Zobrazeno 1 - 10
of 106
pro vyhledávání: '"C. Brombacher"'
Autor:
Hendrik J.P. vanderZande, Eline C. Brombacher, Joost M. Lambooij, Leonard R. Pelgrom, Anna Zawistowska-Deniziak, Thiago A. Patente, Graham A. Heieis, Frank Otto, Arifa Ozir-Fazalalikhan, Maria Yazdanbakhsh, Bart Everts, Bruno Guigas
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Obesity-associated metabolic inflammation drives the development of insulin resistance and type 2 diabetes, notably through modulating innate and adaptive immune cells in metabolic organs. The nutrient sensor liver kinase B1 (LKB1) has recently been
Externí odkaz:
https://doaj.org/article/a2a53ade54994d4e8b65b8433ec93d8d
Autor:
Karin D. Prummel, Helena L. Crowell, Susan Nieuwenhuize, Eline C. Brombacher, Stephan Daetwyler, Charlotte Soneson, Jelena Kresoja-Rakic, Agnese Kocere, Manuel Ronner, Alexander Ernst, Zahra Labbaf, David E. Clouthier, Anthony B. Firulli, Héctor Sánchez-Iranzo, Sundar R. Naganathan, Rebecca O’Rourke, Erez Raz, Nadia Mercader, Alexa Burger, Emanuela Felley-Bosco, Jan Huisken, Mark D. Robinson, Christian Mosimann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
The mesothelium supports homeostasis and regeneration, yet its development origins remain unclear. Here, the authors uncovered the earliest mesothelium progenitor cells in zebrafish, linking Hand2 gene function to mesothelium formation and its re-act
Externí odkaz:
https://doaj.org/article/445f40166b9345a1905f77ae35cd17f3
Autor:
Karin D. Prummel, Christopher Hess, Susan Nieuwenhuize, Hugo J. Parker, Katherine W. Rogers, Iryna Kozmikova, Claudia Racioppi, Eline C. Brombacher, Anna Czarkwiani, Dunja Knapp, Sibylle Burger, Elena Chiavacci, Gopi Shah, Alexa Burger, Jan Huisken, Maximina H. Yun, Lionel Christiaen, Zbynek Kozmik, Patrick Müller, Marianne Bronner, Robb Krumlauf, Christian Mosimann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Numerous tissues are derived from the lateral plate mesoderm (LPM) but how this is specified is unclear. Here, the authors identify a pan-LPM reporter activity found in the zebrafish draculin (drl) gene that also shows transgenic activity in LPM-corr
Externí odkaz:
https://doaj.org/article/cfe6d2cea11f4fa1bf72c26475a34643
Autor:
Anastasia Felker, Karin D. Prummel, Anne M. Merks, Michaela Mickoleit, Eline C. Brombacher, Jan Huisken, Daniela Panáková, Christian Mosimann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Late-differentiating second heart field progenitors contribute to atrium, ventricle, and outflow tract in the zebrafish heart but how remains unclear. Here, the authors image heart formation in transgenics based on the cardiopharyngeal gene tbx1 and
Externí odkaz:
https://doaj.org/article/e71f9bcf345740a2b3c7a33df90e5e7d
Autor:
Keh-Weei Tzung, Robert L. Lalonde, Karin D. Prummel, Harsha Mahabaleshwar, Hannah R. Moran, Jan Stundl, Amanda N. Cass, Yao Le, Robert Lea, Karel Dorey, Monika J. Tomecka, Changqing Zhang, Eline C. Brombacher, William T. White, Henry H. Roehl, Frank J. Tulenko, Christoph Winkler, Peter D. Currie, Enrique Amaya, Marcus C. Davis, Marianne E. Bronner, Christian Mosimann, Tom J. Carney
Publikováno v:
Nature.
The development of paired appendages was a key innovation during evolution and facilitated the aquatic to terrestrial transition of vertebrates. Largely derived from the lateral plate mesoderm (LPM), one hypothesis for the evolution of paired fins in
Autor:
Thiago A Patente, Eline C Brombacher, Graham A Heieis, Leonard R Pelgrom, Anna Zawistowska-Deniziak, Frank Otto, Arifa Ozir-Fazalalikhan, Alwin J van der Ham, Bruno A Guigas, José AM Barbuto, Bart Everts
Dendritic cells (DCs) play a crucial role in promoting tolerance through priming of regulatory T cells (Treg). Several studies indicate DC tolerogenicity is dependent on catabolic metabolism. However, the role of AMP-activated Kinase (AMPK), a key en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::591ea410013e3f3000f4a1242478ce0f
https://doi.org/10.1101/2023.02.21.528293
https://doi.org/10.1101/2023.02.21.528293
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a56498c7acfa1eee576a89aecc63048
https://doi.org/10.1007/978-1-0716-2938-3_16
https://doi.org/10.1007/978-1-0716-2938-3_16
Autor:
Eline C. Brombacher, Boudewijn M.T. Burgering, M. Pages Gallego, Marlies C. Ludikhuize, Maaike Meerlo, Jihye Paik, M. J. Rodriguez Colman, Nhu T. Nguyen, M. Burgaya Julia
SummaryDifferential signalling of the WNT and Notch pathways regulates proliferation and differentiation of Lgr5+crypt-based columnar cells (CBCs) into all cell lineages of the intestine. We have recently shown that high mitochondrial activity in CBC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e0dbd714c3b001d94498e8f1162a11
Autor:
Eline C. Brombacher, Alexa Burger, Zbynek Kozmik, Katherine W Rogers, Hugo J. Parker, Patrick Müller, Gopi Shah, Karin D. Prummel, Iryna Kozmikova, Claudia Racioppi, Maximina H. Yun, Robb Krumlauf, Anna Czarkwiani, Sibylle Burger, Marianne E. Bronner, Christian Mosimann, Lionel Christiaen, Christopher P. Hess, Elena Chiavacci, Dunja Knapp, Jan Huisken, Susan Nieuwenhuize
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Cardiovascular lineages develop together with kidney, smooth muscle, and limb connective tissue progenitors from the lateral plate mesoderm (LPM). How the LPM initially emerges and how its downstream fates are molecularly interconnected remain unknow
Autor:
Maaike Meerlo, Eline C. Brombacher, Jihye Paik, Boudewijn M.T. Burgering, Mar Burgaya Julia, Marc Pages Gallego, Maria J. Rodriguez Colman, Nhu T. Nguyen, Marlies C. Ludikhuize
Publikováno v:
SSRN Electronic Journal.
Differential signalling of the WNT and Notch pathways regulates proliferation and differentiation of Lgr5+ crypt-based columnar cells (CBCs) into all cell lineages of the intestine. We have recently shown that high mitochondrial activity in CBCs is k