Zobrazeno 1 - 10
of 219
pro vyhledávání: '"C. Christianson"'
Autor:
Keiji Kurata, Anna-James Bott, Mark A. Tye, Leona Yamamoto, Mehmet K. Samur, Yu-Tzu Tai, James Dunford, Catrine Johansson, Filiz Senbabaoglu, Martin Philpott, Charlotte Palmer, Karthik Ramasamy, Sarah Gooding, Mihaela Smilova, Giorgia Gaeta, Manman Guo, John C. Christianson, N. Connor Payne, Kritika Singh, Kubra Karagoz, Matthew E. Stokes, Maria Ortiz, Patrick Hagner, Anjan Thakurta, Adam Cribbs, Ralph Mazitschek, Teru Hideshima, Kenneth C. Anderson, Udo Oppermann
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Multiple myeloma (MM) is a plasma cell malignancy characterised by aberrant production of immunoglobulins requiring survival mechanisms to adapt to proteotoxic stress. We here show that glutamyl-prolyl-tRNA synthetase (GluProRS) inhibition c
Externí odkaz:
https://doaj.org/article/9a68487f85794fbbb8d94c8c96041cdb
Autor:
Keiji Kurata, Anna James-Bott, Mark A. Tye, Leona Yamamoto, Mehmet K. Samur, Yu-Tzu Tai, James Dunford, Catrine Johansson, Filiz Senbabaoglu, Martin Philpott, Charlotte Palmer, Karthik Ramasamy, Sarah Gooding, Mihaela Smilova, Giorgia Gaeta, Manman Guo, John C. Christianson, N. Connor Payne, Kritika Singh, Kubra Karagoz, Matthew E. Stokes, Maria Ortiz, Patrick Hagner, Anjan Thakurta, Adam Cribbs, Ralph Mazitschek, Teru Hideshima, Kenneth C. Anderson, Udo Oppermann
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/6051b2d4f43d4b03bb7dd172ab4fd63a
Autor:
Simon R. Bushell, Ashley C. W. Pike, Maria E. Falzone, Nils J. G. Rorsman, Chau M. Ta, Robin A. Corey, Thomas D. Newport, John C. Christianson, Lara F. Scofano, Chitra A. Shintre, Annamaria Tessitore, Amy Chu, Qinrui Wang, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, James D. Love, Nicola A. Burgess-Brown, Rebecca Sitsapesan, Phillip J. Stansfeld, Juha T. Huiskonen, Paolo Tammaro, Alessio Accardi, Elisabeth P. Carpenter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
TMEM16K is a member of the TMEM16 family of integral membrane proteins that are either lipid scramblases or chloride channels. Here the authors combine cell biology, electrophysiology measurements, X-ray crystallography, cryo-EM and MD simulations to
Externí odkaz:
https://doaj.org/article/602dd2cc133c49529d8807b7b0d875ca
Autor:
Emma J Fenech, Federica Lari, Philip D Charles, Roman Fischer, Marie Laétitia-Thézénas, Katrin Bagola, Adrienne W Paton, James C Paton, Mads Gyrd-Hansen, Benedikt M Kessler, John C Christianson
Publikováno v:
eLife, Vol 9 (2020)
Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate essential cellular activities including protein quality control, calcium flux, and sterol homeostasis. At least 25 different, transmembrane domain (TMD)-containing E
Externí odkaz:
https://doaj.org/article/1e66b996a9fb4681a2ea07de56be7231
Autor:
Milena Vitale, Anush Bakunts, Andrea Orsi, Federica Lari, Laura Tadè, Alberto Danieli, Claudia Rato, Caterina Valetti, Roberto Sitia, Andrea Raimondi, John C Christianson, Eelco van Anken
Publikováno v:
eLife, Vol 8 (2019)
How endoplasmic reticulum (ER) stress leads to cytotoxicity is ill-defined. Previously we showed that HeLa cells readjust homeostasis upon proteostatically driven ER stress, triggered by inducible bulk expression of secretory immunoglobulin M heavy c
Externí odkaz:
https://doaj.org/article/1fadbf5d07454278a95cd18f5e2395cb
Autor:
E. Bourseau-Guilmain, J. A. Menard, E. Lindqvist, V. Indira Chandran, H. C. Christianson, M. Cerezo Magaña, J. Lidfeldt, G. Marko-Varga, C. Welinder, M. Belting
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Hypoxia promotes tumour aggressiveness and resistance of cancers to oncological treatment. Here, the authors show that caveolin-1 can down-regulate global membrane protein endocytosis in hypoxic cells with potential implications for targeting the hyp
Externí odkaz:
https://doaj.org/article/1e1a53f7a7094b50bafa7b8b8e2815da
Autor:
Mattias Belting, Karin Forsberg-Nilsson, Toin H. van Kuppevelt, Helena C. Christianson, Myriam Cerezo-Magaña
(A) Characterization of U87 MG-derived EVs. Immunoblotting for typical EV markers (CD9, CD63, TSG101) and control proteins (EEA1, GM130, α-tubulin, calnexin) in cell lysate (CL) and isolated EVs (EV). Equal total protein was loaded from CL and EVs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57913e45e2cb24da4746d0cdd05c75da
https://doi.org/10.1158/1541-7786.22526084
https://doi.org/10.1158/1541-7786.22526084
Autor:
Mattias Belting, Karin Forsberg-Nilsson, Toin H. van Kuppevelt, Helena C. Christianson, Myriam Cerezo-Magaña
As an adaptive response to hypoxic stress, aggressive tumors rewire their metabolic phenotype into increased malignant behavior through extracellular lipid scavenging and storage in lipid droplets (LD). However, the underlying mechanisms and potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12b20b4e4dd7ad0f667b43a84b92eb9c
https://doi.org/10.1158/1541-7786.c.6544997.v1
https://doi.org/10.1158/1541-7786.c.6544997.v1
Autor:
Mattias Belting, Karin Forsberg-Nilsson, Toin H. van Kuppevelt, Helena C. Christianson, Myriam Cerezo-Magaña
High-resolution Airyscan live-cell confocal microscopy visualization of EV and CtxB co-internalization. The sequence was captured at 1.5 min interval for 45 min. Scale bar, 20 µm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3962e6888048b5c2c30b91af9a1636eb
https://doi.org/10.1158/1541-7786.22526066.v1
https://doi.org/10.1158/1541-7786.22526066.v1
Autor:
Mattias Belting, Maria C. Johansson, Johan Bengzon, Charlotte Welinder, Lena Kjellén, Vineesh Indira Chandran, Eva Lindqvist, Katrin J. Svensson, Erika Bourseau-Guilmain, Paulina Kucharzewska, Helena C. Christianson, Julien A. Menard
Figure S3. A,B, Increased lipoprotein uptake by hypoxia in several cell types. C, Temperature-dependent uptake of lipoproteins. D, Competitive inhibition of DiI-labelled lipoprotein uptake. E and F, Hypoxia does not induce macropinocytosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2a964343b5ac525eeefcc888d96948
https://doi.org/10.1158/0008-5472.22403549
https://doi.org/10.1158/0008-5472.22403549