Hsp90 inhibitors enhance the antitumoral effect of osimertinib and overcome osimertinib resistance in non-small cell cell lung cancer cell models

Autor: C. Codony-Servat, M.A. Molina-Vila, Jillian Wilhelmina Paulina Bracht, Niki Karachaliou, Imane Chaib, Jordi Codony-Servat, Masahiro Ito, Rosa Rosell, Santiago Viteri

Publikováno v: Annals of Oncology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Background The epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) osimertinib improves therapy for non-small cell lung cancer (NSCLC) patients who possess EGR mutations. However, invariable acquired resistance appears due to severa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fa72bab799d70dd1b4544525a9c43e
https://doi.org/10.1093/annonc/mdz238.034

Triple MET/SRC/PIM inhibition in MET addicted tumors

Autor: Pierfranco Conte, Niki Karachaliou, Ilaria Attili, L. Bonanno, Masahiro Ito, Jean Cui, C. Codony-Servat, J.P. Bracht, Jordi Berenguer, Jordi Codony-Servat, Rosa Rosell

Publikováno v: Annals of Oncology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Background MET addicted tumors are known to show very short response to single MET inhibition. In MET addicted cells, MET inhibition leads to activation of proviral integration site for Moloney murine leukemia virus-1 (PIM1). PIM1 and SRC can regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01895ac6d5478aae8f94a5b00db40cd8
https://doi.org/10.1093/annonc/mdz268.094

P2.03-14 PKCi-PAK1 Pathway Modulates Sensitivity to Therapy in EGFR, KRAS Mutant and Squamous Cell Non-Small Cell Lung Cancer (NSCLC)

Autor: C. Codony-Servat, Jordi Codony-Servat, Jillian Wilhelmina Paulina Bracht, Nuno Gil, Masahiro Ito, Ilaria Attili, Rosa Rosell, Niki Karachaliou, Peng Cao, Morihito Okada, Jordi Berenguer

Publikováno v: Journal of Thoracic Oncology. 13:S721

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84616606b03a9d12786d07833141f0be
https://doi.org/10.1016/j.jtho.2018.08.1201

3PD Co-targeting PIM1 or Src to overcome the limits of single MET inhibition

Autor: Masahiro Ito, Rosa Rosell, Massimo Rugge, Ilaria Attili, C. Codony-Servat, Jillian Wilhelmina Paulina Bracht, Jordi Berenguer, Pierfranco Conte, Niki Karachaliou, L. Bonanno

Publikováno v: Journal of Thoracic Oncology. 13:S2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6400791aa0765badfb72ebad4e47f7b
https://doi.org/10.1016/s1556-0864(18)30283-1

P3.01-073 TPX-0005 with an EGFR Tyrosine Kinase Inhibitor (TKI) Overcomes Innate Resistance in EGFR Mutant NSCLC

Autor: S. Ignatius Ou, Jean Cui, X. Li, Peng Cao, J.M. Sánchez-Torres, A. Vergnenegre, Ana Giménez-Capitán, R. Garcia Campelo, Guillermo Lopez-Vivanco, Rosa Rosell, Antonio Passaro, J.C.-H. Yang, Jordi Berenguer, C. Codony Servat, J. Bratch, Enric Carcereny, A. Cardona, Santiago Viteri, M. Provencio, Imane Chaib, M.A. Molina-Vila, F. De Marinis, Noemí Reguart, Niki Karachaliou, J. Codony Servat, Ana Drozdowskyj

Publikováno v: Journal of Thoracic Oncology. 12:S2230

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e9ef0b605bd684bcb64f42a70ab6ef7
https://doi.org/10.1016/j.jtho.2017.09.1514