Rectal absorption enhancement of peptide drugs

Autor: E. J. Van Hoogdalem, Douwe D. Breimer, J.C. Verhoef, C D Heijligers-Feijen, A. G. De Boer

Publikováno v: Journal of Controlled Release. 13:241-246

There are various reasons for rectal drug administration. Two of the most obvious ones are situations when patients are vomiting or suffering from nausea, while it has also been shown that it is possible to avoid at least partially hepatic first-pass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::891b0b11ca931034c43d1cc8e260fe05
https://doi.org/10.1016/0168-3659(90)90014-k

Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures

Autor: J W, Mandema, C D, Heijligers-Feijen, E, Tukker, A G, De Boer, M, Danhof

Publikováno v: The Journal of pharmacology and experimental therapeutics. 261(1)

The plasma to effect site equilibration kinetics and the steady-state plasma concentration-EEG effect relationship of baclofen were characterized after separate administration of racemic baclofen and its two enantiomers. Male Wistar-derived rats rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6163a36b86f8cd5cf6843c847bdd9b6a
https://pubmed.ncbi.nlm.nih.gov/1560387

Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats

Autor: E J, van Hoogdalem, C D, Heijligers-Feijen, J C, Verhoef, A G, de Boer, D D, Breimer

Publikováno v: Pharmaceutical research. 7(2)

The bile salt derivative sodium tauro-24,25-dihydrofusidate (STDHF) has been reported to promote nasal absorption of insulin. In the present study the effect of STDHF on rectal insulin absorption was investigated in rats. At concentrations of 1 and 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1e4b27885f61afc71bf78f9f25b8448
https://pubmed.ncbi.nlm.nih.gov/2106676

Abstracts of Dutch doctoral theses

Autor: G. J. Navis, G. J. Sterk, J. W. van Nispen, M. Hichens, A. Sauter, H. Lingeman, C. M. B. van den Beld, U. R. Tjaden, J. van der Greef, D. M. Desiderio, D. C. Cubbins, C. McMartin, R. L. Webb, L. P. Wennogle, H. E. Wysowskyi, M. B. Zimmerman, V. H. L. Lee, J. Sandow, H. Seidel, R. Schmiedel, Bradley T. Keller, Kevin R. Smith, Ronald T. Borchardt, W. A. Banks, A. J. Kastin, D. de Wied, P. P. DeLuca, J. R. Robinson, S. Lundin, H. Vilhardt, M. Saffran, G. S. Kumar, D. G. Neckers, F. Williams, J. B. Field, R. H. Jones, L. Panepinto, A. S. Harris, Alan C. Moses, S. Muranishi, H. E. Boddé, M. Ponec, J. Verhoef, Gary G. Liversidge, G. J. Boer, J. Kruisbrink, H. de Nijs, T. R. M. Bouwman, M. J. D. Eenink, Harish M. Patel, H. Bundgaard, J. D. Larsen, M. N. Nielsen, A. Buur, U. R. Tjadeh, M. Lemaire, H. Andres, P. Marbach, L. Widlund, O. Guilbaud, P. Wilton, J. B. M. M. van Bree, K. L. Audus, Johanna Deinum, Karin Norén, Morgan Sohtell, B. R. Weström, H. G. Folkesson, B. W. Karlsson, C. Damge, C. Michel, M. Aprahamian, P. Couvreur, F. Puisieux, E. Touitou, F. Alhaique, P. Fisher, A. Memoli, F. M. Riccieri, E. Santucci, W. A. J. J. Hermens, S. G. Romei jn, F. W. H. H. Merkus, C. Schneider, T. W. Smith, K. -D. Bremecker, K. -D. Hungerer, Y. Tabata, Y. Ikada, K. Uno, S. Muramatsu, J. W. Bruning, F. H. J. Claas, M. J. Kardol, J. M. van Ree, C. J. J. Rust, W. Verduyn, V. M. Wiegant, G. Wolterink, E. J. van Hoogdalem, C. D. Heijligers-Feijen, A. G. de Boer, D. D. Breimer, C. B. Lambalk, H. van Kessel, J. de Koning, J. A. M. J. van Dieten, G. P. van Rees, J. Schoemaker, J. -Ph. Devissaguet, K. Orieu, F. Dray, E. Ezan, J. Ph. Devissaguet, K. Drieu, P. Dray, E. Ezah, D. J. Barnfield, Y. K. Barker, S. Knott, G. S. Miles, A. Warrander, H. K. Adam, Y. Barker, F. G. Hutchinson, R. A. V. Milsted, R. H. Moore, A. J. Swaisland, Y. Barke, E. T. Porter, B. Holmes, M. Barnard, J. H. Beijnen, S. C. H. Lubbers, O. A. G. J. van der Houwen, M. W. Lobbezoo, W. J. M. Underberg, Th. Cachet, E. Roets, J. Hoogmartens, H. Vanderhaeghe, H. de Bree, D. J. K. van der Stel, O. A. M. Brockhoff, M. P. van Berkel, K. Sierat, G. de Groot, B. C. A. Tepas, O. E. de Noord, J. Hempenius, P. M. J. Coenegracht, J. H. G. Jonkman, D. A. Doornbos, J. A. De Schutter, P. De Moerloose, L. P. C. Delbressine, F. M. Kaspersen, A. Blokland, A. L. L. Duchateau, T. A. Verstappen, P. J. H. Hendricks, F Elferink, O R Leeuwenkamp, H M Pinedo, W J F vd Vijgh, K. Ensing, D. A. Bloemhof, W. G. In 't Hout, R. A. de Zeeuw, Karla G. Feitsma, Ben F. H. Drenth, Rokus A. de Zeeuw, T. K. Gerding, B. F. H. Drenth, A. S. Horn, C. P. Groen, J. Tipker, J. K. van den Bergh-Swart, F. J. Spruit, J. H. M. van den Berg, E. H. Groot Bramel, O. Bekers, M. Otagiri, P. S. L. Janssen, J. W. v. Nispen, P. A. T. A. Melgers, M. J. M. v. Zeeland, R. L. A. E. Hamelinck, B. C. Goverde, G. W. M. v. Aalst, P. R. Kootstra, H. H. van den Broek, E. A. Hogendoorn, C. E. Goewie, P. J. M. Kwakman, U. A. Th. Brinkman, R. W. Frei, G. J. de Jong, N. G. F. M. Lammers, N. Lammers, H. M. Ruijten, J. de Jong, P. A. Maessen, K. B. Mross, H. M. Plnedo, W. J. F. van der Vljgh, Naeem Hasan Khan, S. V. Rose, L. G. D. Lammerts van Bueren, P. H. van Amsterdam, H. van Beek, A. J. Baars, L. A. van Ginkel, H. M. Steinbuch, H. J. van Rossum, H. van Blitterswijk, P. W. Zoontjes, E. v. d. Heeft, A. J. P. M. de Jong, R. W. Stephany, R. van Gijn, J. J. M. de Clippeleir, S. L. Verweij, A. C. A. Paalman, M. A. J. van Opstal, P. Krabbenborg, J. J. M. Holthuis, W. P. van Bennekom, A. Bult, F. A. M. Redegeld, E. Houdkamp, C. van de Water, N. Haagsma, D. E. M. M. Vendrig, A. Mekking, J. Teeuwsen

Publikováno v: Pharmaceutisch Weekblad. 10:26-29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8094f1e968d396217477c48350ef3246
https://doi.org/10.1007/bf01966432

Rectal absorption enhancement of cefoxitin and desglycinamide arginine vasopressin by sodium tauro-24,25-dihydrofusidate in conscious rats

Autor: E J, van Hoogdalem, C D, Heijligers-Feijen, R A, Mathôt, A T, Wackwitz, J B, van Bree, J C, Verhoef, A G, de Boer, D D, Breimer

Publikováno v: The Journal of pharmacology and experimental therapeutics. 251(2)

The effects of sodium tauro-24,25-dihydrofusidate (STDHF), an enhancer of nasal insulin absorption, on the rectal absorption of cefoxitin and desglycinamide arginine vasopressin (DGAVP) were evaluated in the rat. Cefoxitin and DGAVP proved to be poor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b4c8c894beb58fff6d1b2ba3f056510
https://pubmed.ncbi.nlm.nih.gov/2810123