Zobrazeno 1 - 10 of 5 460 pro vyhledávání: '"C. Cole"'
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Effects of Very Low- and High-Frequency Subthalamic Stimulation on Motor Cortical Oscillations During Rhythmic Lower-Limb Movements in Parkinson’s Disease Patients
Autor: Taylor J. Bosch, Rachel C. Cole, Yarema Bezchlibnyk, Oliver Flouty, Arun Singh
Publikováno v: Journal of Parkinson's Disease. :1-14
Background: Standard high-frequency deep brain stimulation (HF-DBS) at the subthalamic nucleus (STN) is less effective for lower-limb motor dysfunctions in Parkinson’s disease (PD) patients. However, the effects of very low frequency (VLF; 4 Hz)-DB
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac6a3b9d29c3bcc890a349bc98995b79
https://doi.org/10.3233/jpd-225113
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Smoothelin-like 1 knockout mice display sex-dependent alterations in blood flow and cardiac function
Autor: Megha Murali, Sara R. Turner, Darrell D. Belke, William C. Cole, Justin A. MacDonald
Publikováno v: Canadian Journal of Physiology and Pharmacology. 101:27-40
Smoothelin-like 1 (SMTNL1) modulates the contractile performance of smooth muscle and thus has a key role in vascular homeostasis. Elevated vascular tone, recognized as a contributor to the development of progressive cardiac dysfunction, was previous
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d485a5e039cdbab594065dec357e55f
https://doi.org/10.1139/cjpp-2022-0172
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Dynamic Imine Bonding Facilitates Mannan Release from a Nanofibrous Peptide Hydrogel
Autor: Brett H. Pogostin, Gabriel Saenz, Carson C. Cole, Erin M. Euliano, Jeffrey D. Hartgerink, Kevin J. McHugh
Publikováno v: Bioconjugate Chemistry. 34:193-203
Recently, there has been increased interest in using mannan as an immunomodulatory bioconjugate. Despite notable immunological and functional differences between the reduced (R-Man) and oxidized (O-Man) forms of mannan, little is known about the impa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35c0be04ee440afd2cc2f3470cbd4da
https://doi.org/10.1021/acs.bioconjchem.2c00461
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A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios
Autor: Andreas Tosstorff, Markus G. Rudolph, Jason C. Cole, Michael Reutlinger, Christian Kramer, Hervé Schaffhauser, Agnès Nilly, Alexander Flohr, Bernd Kuhn
Publikováno v: Journal of Computer-Aided Molecular Design. 36:753-765
We release a new, high quality data set of 1162 PDE10A inhibitors with experimentally determined binding affinities together with 77 PDE10A X-ray co-crystal structures from a Roche legacy project. This data set is used to compare the performance of d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffb943fe62ae8f7b151926cb2e8bdee
https://doi.org/10.1007/s10822-022-00478-x
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