Deletion of the mouse RegIIIβ (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons

Autor: Luis Tebar, Sandrine M Géranton, Stephen P. Hunt, Gennadij Raivich, A. Sheasby, C De Felipe, Mark Turmaine, Abigail Fisher, Christian C. Ruff, Rosemary A. L. Bayne, Andrew D. M. Smith, S. Perez-Luz, C. Parsons-Perez

Publikováno v: Tebar, L A, Geranton, S M, Parsons-Perez, C, Fisher, A S, Bayne, R, Smith, A, Turmaine, M, Perez-Luz, S, Sheasby, A, De Felipe, C, Ruff, C, Raivich, G & Hunt, S P 2008, ' Deletion of the mouse RegIII beta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons ', Proceedings of the National Academy of Sciences, vol. 105, no. 32, pp. 11400-11405 . https://doi.org/10.1073/pnas.0711978105

A large number of cytokines and growth factors support the development and subsequent maintenance of postnatal motor neurons. RegIII beta, also known as Reg2 in rat and HIP/PAP1 in humans, is a member of a family of growth factors found in many areas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e5ecdbafcd34fcf6cc97aafe622831
https://doi.org/10.1073/pnas.0711978105

Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene

Autor: Teresa Olivar, Stephen P. Hunt, C. De Felipe, Fernando Cervero, Carolina Roza, Jennifer M.A. Laird

Publikováno v: Neuroscience. 98:345-352

Studies in mice lacking genes encoding for substance P or its receptor (NK1), or with NK1 antagonists, have shown that this system contributes to nociception, but the data are complex. Here, we have further examined the role of NK1 receptors in pain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef3ad7d1e58a8323f2e9819cd88b0c4
https://doi.org/10.1016/s0306-4522(00)00148-2

Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation

Autor: Kris Thielemans, Ines Carro-Muino, Bart N. Lambrecht, Guy Joos, C De Felipe, Els Everaert, M. De Veerman, Sp Hunt, Paul Germonpré, Romain Pauwels

Publikováno v: European Journal of Immunology. 29:3815-3825

Substance P (SP) is an immunoregulatory tachykinin which augments antigen- and mitogen-induced lymphocyte proliferation via signaling through the neurokinin-1 receptor (NK1-R). Non-neuronal cells of the immune system such as monocytes, T lymphocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2530d6cf355f4e0b968a011bdf6c5a78
https://doi.org/10.1002/(sici)1521-4141(199912)29:12<3815::aid-immu3815>3.0.co

Comparison of cardiorespiratory reflexes in NK1 receptor knockout, heterozygous and wild-type mice in vivo

Autor: SP Hunt, Julian F. R. Paton, James Butcher, C De Felipe, Andrew J.H. Smith

Publikováno v: Journal of the Autonomic Nervous System. 69:89-95

Neurokinin-1 receptors (NK1) are present within the nucleus of the solitary tract, a nucleus which plays a vital role in cardiovascular and respiratory homeostasis. We compared the efficacy of the baroreceptor and pulmonary chemoreflexes between NK1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22294f3743fbbf04fdac28df7fc61887
https://doi.org/10.1016/s0165-1838(98)00018-6

Differential patterns of immediate early gene expression following sensory stimulation or nerve damage

Autor: R. Jenkins, SP Hunt, Ross D O'Shea, C. De Felipe, S. Williams

Publikováno v: Restorative neurology and neuroscience. 5(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df6a810f24ef63df9de70e612b21f42
https://pubmed.ncbi.nlm.nih.gov/21551691