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Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast

Autor: M. Mitchell Smith, Jer-Yuan Hsu, C D Allis, Jung-Ae Kim

Publikováno v: Proceedings of the National Academy of Sciences. 109:5779-5784

A large body of literature provides compelling evidence for the role of evolutionarily conserved core histone residues in various biological processes. However, site-directed mutagenesis of individual residues that are known to be sites of posttransl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c8552ebbead3191b6c4378846abac2
https://doi.org/10.1073/pnas.1203453109

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Akademický článek

Endosomal Trafficking Bypassed by the RAB5B‐CD109 Interplay Promotes Axonogenesis in KRAS‐Mutant Pancreatic Cancer.

Autor: Zhang, Dingwen^1,2 (AUTHOR), Luo, Yuming² (AUTHOR), Lin, Yan^3,4 (AUTHOR), Fang, Zhou^2,5 (AUTHOR), Zheng, Hanhao^3,4 (AUTHOR), An, Mingjie^3,4 (AUTHOR), Xie, Qingyu^2,5 (AUTHOR), Wu, Zhuo^1,2 (AUTHOR), Yu, Chao^2,5 (AUTHOR), Yang, Jiabin^2,5 (AUTHOR), Yu, Min² (AUTHOR) yumin@gdph.org.cn, Chen, Changhao^3,4 (AUTHOR) chenchh53@mail.sysu.edu.cn, Chen, Rufu² (AUTHOR) chenrufu@gdph.org.cn

Publikováno v: Advanced Science. 12/18/2024, Vol. 11 Issue 47, p1-16. 16p.

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Akademický článek

Bmi‐1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone Aging.

Autor: Zhao, Jingyu¹ (AUTHOR), Chen, Ao¹ (AUTHOR), Wang, Rong¹ (AUTHOR), Qiu, Dong² (AUTHOR), Chen, Haiyun¹ (AUTHOR), Li, Jiyu¹ (AUTHOR), Zhang, Jin'ge¹ (AUTHOR), Wang, Tianxiao³ (AUTHOR), Wang, Yue¹ (AUTHOR), Lin, Yujie¹ (AUTHOR), Zhou, Jiawen¹ (AUTHOR), Du, Yifei² (AUTHOR), Yuan, Hua² (AUTHOR), Zhang, Yongjie¹ (AUTHOR), Miao, Dengshun¹ (AUTHOR), Wang, Yuli² (AUTHOR) njykdwyl@njmu.edu.cn, Jin, Jianliang¹ (AUTHOR) jinjianliang@njmu.edu.cn

Publikováno v: Advanced Science. 12/11/2024, Vol. 11 Issue 46, p1-21. 21p.

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Characterization of Tetrahymena Histone H2B Variants and Posttranslational Populations by Electron Capture Dissociation (ECD) Fourier Transform Ion Cyclotron Mass Spectrometry (FT-ICR MS)

Autor: Robert L. Diaz, C. D. Allis, Alma L. Burlingame, Michael J. Chalmers, Melinda A. McFarland, Alan G. Marshall, Xin Zhang, Shenheng Guan, Katalin F. Medzihradszky, Robert J. Chalkley

Publikováno v: Molecular & Cellular Proteomics. 3:872-886

This work describes the nature and sequence information content of the electron capture dissociation mass spectra for the intact Tetrahymena histone H2B. Two major variants of this protein were present bearing nominal modifications of both +42 and +8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc27ae8e3c1334594e498f333d95a31
https://doi.org/10.1074/mcp.m400041-mcp200

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GENT-44. LOWERED H3K27me3 AND DNA HYPOMETHYLATION DEFINE POORLY PROGNOSTIC PEDIATRIC POSTERIOR FOSSA EPENDYMOMAS

Publikováno v: Neuro-Oncology. 18:vi83-vi84

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cd6c9453f54f5190e835f7d7d0e3a6a
https://doi.org/10.1093/neuonc/now212.350

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Akademický článek

Design of a Bioluminescent Assay Platform for Quantitative Measurement of Histone Acetyltransferase Enzymatic Activity.

Autor: Swain ND; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, 30602, U.S.A., George Zheng Y; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, 30602, U.S.A.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Nov 22, pp. e202400692. Date of Electronic Publication: 2024 Nov 22.

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Increased Ser-10 Phosphorylation of Histone H3 in Mitogen-stimulated and Oncogene-transformed Mouse Fibroblasts

Autor: C P Tylipski, James R. Davie, Jim A. Wright, David P. Bazett-Jones, C D Allis, Deborah N. Chadee, Michael J. Hendzel

Publikováno v: Journal of Biological Chemistry. 274:24914-24920

When the Ras mitogen-activated protein kinase (MAPK) signaling pathway of quiescent cells is stimulated with growth factors or phorbol esters, the early response genes c-fos and c-myc are rapidly induced, and concurrently there is a rapid phosphoryla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241042ff8a4440bf392acaed072e4ab0
https://doi.org/10.1074/jbc.274.35.24914

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[Untitled]

Autor: Fred Winston, C D Allis

Publikováno v: Nature Structural Biology. 6:601-604

It has recently been demonstrated that bromodomains — motifs found in several eukaryotic transcription factors — bind to acetyl-lysine, a modification of histones that is important for transcription. This finding suggests that the regulatory effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f930482d4356ea21bad4d02e60b58f3
https://doi.org/10.1038/10640

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Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A

Autor: C D Allis, Jianxin Zhou, Gerhard Wagner, Yingxi Lin, C. M. Fletcher

Publikováno v: Nature. 400:86-89

Gene transcription requires the release of inactive DNA from its packaging of histone proteins. Following the discovery of the first transcription-associated histone acetyltransferase, tetrahymena GCN5, it was shown that yeast GCN5 is recruited to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6183390b5b984389f0a55782faaab532
https://doi.org/10.1038/21922

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