Zobrazeno 1 - 10
of 16
pro vyhledávání: '"C. D. Manning"'
Publikováno v:
Experimental Brain Research. 226:33-43
Rotation of an upper limb joint produces excitatory stretch reflex peaks M1 and M2 in the stretched muscles and simultaneous decrease in electromyographic (EMG) activity in the shortened muscles. The objective of this study was to examine whether the
Publikováno v:
Experimental Brain Research. 221:155-166
The stretch of upper limb muscles results in two electromyographic (EMG) peaks, M1 and M2. The amplitude of M2 peak can generally be modified by giving prior instruction to the subject on how to react to the applied perturbation. The unresolved quest
Publikováno v:
Experimental Brain Research. 204:139-144
During prolonged contractions, few studies have reported rotation among low threshold motoneurons. The question arises whether a motoneuron stops firing due to an increase in firing threshold or whether it is due to regional switching of activity amo
Autor:
M Grous, M S Barnette, W. J. Price, W. E. Thompson, M. Fudge, F. C. Barone, A. F. Joslyn, H. S. Ormsbee, C. D. Manning
Publikováno v:
Neurogastroenterology & Motility. 2:65-72
Neuronal stimulation of most isolated precontracted gastrointestinal smooth muscle results in relaxation. This study examined the changes in cyclic nucleotide content associated with neuronally induced relaxation in sphincteric and nonsphincteric smo
Autor:
Azli Yahya, C D Manning
Publikováno v:
Journal of Physics D: Applied Physics. 37:1467-1471
This paper describes the use of dimensional analysis in investigating the effects of the electrical and the physical parameters on the material removal rate of a diesinking electro-discharge machine. A brief explanation of the material removal proces
Autor:
C D, Manning, M, Burman, S B, Christensen, L B, Cieslinski, D M, Essayan, M, Grous, T J, Torphy, M S, Barnette
Publikováno v:
British journal of pharmacology. 128(7)
1. Of the four major phosphodiesterase 4 (PDE4) subtypes, PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells, including monocytes and T lymphocytes. We explored the functional role of these subtypes using ten subtype-selective PD
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(2)
Human peripheral blood monocytes were treated for 4 h with a combination of the beta-agonist salbutamol (3 microM) and the low-Km cAMP-specific phosphodiesterase (PDE4) inhibitor rolipram (30 microM) to produce a prolonged elevation of cAMP and conse
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 273(2)
Elevation of cyclic AMP (cAMP) content inhibits eosinophil function. Because phosphodiesterase IV (PDE IV) appears to be the major PDE isozyme present in eosinophils, inhibitors of this isozyme should suppress eosinophil activation. Previous studies
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 264(2)
Cyclic nucleotides mediate relaxation of gastrointestinal smooth muscle. The intracellular concentration of these second messengers is determined by a balance between their synthesis and metabolism. Because cyclic nucleotide phosphodiesterase enzymes
Autor:
M S, Barnette, M, Grous, C D, Manning, W J, Price, A H, Nelson, W E, Bondinell, F C, Barone, H S, Ormsbee
Publikováno v:
Receptor. 2(3)
Addition of 5-HT or SKF 103829 (2,3,4,5 tetrahydro-8[methyl-sulfonyl]-1 H-3-benzazepin-7-ol hydrobromide) contracts isolated strips of canine lower esophageal sphincter (LES) circular smooth muscle. 5-HT acts directly on the smooth muscle, since pret