Výsledky vyhledávání - "C. David Pendleton"

Akademický článek

Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE.

Autor: Yi-Hsiang Huang, Masaki Terabe, C David Pendleton, Deborah Stewart Khursigara, Tapan K Bera, Ira Pastan, Jay A Berzofsky

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e64365 (2013)

Identification of CD8(+) T cell epitopes that can induce T cells to kill tumor cells is a fundamental step for development of a peptide cancer vaccine. POTE protein is a newly identified cancer antigen that was found to be expressed in a wide variety

Externí odkaz: https://doaj.org/article/e287a5b843b0419f8d53a1ca0ea0bf16

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Protective immunity provided by HLA-A2 epitopes for fusion and hemagglutinin proteins of measles virus

Autor: Brian Stegman, Martin O. Ota, C. David Pendleton, Diane E. Griffin, Donald S. Burke, Chien Hsiung Pan, Sang Kon Oh, Jay A. Berzofsky

Publikováno v: Virology. 352:390-399

Natural infection and vaccination with a live-attenuated measles virus (MV) induce CD8+ T-cell-mediated immune responses that may play a central role in controlling MV infection. In this study, we show that newly identified human HLA-A2 epitopes from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bcb55fc0715388d1bcc1e781fe1304
https://doi.org/10.1016/j.virol.2006.04.040

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Epitope Enhancement of a CD4 HIV Epitope toward the Development of the Next Generation HIV Vaccine

Autor: Sujatha Iyengar, Jay A. Berzofsky, Thomas Elaine K, Takahiro Okazaki, C. David Pendleton, David C. Schwartz, Pablo Sarobe, Clayton Harro

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Virus-specific CD4+ T cell help and CD8+ cytotoxic T cell responses are critical for maintenance of effective immunity in chronic viral infections. The importance of CD4+ T cells has been documented in HIV infection. To investigate whether a stronger

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5315cb4f117d0b307228732114c380dd
https://doi.org/10.4049/jimmunol.176.6.3753

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Identification and Epitope Enhancement of a PAX-FKHR Fusion Protein Breakpoint Epitope in Alveolar Rhabdomyosarcoma Cells Created by a Tumorigenic Chromosomal Translocation Inducing CTL Capable of Lysing Human Tumors

Autor: Lee J. Helman, C. David Pendleton, Jay A. Berzofsky, Crystal L. Mackall, Leon T. van den Broeke

Publikováno v: Cancer Research. 66:1818-1823

Fusion proteins created by chromosomal translocations in tumors can create neoantigenic determinants at the breakpoint, which are unique to the tumor cells but shared by the vast majority of tumors of that histologic type. If the fusion protein is re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c602d2cba236e87ef17ef920c63d55
https://doi.org/10.1158/0008-5472.can-05-2549

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Immunization With Mutantp53- andK-ras–Derived Peptides in Cancer Patients: Immune Response and Clinical Outcome

Autor: Michael Stipanov, Jay A. Berzofsky, M. Charles Smith, I. Frank Ciernik, Denise Kavanaugh, Charley Carter, Elizabeth J. Read, David Contois, Morris I. Kelsey, Sorena Nadaf, Burkhardt Seifert, Lois E. Top, John D. Minna, C. David Pendleton, Bruce E. Johnson, Michael J. Kelley, David P. Carbone, Jay Greenblatt, V. Ellen Maher

Publikováno v: Journal of Clinical Oncology. 23:5099-5107

PurposeTo determine the ability to induce tumor-specific immunity with individual mutant K-ras–or p53-derived peptides and to monitor clinical outcome.Patients and MethodsPatients in varying stages of disease underwent genetic analysis for mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d8c32f2572e9746b8ddbdd0c2a8991
https://doi.org/10.1200/jco.2005.03.158

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The Importance of Pairwise Interactions Between Peptide Residues in the Delineation of TCR Specificity

Autor: Graham R. Leggatt, Anne Hosmalin, C. David Pendleton, Anita Kumar, Stephen Hoffman, Jay A. Berzofsky

Publikováno v: The Journal of Immunology. 161:4728-4735

A minimal, nonamer epitope (TEMEKEGKI) from the reverse transcriptase protein of HIV-1, restricted by H-2Kk, was identified and the function of individual residues determined. Besides classical anchor residues at positions 2 and 9, methionine at posi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4c981db0e443eb7eacd0c57ff7f8931
https://doi.org/10.4049/jimmunol.161.9.4728

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Induction of a Mucosal Cytotoxic T-Lymphocyte Response by Intrarectal Immunization with a Replication-Deficient Recombinant Vaccinia Virus Expressing Human Immunodeficiency Virus 89.6 Envelope Protein

Autor: Warren Strober, Linda S. Wyatt, Patricia L. Earl, Brian L. Kelsall, Jay A. Berzofsky, Jeffrey D. Ahlers, Bernard Moss, C. David Pendleton, Igor M. Belyakov

Publikováno v: Journal of Virology. 72:8264-8272

To improve the safety of recombinant vaccinia virus vaccines, modified vaccinia virus Ankara (MVA) has been employed, because it has a replication defect in most mammalian cells. Here we apply MVA to human immunodeficiency virus type 1 (HIV-1) vaccin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f48316f799afe2d3ab369a68241277
https://doi.org/10.1128/jvi.72.10.8264-8272.1998

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Molecular analysis of presentation by HLA-A2.1 of a promiscuously binding V3 loop peptide from the HIV-1 envelope protein to human cytotoxic T lymphocytes

Autor: Jay A. Berzofsky, Martha A. Alexander-Miller, C. David Pendleton, Taku Tsukui, John E. Coligan, Kenneth C. Parker

Publikováno v: International Immunology. 8:641-649

P18IIIB is a highly immunogenic peptide from the V3 loop of the HIV-1 gp160 envelope protein that is presented promiscuously by multiple class I MHC molecules. Understanding the molecular basis for promiscuous presentation may have many practical app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c48bc25ede1895824543d05e056c33b3
https://doi.org/10.1093/intimm/8.5.641

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Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells

Autor: Claude Kasten-Sportes, John Phillips, Jay A. Berzofsky, W. Marston Linehan, Yoram Reiter, Tapan K. Bera, Malka Epel, Ira Pastan, Sangkon Oh, Anu Bhattacharyya, C. David Pendleton, Masaki Terabe

Publikováno v: Cancer research. 64(7)

Vaccine therapy for prostate and breast cancer may have potential for treating these major causes of death in males and females, respectively. Critical to the development of tumor-specific vaccines is finding and characterizing novel antigens to be r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2aaf689993374924390456d28446e6
https://pubmed.ncbi.nlm.nih.gov/15059918

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Epitope-enhanced conserved HIV-1 peptide protects HLA-A2-transgenic mice against virus expressing HIV-1 antigen

Autor: Jay A. Berzofsky, Takahiro Okazaki, François A. Lemonnier, C. David Pendleton

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 171(5)

HIV epitopes may have developed to be poor immunogens. As a counterapproach HIV vaccine strategy, we used epitope enhancement of a conserved HIV reverse transcriptase (RT) epitope for induction of antiviral protection in HLA-A2-transgenic mice mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c656748583d8d1ea07cfcd4c2d3e7739
https://pubmed.ncbi.nlm.nih.gov/12928405

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