Zobrazeno 1 - 10
of 1 491
pro vyhledávání: '"C. Bonamy"'
Publikováno v:
Flow, Vol 3 (2023)
In submerged sandy slopes, soil is frequently eroded as a combination of two main mechanisms: breaching, which refers to the retrogressive failure of a steep slope forming a turbidity current, and instantaneous sliding wedges, known as shear failure,
Externí odkaz:
https://doaj.org/article/25086082e06640629f1073b7b9c27e84
Publikováno v:
Geoscientific Model Development, Vol 10, Pp 4367-4392 (2017)
In this paper, a three-dimensional two-phase flow solver, SedFoam-2.0, is presented for sediment transport applications. The solver is extended from twoPhaseEulerFoam available in the 2.1.0 release of the open-source CFD (computational fluid dynam
Externí odkaz:
https://doaj.org/article/0ffd7cab8459488f9e4bc0fff6039101
Autor:
L. Dembele, X. Ang, M. Chavchich, G. M. C. Bonamy, J. J. Selva, M. Yi-Xiu Lim, C. Bodenreider, B. K. S. Yeung, F. Nosten, B. M. Russell, M. D. Edstein, J. Straimer, D. A. Fidock, T. T. Diagana, P. Bifani
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Malaria control and elimination are threatened by the emergence and spread of resistance to artemisinin-based combination therapies (ACTs). Experimental evidence suggests that when an artemisinin (ART)-sensitive (K13 wild-type) Plasmodium fa
Externí odkaz:
https://doaj.org/article/99f7a3c6162945b384400f88d2d8584f
Autor:
Annemarie Voorberg-van der Wel, Guglielmo Roma, Devendra Kumar Gupta, Sven Schuierer, Florian Nigsch, Walter Carbone, Anne-Marie Zeeman, Boon Heng Lee, Sam O Hofman, Bart W Faber, Judith Knehr, Erica Pasini, Bernd Kinzel, Pablo Bifani, Ghislain M C Bonamy, Tewis Bouwmeester, Clemens H M Kocken, Thierry Tidiane Diagana
Publikováno v:
eLife, Vol 6 (2017)
Plasmodium liver hypnozoites, which cause disease relapse, are widely considered to be the last barrier towards malaria eradication. The biology of this quiescent form of the parasite is poorly understood which hinders drug discovery. We report a com
Externí odkaz:
https://doaj.org/article/fe01f6ed27ac49e38c3c509c4167af68
Autor:
Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu
Publikováno v:
Science Translational Medicine. 13
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound library and identified candidate chemical inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88cb7c9fc29a66acc799682b5292b913
https://doi.org/10.1126/scitranslmed.abb2181
https://doi.org/10.1126/scitranslmed.abb2181
Autor:
Xavier, Pivot, M A, Georgievich, Volodymyr, Shamrai, Giorgi, Dzagnidze, Hwoei Fen, Soo Hoo, Viriya, Kaewkangsadan, Fausto, Petrelli, Cristian, Villanueva, Lipatov O, Nikolaevich, Jocelyn, Hii, Jamie, Kim, Sumita, Pradhan, Litha, Jaison, Peggy, Feyaerts, Leonard, Kaufman, Marie-Paule, Derde, Ghislain M C, Bonamy, Filip, Deforce, David G, Cox
Publikováno v:
JAMA Oncol
The drug HD201 is a biosimilar candidate for breast cancer treatment as the reference trastuzumab.To compare the efficacy of HD201 with referent trastuzumab.This randomized clinical trial (TROIKA) included 502 women with ERBB2-positive early breast c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e1e9f56fc5d7bd8b6a17250261ba24
https://doi.org/10.1001/jamaoncol.2021.8171
https://doi.org/10.1001/jamaoncol.2021.8171
Autor:
Sungeun Kim, Anna Dubrovska, Richard J Salamone, John R Walker, Kathryn B Grandinetti, Ghislain M C Bonamy, Anthony P Orth, Jimmy Elliott, Diana Graus Porta, Carlos Garcia-Echeverria, Venkateshwar A Reddy
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e51671 (2013)
Emerging evidence suggests that some cancers contain a population of stem-like TICs (tumor-initiating cells) and eliminating TICs may offer a new strategy to develop successful anti-cancer therapies. As molecular mechanisms underlying the maintenance
Externí odkaz:
https://doaj.org/article/afc46a5f03ad4a36ab847a73399cac56
Autor:
Alex Chao, Boon Heng Lee, Kah Fei Wan, David Beer, Peter Gedeck, Thierry T. Diagana, Jeremy J. Selva, Bin Zou, Ujjini H. Manjunatha, Ghislain M. C. Bonamy
Publikováno v:
ACS Infectious Diseases. 4:635-645
Cryptosporidiosis is a diarrheal disease predominantly caused by Cryptosporidium parvum ( Cp) and Cryptosporidium hominis ( Ch), apicomplexan parasites which infect the intestinal epithelial cells of their human hosts. The only approved drug for cryp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3ddd4502b82cabe3c01150538fcfbb
https://doi.org/10.1021/acsinfecdis.7b00247
https://doi.org/10.1021/acsinfecdis.7b00247
Autor:
Chia Min Lee, Kah Fei Wan, Ralph Riedl, Marco Janoschke, Ghislain M. C. Bonamy, Tewis Bouwmeester, Olaf Galuba, Hongping Dong, Philippe Mathys, Tim Schuhmann, David Estoppey, Martin Spiess, Carsten Russ, Dominic Hoepfner, Ireos Filipuzzi, Boon Heng Lee, Gregory McAllister, Thomas Aust
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 451-460 (2017)
Summary: Flavivirus infections by Zika and dengue virus impose a significant global healthcare threat with no US Food and Drug Administration (FDA)-approved vaccination or specific antiviral treatment available. Here, we present the discovery of an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9885d103c2d40bab02db3f2a1caea162
http://www.sciencedirect.com/science/article/pii/S2211124717304485
http://www.sciencedirect.com/science/article/pii/S2211124717304485
Autor:
Hongping Dong, Bryan K. S. Yeung, Ratna Karuna, Bin Zou, Trixie Wagner, Hui-Quan Yeo, Cyrille Kounde, Oliver Simon, Kah Fei Wan, Qing-Yin Wang, Ghislain M. C. Bonamy, Fumiaki Yokokawa, Ina Dix
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1385-1389
A series of 2-oxopiperazine derivatives were designed from the pyrrolopiperazinone cell-based screening hit 4 as a dengue virus inhibitor. Systematic investigation of the structure-activity relationship (SAR) around the piperazinone ring led to the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada04bec55172ef37cc6806daf8ac826
https://doi.org/10.1016/j.bmcl.2017.02.005
https://doi.org/10.1016/j.bmcl.2017.02.005