Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis

Autor: Carina Prip-Buus, Isabel Tavares de Almeida, Lodewijk IJlst, Margarida F. B. Silva, C. C. P. Aires, Marinus Duran, Femke S. Stet, Ronald J.A. Wanders

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2010, 79 (5), pp.792-799. ⟨10.1016/j.bcp.2009.10.011⟩
Biochemical pharmacology, 79(5), 792-799. Elsevier Inc.

Background/Aims: Carnitine Palmitoyl-transferase I (CPT I) catalyses the synthesis of long-chain (LC)-acylcarnitines from LC-acyl-CoA esters. It is the rate-limiting enzyme of mitochondrial fatty acid, beta-oxidation (FAO) pathway and its activity is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b11a427753f1ae8127c34e744833f1e
https://doi.org/10.1016/j.bcp.2009.10.011

Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes

Autor: Herman J. ten Brink, Paula B.M. Luís, Ronald J.A. Wanders, Isabel Tavares de Almeida, Margarida F. B. Silva, Marinus Duran, C. C. P. Aires, Graça Soveral

Publikováno v: FEBS letters, 582(23-24), 3359-3366. Wiley-Blackwell
Aires, C C P, Soveral, G, Luis, P B M, ten Brink, H J, Tavares de Almeida, I, Duran, M, Wanders, R J A & Silva, M F B 2008, ' Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes ', FEBS Letters, vol. 582, no. 23-24, pp. 3359-3366 . https://doi.org/10.1016/j.febslet.2008.08.028
FEBS Letters, 582(23-24), 3359-3366. Wiley-Blackwell
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

The pyruvate uptake rate in inverted submitochondrial vesicles prepared from rat liver was optimized and further characterized; the potential inhibitory effects of the anticonvulsive drug valproic acid or 2-n-propyl-pentanoic acid (VPA), Delta(4)-val

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb3a5a2ccc6bc51f7850dbca0c18f4d
https://hdl.handle.net/10451/21628

Studies on the extra-mitochondrial CoA-ester formation of valproic and Delta(4)-valproic acids

Autor: Jos P.N. Ruiter, Paula B.M. Luís, C. C. P. Aires, Marinus Duran, Lodewijk IJlst, Herman J. ten Brink, Isabel Tavares de Almeida, Margarida F. B. Silva, Ronald J.A. Wanders

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1771(4), 533-543. Elsevier

The hypothesis whether valproic acid (VPA) and its main microsomal metabolite, Delta(4)-valproic acid, can be activated to the respective CoA esters in the cell cytosol was investigated. The valproyl-CoA formation was measured in different subcellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b944b53fb96b7538e4335a9db842d4
https://hdl.handle.net/10451/21620