Zobrazeno 1 - 10
of 641
pro vyhledávání: '"C. Burnham"'
Autor:
Yoshiki Niimi, Shorena Janelidze, Kenichiro Sato, Naoki Tomita, Tadashi Tsukamoto, Takashi Kato, Kenji Yoshiyama, Hisatomo Kowa, Atsushi Iwata, Ryoko Ihara, Kazushi Suzuki, Kensaku Kasuga, Takeshi Ikeuchi, Kenji Ishii, Kengo Ito, Akinori Nakamura, Michio Senda, Theresa A. Day, Samantha C. Burnham, Leonardo Iaccarino, Michael J. Pontecorvo, Oskar Hansson, Takeshi Iwatsubo
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Maximizing the efficiency to screen amyloid-positive individuals in asymptomatic and non-demented aged population using blood-based biomarkers is essential for future success of clinical trials in the early stage of Alzheimer’s
Externí odkaz:
https://doaj.org/article/d12e8157ca6b40da9d6b4f81cfd4802f
Autor:
Mischa Lundberg, Letitia M. F. Sng, Piotr Szul, Rob Dunne, Arash Bayat, Samantha C. Burnham, Denis C. Bauer, Natalie A. Twine
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Alzheimer’s disease (AD) is a complex genetic disease, and variants identified through genome-wide association studies (GWAS) explain only part of its heritability. Epistasis has been proposed as a major contributor to this ‘missing heri
Externí odkaz:
https://doaj.org/article/23a79e7ac1bf4883a953d53afd8f353a
Autor:
Michael Vacher, Vincent Doré, Tenielle Porter, Lidija Milicic, Victor L. Villemagne, Pierrick Bourgeat, Sam C. Burnham, Timothy Cox, Colin L. Masters, Christopher C. Rowe, Jurgen Fripp, James D. Doecke, Simon M. Laws
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background With a growing number of loci associated with late-onset (sporadic) Alzheimer’s disease (AD), the polygenic contribution to AD is now well established. The development of polygenic risk score approaches have shown promising resu
Externí odkaz:
https://doaj.org/article/922fd30cfa5d4aa2bb78f823a53ae0a8
Autor:
Natasha Krishnadas, Vincent Doré, Colin Groot, Fiona Lamb, Pierrick Bourgeat, Samantha C. Burnham, Kun Huang, Anita M. Y. Goh, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe, for the AIBL research group
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract Background Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau de
Externí odkaz:
https://doaj.org/article/29865099cabe401bb295621f4d6488e7
Autor:
Rosita Shishegar, Timothy Cox, David Rolls, Pierrick Bourgeat, Vincent Doré, Fiona Lamb, Joanne Robertson, Simon M. Laws, Tenielle Porter, Jurgen Fripp, Duygu Tosun, Paul Maruff, Greg Savage, Christopher C. Rowe, Colin L. Masters, Michael W. Weiner, Victor L. Villemagne, Samantha C. Burnham
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract To improve understanding of Alzheimer’s disease, large observational studies are needed to increase power for more nuanced analyses. Combining data across existing observational studies represents one solution. However, the disparity of su
Externí odkaz:
https://doaj.org/article/42fdcdd7f3cb4cf2a359b106d65ccf69
Autor:
Pierrick Bourgeat, Vincent Doré, Samantha C. Burnham, Tammie Benzinger, Duygu Tosun, Shenpeng Li, Manu Goyal, Pamela LaMontagne, Liang Jin, Christopher C Rowe, Michael W. Weiner, John C Morris, Colin L Masters, Jurgen Fripp, Victor L Villemagne
Publikováno v:
NeuroImage, Vol 262, Iss , Pp 119527- (2022)
Introduction: The Centiloid scale was developed to harmonise the quantification of β-amyloid (Aβ) PET images across tracers, scanners, and processing pipelines. However, several groups have reported differences across tracers and scanners even afte
Externí odkaz:
https://doaj.org/article/128cc763d3534e119f8b75294ba84d3d
Autor:
Alexis C. Burnham, Laura Ordeix, M. Magdalena Alcover, Pamela Martínez-Orellana, Sara Montserrat-Sangrà, Laura Willen, Tatiana Spitzova, Petr Volf, Laia Solano-Gallego
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Background Canine leishmaniosis caused by Leishmania infantum is a neglected zoonosis transmitted by sand flies like Phlebotomus perniciosus. Clinical signs and disease susceptibility vary according to various factors, including host immune
Externí odkaz:
https://doaj.org/article/0ae4cdd566644145be03f8a8c516272a
Autor:
James D. Doecke, Larry Ward, Samantha C. Burnham, Victor L. Villemagne, Qiao-Xin Li, Steven Collins, Christopher J. Fowler, Ekaterina Manuilova, Monika Widmann, Stephanie R. Rainey-Smith, Ralph N. Martins, Colin L. Masters, the AIBL Research Group
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Abstract Background β-amyloid (Aβ) positron emission tomography (PET) imaging is currently the only Food and Drug Administration-approved method to support clinical diagnosis of Alzheimer’s disease (AD). However, numerous research studies support
Externí odkaz:
https://doaj.org/article/ca236dd529884d0a927880e177f12915
Autor:
Tenielle Porter, Samantha C. Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Hamid R. Sohrabi, Madeline Peretti, Yen Ying Lim, Michael Weinborn, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L. Villemagne, Simon M. Laws
Publikováno v:
IBRO Reports, Vol 6, Iss , Pp 147-152 (2019)
The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to inves
Externí odkaz:
https://doaj.org/article/d6cf29c4ce3b4e168101e5fda282608d
Autor:
Henrik Zetterberg, Samantha C. Burnham
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-7 (2019)
Abstract A major barrier to the effective conduct of clinical trials of new drug candidates against Alzheimer’s disease (AD) and to identifying patients for receiving future disease-modifying treatments is the limited capacity of the current health
Externí odkaz:
https://doaj.org/article/e2ff49deb38143f980edacb410b15cc2