/jneurosci.0735-16.2016

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