Zobrazeno 1 - 10
of 52
pro vyhledávání: '"C. David Williams"'
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0221841 (2020)
Cells are crowded and spatially heterogeneous, complicating the transport of organelles, proteins and other substrates. One aspect of this complex physical environment, the mobility of passively transported substrates, can be quantitatively character
Externí odkaz:
https://doaj.org/article/47e35dc6b89d4a89965494a0a4b41611
A mechanism for sarcomere breathing: volume change and advective flow within the myofilament lattice
Autor:
Sage A Malingen, Simon Sponberg, Julie A. Cass, C. David Williams, Thomas L. Daniel, Thomas C. Irving, Eric Lauga
Publikováno v:
Biophys J
During muscle contraction, myosin motors anchored to thick filaments bind to and slide actin thin filaments. These motors rely on energy derived from ATP, supplied, in part, by diffusion from the sarcoplasm to the interior of the lattice of actin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0671dfa2c29bc9cebf9ca5158ea7976a
https://pubmed.ncbi.nlm.nih.gov/34384761
https://pubmed.ncbi.nlm.nih.gov/34384761
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 11, p e1002770 (2012)
We most often consider muscle as a motor generating force in the direction of shortening, but less often consider its roles as a spring or a brake. Here we develop a fully three-dimensional spatially explicit model of muscle to isolate the locations
Externí odkaz:
https://doaj.org/article/35832767c2924f70826fe6fafb5b559b
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 12, p e1001018 (2010)
Nearly all mechanochemical models of the cross-bridge treat myosin as a simple linear spring arranged parallel to the contractile filaments. These single-spring models cannot account for the radial force that muscle generates (orthogonal to the long
Externí odkaz:
https://doaj.org/article/79995336b5fa44129b55e13d1ae12931
Autor:
Sean C. Kumer, C. David Williams, Bartholomew Kane, Hong-Min Ni, Benjamin L. Woolbright, Timothy M. Schmitt, Hartmut Jaeschke
Publikováno v:
Toxicon. 125:99-109
Microcystins are a group of toxins produced by freshwater cyanobacteria. Uptake of microcystin-leucine arginine (MC-LR) by organic anion transporting polypeptide 1B2 in hepatocytes results in inhibition of protein phosphatase 1A and 2A, and subsequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7accd8a810d67860c64a27a3f171fc55
https://doi.org/10.1016/j.toxicon.2016.11.254
https://doi.org/10.1016/j.toxicon.2016.11.254
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0221841 (2020)
PLoS ONE, Vol 15, Iss 5, p e0221841 (2020)
Cells are crowded and spatially heterogeneous, complicating the transport of organelles, proteins and other substrates. One aspect of this complex physical environment, the mobility of passively transported substrates, can be quantitatively character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ec91649edb834c4f7ba012b04bc732
https://pubmed.ncbi.nlm.nih.gov/32379846
https://pubmed.ncbi.nlm.nih.gov/32379846
Publikováno v:
Biophysical Journal
Biophysical journal, vol 117, iss 9
Biophysical journal, vol 117, iss 9
Cell shapes and connectivities evolve over time as the colony changes shape or embryos develop. Shapes of intercellular interfaces are closely coupled with the forces resulting from actomyosin interactions, membrane tension, or cell-cell adhesions. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2815cdc1daae8da958dac32cf02131
https://pubmed.ncbi.nlm.nih.gov/31648791
https://pubmed.ncbi.nlm.nih.gov/31648791
Publikováno v:
Integrative and comparative biology. 58(2)
In striated muscle, the giant protein titin spans the entire length of a half-sarcomere and extends from the backbone of the thick filament, reversibly attaches to the thin filaments, and anchors to the dense protein network of the z-disk capping the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e9736927388861544f1257fa40299f
https://pubmed.ncbi.nlm.nih.gov/29897447
https://pubmed.ncbi.nlm.nih.gov/29897447
Publikováno v:
Toxicology and Applied Pharmacology. 281:58-66
Acetaminophen (APAP) overdose causes severe hepatotoxicity in animals and humans. However, the mechanisms underlying the gender differences in susceptibility to APAP overdose in mice have not been clarified. In our study, APAP (300 mg/kg) caused seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151a6529314b080a6a35c202b6d3aa71
https://doi.org/10.1016/j.taap.2014.09.002
https://doi.org/10.1016/j.taap.2014.09.002
Autor:
Mengde Cao, Mitchell R. McGill, Anwar Farhood, C. David Williams, Stanislav I. Svetlov, Archie Svetlov, Hartmut Jaeschke, Steven C. Curry, Matthew R. Sharpe
Publikováno v:
Biomarkers. 19:222-230
Context: New biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate synthetase (ASS) is a promising candidate.Objective: Characterize ASS in APAP hepatotoxicity.Methods: ASS was measured in plasma from rodents and huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cbf230e8245fe36a6f16a852a6eaec
https://doi.org/10.3109/1354750x.2014.897757
https://doi.org/10.3109/1354750x.2014.897757