Zobrazeno 1 - 10 of 70 pro vyhledávání: '"C. D. Perchonock"'
1
Metabolism of the leukotriene receptor antagonist 5-(2-(8-phenyloctyl)phenyl)-4,6-dithianonanedioic acid (SKF 102922) in the guinea pig. Rearrangement of the acyl glucuronide
Autor: J F, Newton, K M, Straub, R H, Dewey, C D, Perchonock, M E, McCarthy, J G, Gleason, R K, Lynn
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 20(4)
A primary route of inactivation of leukotrienes and their receptor antagonists (LTRA) is metabolism by omega oxidation. SKF 102922 [5-(2-(8-phenyloctyl)phenyl)-4,6-dithianonanedioic acid] is a LTRA that was designed to be resistant to omega oxidation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb871c7d2e5913da97e6877f87314aba
https://pubmed.ncbi.nlm.nih.gov/1356721
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3
In vitro microsomal metabolism of the leukotriene receptor antagonist, 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid (SKF 102,081)
Autor: J F, Newton, K M, Straub, R H, Dewey, C D, Perchonock, T B, Leonard, M E, McCarthy, J G, Gleason, R D, Eckardt
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 15(2)
In vivo experiments indicate that the major route of metabolism of SKF 102,081 [5-(2-dodecylphenyl)-4,6-dithianonanedioic acid] is via omega-oxidation and subsequent beta-oxidation. Therefore, in vitro experiments were designed to characterize the in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbed507e41c51ba4b47924d0d74e02a6
https://pubmed.ncbi.nlm.nih.gov/2882972
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6
In vivo metabolism of the leukotriene receptor antagonist, 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid (SKF 102,081) in the guinea pig
Autor: J F, Newton, K M, Straub, G Y, Kuo, C D, Perchonock, M E, McCarthy, J G, Gleason, R K, Lynn
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 15(2)
Both leukotrienes and their receptor antagonists possess substantial pharmacologic activity in in vitro systems, but their duration of action in vivo is extremely short. The exact mechanism of rapid inactivation of these lipids is unknown, but is lik
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::809e8f78c6ffe99bcb83a7f9c7e697e6
https://pubmed.ncbi.nlm.nih.gov/2882973
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10
Gastric antisecretory 9H-xanthen-9-amines
Autor: P E, Bender, C D, Perchonock, W G, Groves, R C, Smith, O D, Stringer, R, Sneed, J H, Schlosser, L S, Hostelley, B Y, Hwang, R Z, Eby, G, Konicki, P G, Lavanchy, J W, Wilson, B, Loev
Publikováno v: Journal of medicinal chemistry. 26(9)
A series of 9H-xanthen-9-amines possessing a wide variety of nitrogen substituents at C-9 was prepared for evaluation of gastric antisecretory activity. These substituents included the acetamidine, imidate, pyrimidine, thiazoline, quinuclidine, 2-hyd
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e56db7ece79742a2f3c6084d428abad
https://pubmed.ncbi.nlm.nih.gov/6887196
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