Zobrazeno 1 - 10
of 238
pro vyhledávání: '"C. Chris Yun"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 695-716 (2022)
Background & Aims: Diarrhea is one of the most common illnesses and is often caused by bacterial infection. Recently, we have shown that human Na+/H+ exchanger NHE3 (hNHE3), but not non-human NHE3s, interacts with the E3 ubiquitin ligase Nedd4-2. We
Externí odkaz:
https://doaj.org/article/311867a552d84d178a25a8b1d43ff2d4
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 14, Iss 1, Pp 129-150 (2022)
Background & Aims: Regeneration of the epithelium by stem cells in the intestine is supported by intrinsic and extrinsic factors. Lysophosphatidic acid (LPA), a bioactive lipid mediator, regulates many cellular functions, including cell proliferation
Externí odkaz:
https://doaj.org/article/74e2be401f094fb38e266362982fa041
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1073-1092 (2021)
Background & Aims: Epithelial cells form a monolayer at mucosal surface that functions as a highly selective barrier. Lysophosphatidic acid (LPA) is a bioactive lipid that elicits a broad range of biological effects via cognate G protein-coupled rece
Externí odkaz:
https://doaj.org/article/7f9031786e544050bf9cd93dac654d00
Autor:
Yiran Han, C. Chris Yun
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Glycemic control is the key to the management of type 2 diabetes. Metformin is an effective, widely used drug for controlling plasma glucose levels in diabetes, but it is often the culprit of gastrointestinal adverse effects such as abdominal pain, n
Externí odkaz:
https://doaj.org/article/e7a5acbfcbde4d4a80fa2e5ac71aafe1
Autor:
Zhongxing Liang, C. Chris Yun
Publikováno v:
Cells, Vol 11, Iss 14, p 2243 (2022)
Renewal of the intestinal epithelium is orchestrated by regenerative epithelial proliferation within crypts. Recent studies have shown that lysophosphatidic acid (LPA) can maintain intestinal epithelial renewal in vitro and conditional deletion of Lp
Externí odkaz:
https://doaj.org/article/1851ca7391134b908e0ba94e5ecaca55
Autor:
C. Chris Yun
Publikováno v:
Cancers, Vol 11, Iss 7, p 958 (2019)
The intestinal epithelium interacts dynamically with the immune system to maintain its barrier function to protect the host, while performing the physiological roles in absorption of nutrients, electrolytes, water and minerals. The importance of lyso
Externí odkaz:
https://doaj.org/article/d5e3a9329b054d27b817cb74e4dd608c
Autor:
Ayesha Sultan, Min Luo, Qin Yu, Brigitte Riederer, Weiliang Xia, Mingmin Chen, Simone Lissner, Johannes E. Gessner, Mark Donowitz, C. Chris Yun, Hugo deJonge, Georg Lamprecht, Ursula Seidler
Publikováno v:
Cellular Physiology and Biochemistry, Vol 32, Iss 5, Pp 1386-1402 (2013)
Background/Aims: Trafficking, brush border membrane (BBM) retention, and signal-specific regulation of the Na+/H+ exchanger NHE3 is regulated by the Na+/H+ Exchanger Regulatory Factor (NHERF) family of PDZ-adaptor proteins, which enable the formation
Externí odkaz:
https://doaj.org/article/773eeb0af0df463496aea9b705e8c0b5
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 695-716 (2022)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Diarrhea is one of the most common illnesses and is often caused by bacterial infection. Recently, we have shown that human Na+/H+ exchanger NHE3 (hNHE3), but not non-human NHE3s, interacts with the E3 ubiquitin ligase Nedd4-2. We h
Autor:
C. Chris Yun, Yiran Han
Publikováno v:
FASEB J
Na(+)/H(+) exchanger NHE3 of human or primates differs from NHE3 of other animals by having a PY motif, which mediates interaction with the E3 ubiquitin (Ub) ligase Nedd4–2. Ub-conjugation of human NHE3 by Nedd4–2 regulates endocytosis of NHE3 bu
Autor:
Yiran, Han, C Chris, Yun
Publikováno v:
Frontiers in physiology. 13
Glycemic control is the key to the management of type 2 diabetes. Metformin is an effective, widely used drug for controlling plasma glucose levels in diabetes, but it is often the culprit of gastrointestinal adverse effects such as abdominal pain, n