Výsledky vyhledávání - "C. D. Haffner"

6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha.-Reductase and Human Adrenal 3.beta.-Hydroxy-.DELTA.5-steroid Dehydrogenase/3-Keto-.DELTA.5-steroid Isomerase

Autor: S V, Frye, C D, Haffner, P R, Maloney, R A, Mook, G F, Dorsey, R N, Hiner, C M, Cribbs, T N, Wheeler, J A, Ray, R C, Andrews

Publikováno v: Journal of Medicinal Chemistry. 37:2352-2360

6-Azaandrost-4-en-3-ones were synthesized and tested versus human type 1 and 2 steroid 5 alpha-reductase (5AR) and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase (3BHSD) to explore the structure-activity r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57b626d7f940ad779b99d6c7e77eee1
https://doi.org/10.1021/jm00041a014

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Origin of the preference for the chair conformation in the Cope rearrangement. Effect of phenyl substituents on the chair and boat transition states

Autor: Kenneth J. Shea, W. P. England, C. D. Haffner, G. J. Stoddard

Publikováno v: Journal of the American Chemical Society. 114:2635-2643

d,l- and meso-2,2'-bis[1-methylene-1,2,3,4-tetrahydronaphthalenes] 8 and 9 were synthesized, and the activation energy parameters for their unimolecular [3,3] sigmatropic rearrangement to 1,2-bis(3,4-dihydro-1-naphthalenyl)ethane (13) were determined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef9b081e4f780004409ec60b3e7aff90
https://doi.org/10.1021/ja00033a042

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6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase

Autor: S V, Frye, C D, Haffner, P R, Maloney, R A, Mook, G F, Dorsey, R N, Hiner, K W, Batchelor, H N, Bramson, J D, Stuart, S L, Schweiker

Publikováno v: Journal of medicinal chemistry. 36(26)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de93f2428cd1673df3ff62330191adc
https://pubmed.ncbi.nlm.nih.gov/8277514

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