Control of backbone chemistry and chirality boost oligonucleotide splice switching activity

Autor: Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam, Naoki Iwamoto, Jayakanthan Kumarasamy, Gopal R Bommineni, Adam Bezigian, Onanong Chivatakarn, David C D Butler, Michael Byrne, Katarzyna Chwalenia, Kay E Davies, Jigar Desai, Juili Dilip Shelke, Ann F Durbin, Ruth Ellerington, Ben Edwards, Jack Godfrey, Andrew Hoss, Fangjun Liu, Kenneth Longo, Genliang Lu, Subramanian Marappan, Jacopo Oieni, Ik-Hyeon Paik, Erin Purcell Estabrook, Chikdu Shivalila, Maeve Tischbein, Tomomi Kawamoto, Carlo Rinaldi, Joana Rajão-Saraiva, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Cong Zhou, Jason Zhang, Luciano Apponi, Matthew J A Wood, Chandra Vargeese

Publikováno v: Nucleic acids research. 50(10)

Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an advance for the splice-switching field, current SSO chemistries have shown limi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4563bb9a20823ec7e04b7dd2e362f73
https://pubmed.ncbi.nlm.nih.gov/35061895

Synthesis of 1‘-Substituted Derivatives of 1,2,3,4,5-Pentaphenylferrocene

Autor: David C. D. Butler, Christopher J. Richards

Publikováno v: Organometallics. 21:5433-5436

Pentaphenylferrocene was synthesized in 57% overall yield from 1-bromopentaphenylcyclopentadiene. Functionalization of the unsubstituted cyclopentadienyl ring using the Friedel−Crafts reaction gave 1‘-formyl- and 1‘-(2-chlorobenzoyl)-substitute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ba4b51446f67072bf7f01cd398fcaf8
https://doi.org/10.1021/om0204989

Planar chiral mimetics. A new approach to ligand design for asymmetric catalysis

Autor: David C. D. Butler, Geraint Jones, Christopher J. Richards

Publikováno v: Tetrahedron Letters. 41:9351-9354

(S)-Serine methyl ester is readily transformed into 4-(hydroxymethyl)oxazoline ligands containing either a 2-(η5-cyclopentadienyl)(η4-tetraphenylcyclobutadiene)cobalt or a 2-(1,2,3,4,5-pentaphenyl)-ferrocene substituent. The influence of the bulky

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf6ff517217f50d3ee2787c34ae525f8
https://doi.org/10.1016/s0040-4039(00)01715-9

Regioselective, Stereoselective, and Conformationally Controlled Synthesis of (η 4 -Tetraarylcyclobutadiene)(η 5 -carbomethoxycyclopentadienyl)cobalt Metallocenes

Autor: Elisabeth Nagaradja, Christopher J. Richards, Didier Villemin, David C. D. Butler, Doyle J. Cassar

Publikováno v: Organic Letters
Organic Letters, American Chemical Society, 2012, 14 (3), pp.894-897. ⟨10.1021/ol203415r⟩
Organic Letters, 2012, 14 (3), pp.894-897. ⟨10.1021/ol203415r⟩

The Friedel-Crafts reaction of (η(4)-tetraphenylcyclobutadiene)(η(5)-carbomethoxycyclopentadienyl)cobalt with acid chlorides/aluminum chloride resulted exclusively in para-phenyl acylation. Both monoacylated (1.1 equiv of RCOCl/AlCl(3)) and tetraac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ceb2c5923b53c7b4dd698ecd20d4174
https://hal.archives-ouvertes.fr/hal-01830112

Small Power Technology for Tetrahedral Rovers

Autor: C. D. Butler, P. E. Clark, S. R. Floyd, Y. Flom

Publikováno v: AIP Conference Proceedings.

The Small Power Technology (SPOT) being studied at GSFC has the potential to be an efficient and compact radioisotope based electrical power system. Such a system would provide power for innovative tetrahedral robotic arms and walkers to support the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ea8b2ca5e78e88614553e4b055af150
https://doi.org/10.1063/1.2169271