Zobrazeno 1 - 10
of 44
pro vyhledávání: '"C. Chandra Kumar"'
Publikováno v:
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2023, Vol. 14 Issue 6, p1056-1061, 6p
Publikováno v:
International Journal of Contemporary Surgery; Jul-Dec2019, Vol. 7 Issue 2, p125-131, 7p
Autor:
Joseph E. Myers, Zhizhang Yin, Ahmed A. Samatar, William T. Windsor, Rosalinda Syto, Zhuomei Lu, Sandra Koseoglu, C. Chandra Kumar, Paul Kirschmeier, Todd Mayhood, Jill M. Stafford, Tammy C. Turek-Etienne, Linda James, Bruce A. Malcolm
Publikováno v:
SLAS Discovery. 9:309-321
Most of the protein kinase inhibitors being developed are directed toward the adenosine triphosphate (ATP) binding site that is highly conserved in many kinases. A major issue with these inhibitors is the specificity for a given kinase. Structure det
Autor:
C. Chandra Kumar
Publikováno v:
Current Drug Targets. 4:123-131
The integrin receptor alphavbeta3 has been shown to play a critical role in several distinct processes, such as angiogenesis, osteoclast-mediated bone resorption and tumor metastasis. Its expression is upregulated in newly synthesized blood vessels p
Publikováno v:
Journal of Biological Chemistry. 277:28118-28126
Tumors evade cell death by constitutively activating cell survival pathways and suppressing intrinsic death machinery. Activation of cell survival pathways leads to transcriptional repression of genes associated with cell death and activation of ones
Autor:
C. Chandra Kumar, Vincent Madison
Publikováno v:
Expert Opinion on Emerging Drugs. 6:303-315
Current treatments for cancer (surgery, radiation and chemotherapy) are successful for early stage localised disease but have severe side effects. New treatments are needed to increase the cure rate and life expectancy of patients. With the discovery
Publikováno v:
Experimental Cell Research. 251:33-45
The alpha(v)beta(3) integrin mediates endothelial cell binding to the extracellular matrix and transduces an intracellular signal promoting survival of endothelial cells and various tumor cells. While the alpha(v)beta(3) integrin-mediated survival si
Autor:
Kiyoko Fukami, Richard J. Simpson, Takeshi Watanabe, Cai Huang, Hiroshi Maruta, Tadaomi Takenawa, C. Chandra Kumar, Hong S. He, Xi Zhan, Ed Schuuring
Publikováno v:
Scopus-Elsevier
Oncogenic Ras mutants such as v-Ha-Ras cause a rapid rearrangement of actin cytoskeleton during malignant transformation of fibroblasts or epithelial cells. Both PI-3 kinase and Rac are required for Ras-induced malignant transformation and membrane r
Autor:
Katherine A Comer, Phillip A. Dennis, C. Chandra Kumar, Joseph J. Catino, Michael B. Kastan, Lydia Armstrong
Publikováno v:
Oncogene. 16:1299-1308
Smooth muscle (sm) alpha-actin is expressed in vascular smooth muscle cells and fibroblast cells. Its expression is regulated by cell proliferation and repressed during oncogenic transformation. In this study, we demonstrate that p53 activation is as
Autor:
Joseph J. Catino, C. Chandra Kumar, Nancy E. Robertson, Jae Hong Kim, Ron Prywes, Finn Eirik Johansen
Publikováno v:
Journal of Biological Chemistry. 269:13740-13743
Serum response factor (SRF) is a nuclear transcription factor that binds to the serum response element (SRE) found in the promoter regions of a number of growth factor-inducible genes, as well as muscle-specific genes. The smooth muscle alpha-actin p