Zobrazeno 1 - 10
of 20
pro vyhledávání: '"C. D. Pessoa-Mahana"'
Autor:
Hery Chung, Claudia Ojeda-Gómez, Jazmín Alarcón-Espósito, Julio Rodríguez-Lavado, Claudio Saitz, Jaime Mella-Raipán, Ramiro Araya-Maturana, Patricio Iturriaga-Vásquez, David Cabezas, C. D. Pessoa-Mahana, Hernán Pessoa-Mahana, Gabriel Quiroz, Miguel Reyes-Parada, Christopher Cerda-Cavieres
Publikováno v:
Molecules
Volume 25
Issue 20
Molecules, Vol 25, Iss 4614, p 4614 (2020)
Volume 25
Issue 20
Molecules, Vol 25, Iss 4614, p 4614 (2020)
A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a&ndash
o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)-N-(2-morfolin-4-yl-
o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)-N-(2-morfolin-4-yl-
Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism
Autor:
J. Cortés-Rios, Hernán Pessoa-Mahana, David Vásquez, C. D. Pessoa-Mahana, Ramiro Araya-Maturana, Mario Faúndez, C. Gallardo-Garrido, Young Hwa Cho
Publikováno v:
Toxicology and Applied Pharmacology. 401:115104
Nitrofurans (5-nitro-2-hydrazonylfuran as pharmacophore) are a group of widely used antimicrobial drugs but also associated to a variety of side effects. The molecular mechanisms that underlie the cytotoxic effects of nitrofuran drugs are not yet cle
Autor:
Jaime Mella, Mauricio Cuellar, Marco Mellado, Luisa Montoya, C. D. Pessoa-Mahana, Cesar Morales-Verdejo, Carlos F. Lagos, Gastón Apablaza, Jorge Soto-Delgado, Hery Chung
Publikováno v:
Molecules, Vol 22, Iss 3, p 404 (2017)
Molecules; Volume 22; Issue 3; Pages: 404
Molecules; Volume 22; Issue 3; Pages: 404
Indexación: Web of Science; Scopus. The beta(3) adrenergic receptor is raising as an important drug target for the treatment of pathologies such as diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selectiv
Autor:
Claudio Méndez-Rojas, C. D. Pessoa-Mahana, Claudia Ojeda-Gómez, Patricio Iturriaga-Vásquez, Gonzalo Recabarren-Gajardo, Hernán Pessoa-Mahana
Publikováno v:
Archiv der Pharmazie. 347:174-184
A series of functionalized indolylalkylarenes 3-16(a and b) were synthesized and their affinities for the serotonin transporter were investigated in vitro. Compounds 3-12(a and b) were obtained by nucleophilic substitution of 3-(1H-indol-3-yl)propyl-
Autor:
Francisco X. Flores, Sebastián Almendras, Jaime Mella-Raipán, Gonzalo Recabarren-Gajardo, Gissella Valle-Corvalán, Gonzalo Vera, Carlos F. Lagos, Rodrigo Montecinos, C. D. Pessoa-Mahana, Dan Hebel
Publikováno v:
Molecules; Volume 21; Issue 8; Pages: 1070
Molecules, Vol 21, Iss 8, p 1070 (2016)
Molecules, Vol 21, Iss 8, p 1070 (2016)
Based on a known pharmacophore model for 5-HT6 receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT6 receptor modulators. Eight of the compounds exhibited
Autor:
Ramiro Araya-Maturana, Catalina Ugarte Núñez, Miguel Reyes-Parada, Hernán Pessoa-Mahana, Patricio Iturriaga-Vásquez, Jaime Mella-Raipán, Cristian Celis-Barros, C. D. Pessoa-Mahana, Claudio Saitz Barría, Gerald Zapata-Torres
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 60:632-638
A series of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives (12a-h) was synthesized and evaluated for binding affinity at the human 5-hydroxytryptamine(1A) receptor (5-HT(1A)R) compounds (12b) and (12h) showed the highest 5-HT(1A) receptor
Synthesis, characterization, and electrochemical studies of new 5- and 6-nitro N -acyl-1H -indazoles
Autor:
C. D. Pessoa-Mahana, Christian Espinosa-Bustos, Gonzalo Recabarren-Gajardo, M. A. del Valle, Manuel Gacitúa, Jaime Mella-Raipán, J. Romero, Ricardo A. Tapia, I. Murueva
Publikováno v:
Journal of Physical Organic Chemistry. 24:1179-1187
Two series of new N-1 acylindazoles containing 5- or 6-nitro groups were synthesized with moderate to good yields and characterized by IR and NMR spectroscopy. Cyclic voltammetry in aprotic media was utilized for the electrochemical characterization
Autor:
Max Romero, Benjamín Alberto Rojano, Jaime Mella-Raipán, Eduardo Lissi, Camilo López-Alarcón, C. D. Pessoa-Mahana
Publikováno v:
Molecules; Volume 15; Issue 9; Pages: 6152-6167
Molecules, Vol 15, Iss 9, Pp 6152-6167 (2010)
MOLECULES
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Molecules
Molecules, Vol 15, Iss 9, Pp 6152-6167 (2010)
MOLECULES
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Molecules
The protective effect of different antioxidants and complex mixtures on the consumption of pyrogallol red (PGR) induced by peroxyl radicals was studied in the absence and presence of Triton X-100 micelles. The presence of micelles decreased significa
Publikováno v:
Pharmaceutical Development and Technology. 13:127-133
The molecules 2-pyridin-3-yl-1H-benzimidazole and 2-pyridin-3-yl-1-(3,4,5-trimethoxybenzoyl)-1H-benzimidazole are compounds that have been synthesized with the aim of finding new inhibitors of the reverse transcriptase enzyme, which is key in the pro
Autor:
Hernán Pessoa-Mahana, B. Claudio Saitz, R. Rodrigo Acevedo, C. D. Pessoa-Mahana, Ramiro Araya-Maturana
Publikováno v:
Synthetic Communications. 37:1227-1235
A novel series of 2‐benzothienyl carbonyl arylpiperazines (6a–f) was synthesized as potential HIV nonnucleoside reverse transcriptase inhibitors (NNRTIs). Preparation of the derivatives was performed by reacting benzo[b]thiophene carbonyl chlorid