Zobrazeno 1 - 10
of 43
pro vyhledávání: '"C. David Pessoa-Mahana"'
Autor:
Marcos Lorca, Yudisladys Valdes, Hery Chung, Javier Romero-Parra, C. David Pessoa-Mahana, Jaime Mella
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2510 (2019)
Fatty Acid Amide Hydrolase (FAAH) is one of the main enzymes responsible for endocannabinoid metabolism. Inhibition of FAAH increases endogenous levels of fatty acid ethanolamides such as anandamide (AEA) and thus consitutes an indirect strategy that
Externí odkaz:
https://doaj.org/article/5850a739376e401ba14a650f32d93e2a
Autor:
Ramiro Araya-Maturana, Claudio Saitz Barría, Gerald Zapata-Torres, C. David Pessoa-Mahana, Gonzalo Recabarren-Gajardo, Jenny Fiedler Temer, Hernán Pessoa-Mahana
Publikováno v:
Molecules, Vol 17, Iss 2, Pp 1388-1407 (2012)
A series of novel benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and evaluated for their affinity towards 5-HT1A receptors. The influence of arylpiperazi
Externí odkaz:
https://doaj.org/article/a43ec701767f40089ad15f2a7b1bef8c
Autor:
Gonzalo Vera, Carlos F. Lagos, Sebastián Almendras, Dan Hebel, Francisco Flores, Gissella Valle-Corvalán, C. David Pessoa-Mahana, Jaime Mella-Raipán, Rodrigo Montecinos, Gonzalo Recabarren-Gajardo
Publikováno v:
Molecules, Vol 21, Iss 8, p 1070 (2016)
Based on a known pharmacophore model for 5-HT6 receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT6 receptor modulators. Eight of the compounds exhibited
Externí odkaz:
https://doaj.org/article/cf1f81bde6e74fedae6eef237b51af6e
Autor:
Hery Chung, Rodrigo Osorio, Martin Hodar-Salazar, Ramiro Araya-Maturana, Julio Rodríguez-Lavado, Claudio Saitz, Michael Mallea, Marcos Lorca, Patricio Iturriaga-Vásquez, Jaime Mella-Raipán, Pablo Jaque, C. David Pessoa-Mahana, Carlos Andrés Gallardo-Garrido, Victor Bustos, Miguel Reyes-Parada, Hernán Pessoa-Mahana
Publikováno v:
European journal of medicinal chemistry. 198
During the last decade, the one drug-one target strategy has resulted to be inefficient in facing diseases with complex ethiology like Alzheimer’s disease and many others. In this context, the multitarget paradigm has emerged as a promising strateg
Autor:
Javier Romero-Parra, Maria Jose Torres, C. David Pessoa-Mahana, Gonzalo Cabrera, Mario Faúndez, Angélica Fierro
Publikováno v:
European Journal of Pharmacology. 799:41-47
Leukotriene A 4 hydrolase is a soluble enzyme with epoxide hydrolase and aminopeptidase activities catalysing the conversion of leukotriene A 4 to leukotriene B 4 and the hydrolysis of the peptide proline-glycine-proline. Imbalances in leukotriene B
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0220025 (2019)
PLoS ONE, Vol 14, Iss 7, p e0220025 (2019)
Recent evidence has raised in discussion the possibility that cannabidiol can act as a negative allosteric modulator of the cannabinoid type 1 receptor. Here we have used computational methods to study the modulation exerted by cannabidiol on the eff
Autor:
Hery Chung, Yudisladys Valdes, Jaime Mella, C. David Pessoa-Mahana, Marcos Lorca, Javier Romero-Parra
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 10
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2510 (2019)
Volume 20
Issue 10
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2510 (2019)
Fatty Acid Amide Hydrolase (FAAH) is one of the main enzymes responsible for endocannabinoid metabolism. Inhibition of FAAH increases endogenous levels of fatty acid ethanolamides such as anandamide (AEA) and thus consitutes an indirect strategy that
Fatty Acid Amide Hydrolase (FAAH) is one of the enzymes responsible of endocannabinoids metabolism. The inhibition of FAAH is a useful and indirect strategy to raise endogenous cannabinoid concentrations, which would be useful for the treatment of va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18e5f32d709da239f0f5763349f40f9
Autor:
Patricio Iturriaga-Vásquez, Carlos F. Lagos, Jaime Mella-Raipán, Hernán Pessoa-Mahana, Christian Espinosa-Bustos, Ricardo A. Tapia, Ana María Zárate, Gonzalo Recabarren-Gajardo, Javier Romero-Parra, C. David Pessoa-Mahana
Publikováno v:
Archiv der Pharmazie. 348:81-88
A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand binding affinity assays were performed. Eight novel benzimidazoles
Autor:
Cesar Morales-Verdejo, Jaime Mella, Vincenzo Di Marzo, Hery Chung, Mario Faúndez, Carlos F. Lagos, C. David Pessoa-Mahana, Javier Romero-Parra, Marcos Lorca, Ricardo A. Tapia
Publikováno v:
European journal of pharmaceutical sciences 101 (2017): 1–10. doi:10.1016/j.ejps.2017.01.037
info:cnr-pdr/source/autori:Romero-Parra, Javier; Chung, Hery; Tapia, Ricardo A.; Faundez, Mario; Morales-Verdejo, Cesar; Lorca, Marcos; Lagos, Carlos F.; Di Marzo, Vincenzo; Pessoa-Mahana, C. David; Mella, Jaime/titolo:Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor/doi:10.1016%2Fj.ejps.2017.01.037/rivista:European journal of pharmaceutical sciences/anno:2017/pagina_da:1/pagina_a:10/intervallo_pagine:1–10/volume:101
info:cnr-pdr/source/autori:Romero-Parra, Javier; Chung, Hery; Tapia, Ricardo A.; Faundez, Mario; Morales-Verdejo, Cesar; Lorca, Marcos; Lagos, Carlos F.; Di Marzo, Vincenzo; Pessoa-Mahana, C. David; Mella, Jaime/titolo:Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor/doi:10.1016%2Fj.ejps.2017.01.037/rivista:European journal of pharmaceutical sciences/anno:2017/pagina_da:1/pagina_a:10/intervallo_pagine:1–10/volume:101
The preceding years have brought an exponential increase in our understanding of the endocannabinoid system (ECS), including the knowledge of CB1 and CB2 cannabinoid receptors, endocannabinoids, and the enzymes that synthesize and degrade endocannabi