Zobrazeno 1 - 10
of 222
pro vyhledávání: '"C. Dugas"'
Autor:
Fen Huang, Yuda Zhu, Jennifer Hsiao‐Nakamoto, Xinyan Tang, Jason C. Dugas, Miriam Moscovitch‐Lopatin, Jonathan D. Glass, Robert H. Brown Jr, Shafeeq S. Ladha, David Lacomis, Jeffrey M. Harris, Kimberly Scearce‐Levie, Carole Ho, Robert Bowser, James D. Berry
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 7, Pp 1103-1116 (2020)
Abstract Objective To investigate neurodegenerative and inflammatory biomarkers in people with amyotrophic lateral sclerosis (PALS), evaluate their predictive value for ALS progression rates, and assess their utility as pharmacodynamic biomarkers for
Externí odkaz:
https://doaj.org/article/11d05d5c58d74cc2b606aa11605a30ba
Autor:
Annie Arguello, René Meisner, Elliot R. Thomsen, Hoang N. Nguyen, Ritesh Ravi, Jeffrey Simms, Iris Lo, Jessica Speckart, Julia Holtzman, Thomas M. Gill, Darren Chan, Yuhsiang Cheng, Chi-Lu Chiu, Jason C. Dugas, Meng Fang, Isabel A. Lopez, Hilda Solanoy, Buyankhishig Tsogtbaatar, Yuda Zhu, Akhil Bhalla, Kirk R. Henne, Anastasia G. Henry, Anthony Delucchi, Simona Costanzo, Jeffrey M. Harris, Dolores Diaz, Kimberly Scearce-Levie, Pascal E. Sanchez
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder caused by deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in cellular accumulation of glycosaminoglycans (GAGs) throughout the body. Treatment of MPS II remains a
Externí odkaz:
https://doaj.org/article/7257efca6a4647a28c441e395328432c
Autor:
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I. Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E. Pizzo, Rachel Prorok, Elliot Thomsen, Laura M. Bartos, Philipp Beumers, Anja Capell, Sonnet S. Davis, Lis de Weerd, Jason C. Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T. Kunte, Lea H. Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O. Torres, Hoang N. Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H. Suh, Robert G. Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y. Joy Yu Zuchero, Dolo Diaz, Mark S. Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J. Watts, Christian Haass, Joseph W. Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E. Sanchez, Kathryn M. Monroe
Publikováno v:
Nature neuroscience 26, 416-429 (2023). doi:10.1038/s41593-022-01240-0
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune receptor may be a useful therapeutic strategy. Here we describe a high-affinity human TREM2-activati
Autor:
Junhua Wang, Akhil Bhalla, Julie C. Ullman, Meng Fang, Ritesh Ravi, Annie Arguello, Elliot Thomsen, Buyankhishig Tsogtbaatar, Jing L. Guo, Lukas L. Skuja, Jason C. Dugas, Sonnet S. Davis, Suresh B. Poda, Kannan Gunasekaran, Simona Costanzo, Zachary K. Sweeney, Anastasia G. Henry, Jeffrey M. Harris, Kirk R. Henne, Giuseppe Astarita
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5449 (2020)
We recently developed a blood–brain barrier (BBB)-penetrating enzyme transport vehicle (ETV) fused to the lysosomal enzyme iduronate 2-sulfatase (ETV:IDS) and demonstrated its ability to reduce glycosaminoglycan (GAG) accumulation in the brains of
Externí odkaz:
https://doaj.org/article/8377888f3d43421b9fd6c2f9c0d4b08f
Autor:
M. Gebara, R. Brown, R. Blair, Z. Chen, C. Midkiff, S. Paredes, A. Das, C. Dugas, C. Thompson, K. Chandler, T. Bavaret, A. Birnbaum, R. Sato, V. Traina-Dorge, X. Qin, G. Piedimonte
Publikováno v:
B56. WHAT'S UP IN THE PNEUMONIA WORLD?.
Autor:
S.P. Desai, A. Agbodji, K. Craig, E. Pennie, R. Brown, I. Trinh, S. Rambaran, M. Gebara, S. Medearis, F. Carrion, C. Dugas, Y. Li, R. Satou, J. Robinson, E. Norton, S.H. Ley, G. Pridjian, S. Longo, G. Piedimonte
Publikováno v:
A26. CUTTING EDGE PEDIATRIC COVID-19 SCIENCE.
Autor:
S. Medearis, R. Brown, K. Pollard, A. Bosak, C. Dugas, A. Das, R. Sato, V. Traina-Dorge, M. Moore, G. Piedimonte
Publikováno v:
B56. WHAT'S UP IN THE PNEUMONIA WORLD?.
Autor:
S.P. Desai, E. Enwono, I. Trinh, A.E. Murrell, A. Agbodji, C. Dugas, R. Satou, S.N. Harris, G. Pridjian, K. Olson, S. Longo, S. Chandra, A. Smira, D. Elliot, J. Robinson, B.M. Gunn, G. Piedimonte, E.B. Norton
Publikováno v:
D105. MYSTERY SOLVED: CURIOUS CASES OF COVID-19.
Autor:
Takashi Miyamoto, Chaeyoung Kim, Johann Chow, Jason C Dugas, Jack DeGroot, Alex L Bagdasarian, Arun P Thottumkara, Martin Larhammar, Meredith EK Calvert, Brian M Fox, Joseph W Lewcock, Lesley A Kane
Sterile alpha and TIR motif containing 1 (SARM1) is a critical regulator of axon degeneration that acts through hydrolysis of NAD+ following injury. Recent work has defined the structure and catalytic activity of SARM1, yet the specific pathways cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e35b7fbb06d4ec2a209ab18294d6048
https://doi.org/10.1101/2022.04.27.489702
https://doi.org/10.1101/2022.04.27.489702
Autor:
Ari Shechter, Michael Airo, Jordan Valentin, Nicholas C. Dugas, Marwah Abdalla, Marie-Pierre St-Onge, Irene K. Louh
Publikováno v:
Journal of Clinical Medicine, Vol 8, Iss 8, p 1195 (2019)
A reciprocal relationship between obesity and obstructive sleep apnea (OSA) likely exists, wherein obesity contributes to OSA, and OSA-related sleep disturbances promote weight gain. It remains unclear whether continuous positive airway pressure (CPA
Externí odkaz:
https://doaj.org/article/349df278db9546399527a69b28465584