Zobrazeno 1 - 10
of 173
pro vyhledávání: '"C. David Pauza"'
Autor:
Nidal Muvarak, Haishan Li, Tyler Lahusen, Jeffrey A. Galvin, Princy N. Kumar, C. David Pauza, José Bordon
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
The cell and gene therapy product AGT103-T was designed to restore the Gag-specific CD4+ T cell response in persons with chronic HIV disease who are receiving antiretroviral therapy. This autologous, genetically engineered cell product is under inves
Externí odkaz:
https://doaj.org/article/47927a7ea0e545aeb40b3354b73168e0
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human Vγ9Vδ2 T cells are attractive candidates for cancer immunotherapy due to their potent capacity for tumor recognition and cytolysis of many tumor cell types. However, efforts to deploy clinical strategies for Vγ9Vδ2 T cell cancer therapy are
Externí odkaz:
https://doaj.org/article/d7b465357b424c4b959e814eaca22518
Autor:
Haishan Li, Tyler Lahusen, Lingzhi Xiao, Nidal Muvarak, Jana Blazkova, Tae-Wook Chun, C. David Pauza
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 1048-1060 (2020)
Activation, infection, and eventual depletion of human immunodeficiency virus (HIV)-specific cluster of differentiation 4 (CD4) T cells are the crucial pathogenetic events in acquired immunodeficiency syndrome (AIDS). We developed a cell and gene the
Externí odkaz:
https://doaj.org/article/537a7b1f723a4249a33ac8a83b49f5da
Autor:
Xiaoyang Liu, Senthilkumar Palaniyandi, Iowis Zhu, Jin Tang, Weizhong Li, Xiaoling Wu, Susan Park Ochsner, C. David Pauza, Jeffrey I. Cohen, Xiaoping Zhu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Human cytomegalovirus (HCMV) can persist for the life of a host in the face of robust immune responses owing to a wide range of immune evasion strategies. Here Liu and colleagues show that HCMV evades the IgG-mediated response by the endoplasmic reti
Externí odkaz:
https://doaj.org/article/6e85368b58fb47d9aed9931f8276b0ca
Publikováno v:
COVID. 2:1057-1076
A complete response to the challenge of COVID-19 requires diagnosis, prevention, and treatment strategies. Until recently, the treatment arm has included largely ineffective, often unproven medications with minimal impact on disease outcomes. The ear
Autor:
C. David Pauza, Mei-Ling Liou, Tyler Lahusen, Lingzhi Xiao, Rena G. Lapidus, Cristiana Cairo, Haishan Li
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Human gamma delta T cells have extraordinary properties including the capacity for tumor cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and is activated by intermediates of isoprenoid biosynthesis or aminobis
Externí odkaz:
https://doaj.org/article/f3ee17bfedcb41ad9fcec3309a001cb9
Autor:
Shashwatee Bagchi, Shana AB Burrowes, Lori E Fantry, Mian B Hossain, Gemechis H Tollera, Shyamasundaran Kottilil, C David Pauza, Michael Miller, Mona Baumgarten, Robert R Redfield
Publikováno v:
SAGE Open Medicine, Vol 5 (2017)
Objective: To determine factors associated with increased risk of developing cardiovascular disease in a high-risk patient population. Design: Cross-sectional analysis of a retrospective cohort study. Methods: One-hundred patients at an inner city HI
Externí odkaz:
https://doaj.org/article/6eda0d59e9d94cde9f434052de643ad6
Autor:
Tae-Wook Chun, Lingzhi Xiao, C. David Pauza, Jana Blazkova, Tyler Lahusen, Haishan Li, Nidal Muvarak
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 1048-1060 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Activation, infection, and eventual depletion of human immunodeficiency virus (HIV)-specific cluster of differentiation 4 (CD4) T cells are the crucial pathogenetic events in acquired immunodeficiency syndrome (AIDS). We developed a cell and gene the
Autor:
Juan D Rodas, Cristiana Cairo, Mahmoud Djavani, Juan Carlos Zapata, Tracy Ruckwardt, Joseph Bryant, C David Pauza, Igor S Lukashevich, Maria S Salvato
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 104, Iss 4, Pp 583-591 (2009)
Rhesus macaques infected with the WE strain of lymphocytic choriomeningitis virus (LCMV-WE) serve as a model for human infection with Lassa fever virus. To identify the earliest events of acute infection, rhesus macaques were monitored immediately af
Externí odkaz:
https://doaj.org/article/6433424f91b0408680d183ae5dc43c8e
Autor:
Bhawna Poonia, C David Pauza
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88884 (2014)
Prolonged antiretroviral therapy (ART) with effective HIV suppression and reconstitution of CD4 T cells, fails to restore CD8 T cell lytic effector function that is needed to eradicate the viral reservoir. Better understanding of the phenotype and fu
Externí odkaz:
https://doaj.org/article/e12685332e48491aa7b14a0412f5b537