Zobrazeno 1 - 10
of 33
pro vyhledávání: '"C. C. Sigman"'
Autor:
V. E. Steele, D. Bagheri, D. A. Balentine, C. W. Boone, R. Mehta, M. A. Morse, S. Sharma, C. C. Sigman, G. D. Stoner, M. J. Wargovich, J. H. Weisburger, S. Zhu, G. J. Kelloff
Publikováno v:
Experimental Biology and Medicine. 220:210-212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e649b63e6b65f1b77328bad24fae95d6
https://doi.org/10.3181/00379727-220-44367
https://doi.org/10.3181/00379727-220-44367
Autor:
G. J. Kelloff, C. C. Sigman
Publikováno v:
Mechanisms in Carcinogenesis and Cancer Prevention ISBN: 9783642078590
The potential role of products of arachidonic acid (AA) metabolism in carcinogenesis has been reviewed extensively (Kelloff et al. 1994; Marnett 1995; Taketo 1998a,b; Dannenberg et al. 2001; Funk 2001), as have cancer prevention strategies based on m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c4501b2f3ba3d6aba872f397694d9c8
https://doi.org/10.1007/978-3-662-08602-5_11
https://doi.org/10.1007/978-3-662-08602-5_11
Publikováno v:
IARC scientific publications. 154
Relevant and feasible surrogate end-points are needed for the evaluation of intervention strategies against cancer and other chronic, life-threatening diseases. Carcinogenesis can be viewed as a process of progressive disorganization. This process is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa48350b6be9f12ca1a986d487c8a48d
https://pubmed.ncbi.nlm.nih.gov/11220652
https://pubmed.ncbi.nlm.nih.gov/11220652
Publikováno v:
Carcinogenesis. 21(7)
Retinoids are essential for the maintenance of epithelial differentiation. As such, they play a fundamental role in chemoprevention of epithelial carcinogenesis and in differentiation therapy. Physiological retinoic acid is obtained through two oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d14f82740f0c5ae5a89d3d283e13f7b9
https://pubmed.ncbi.nlm.nih.gov/10874003
https://pubmed.ncbi.nlm.nih.gov/10874003
Publikováno v:
European journal of cancer (Oxford, England : 1990). 35(14)
Cancer chemoprevention is the use of agents to inhibit, delay or reverse carcinogenesis. The focus of chemoprevention research in the next millennium will include defining the genotypic and phenotypic (functional and histological) changes during carc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d050fbb175df570642b7e8e2f09404c6
https://pubmed.ncbi.nlm.nih.gov/10711244
https://pubmed.ncbi.nlm.nih.gov/10711244
Autor:
G J, Kelloff, C C, Sigman, K M, Johnson, C W, Boone, P, Greenwald, J A, Crowell, E T, Hawk, L A, Doody
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 9(2)
This paper proposes a scientific basis and possible strategy for applying surrogate end points in chemopreventive drug development. The potential surrogate end points for cancer incidence described are both phenotypic (at the tissue, cellular, and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::513c2563bc853588d6f77e3b32be2dbf
https://pubmed.ncbi.nlm.nih.gov/10698472
https://pubmed.ncbi.nlm.nih.gov/10698472
Autor:
V E, Steele, C A, Holmes, E T, Hawk, L, Kopelovich, R A, Lubet, J A, Crowell, C C, Sigman, G J, Kelloff
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 8(5)
Mounting evidence suggests that lipoxygenase (LO)-catalyzed products have a profound influence on the development and progression of human cancers. Compared with normal tissues, significantly elevated levels of LO metabolites have been found in lung,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b74b7ec791c1388a389ffa4abbfbd5a
https://pubmed.ncbi.nlm.nih.gov/10350444
https://pubmed.ncbi.nlm.nih.gov/10350444
Publikováno v:
Clinical chemistry. 44(2)
Recently, several promising strategies have been advanced for improving the efficiency of new agent development. These include pharmacokinetic/pharmacodynamic (PK/PD) and intermediate endpoint biomarker (IEB) monitoring. Here, we review their essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4942550c65d1726a45512a43bdcfdd27
https://pubmed.ncbi.nlm.nih.gov/9474054
https://pubmed.ncbi.nlm.nih.gov/9474054
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 6(4)
Among the most important targets for chemopreventive intervention and drug development are deregulated signal transduction pathways. Ras proteins serve as central connectors between signals generated at the plasma membrane and nuclear effectors; thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4d0d6d31e1db003bb701af81b010b29
https://pubmed.ncbi.nlm.nih.gov/9107432
https://pubmed.ncbi.nlm.nih.gov/9107432
Autor:
G J, Kelloff, E T, Hawk, J E, Karp, J A, Crowell, C W, Boone, V E, Steele, R A, Lubet, C C, Sigman
Publikováno v:
Seminars in oncology. 24(2)
Chemoprevention has four goals: (1) inhibition of carcinogens, (2) logical intervention for persons at genetic risk for cancer, (3) treatment of precancerous lesions, and (4) confirmation and translation of leads from dietary epidemiology into interv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8396df44130cf9ada8a018e80dd855a
https://pubmed.ncbi.nlm.nih.gov/9129692
https://pubmed.ncbi.nlm.nih.gov/9129692