Zobrazeno 1 - 10
of 112
pro vyhledávání: '"C. Boese"'
Autor:
Austin C. Boese, Jung Seok Hwang, Isabelle Young, Courteney M. Malin, Vanessa Avalos, JiHoon Kang, Sumin Kang
Publikováno v:
ImmunoMedicine, Vol 2, Iss 2, Pp n/a-n/a (2022)
Abstract Immune checkpoint inhibitors (ICIs) have improved the clinical management of some cancer cases, yet patients still fail to respond to immunotherapy. Dysregulated metabolism is a common feature of many cancers, and metabolites are known to mo
Externí odkaz:
https://doaj.org/article/7c4bf02c06ef456f813d9feedd26fd63
Autor:
Chaoyun Pan, JiHoon Kang, Jung Seok Hwang, Jie Li, Austin C. Boese, Xu Wang, Likun Yang, Titus J. Boggon, Georgia Z. Chen, Nabil F. Saba, Dong M. Shin, Kelly R. Magliocca, Lingtao Jin, Sumin Kang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Glucocorticoid receptor (GR) agonists - used in the treatment of solid malignant tumors to reduce inflammation - could potentially affect the anti-tumor activity of chemotherapy. Here, the authors identify a mechanism of cisplatin resistance observed
Externí odkaz:
https://doaj.org/article/a8ee4777304348e7a36af27f053dd05c
Autor:
Austin C. Boese, Sumin Kang
Publikováno v:
Redox Biology, Vol 42, Iss , Pp 101870- (2021)
Cancer cells display abnormal metabolic activity as a result of activated oncogenes and loss of tumor suppressor genes. The Warburg Effect is a common metabolic feature of cancer that involves a preference for aerobic glycolysis over oxidative phosph
Externí odkaz:
https://doaj.org/article/b505e7810f81495cb56bf81800f8ddf7
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-17 (2018)
Abstract Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading cause of death and disability. Cl
Externí odkaz:
https://doaj.org/article/736dff92e02741a68fa36e746c92b230
Autor:
JiHoon Kang, Jaemoo Chun, Jung Seok Hwang, Chaoyun Pan, Jie Li, Austin C. Boese, Isabelle Young, Courteney M. Malin, Yibin Kang, Don L. Gibbons, Gabriel Sica, Haian Fu, Suresh S. Ramalingam, Lingtao Jin, Sumin Kang
Publikováno v:
Cell reports. 41(11)
The cancer metastasis process involves dysregulated oncogenic kinase signaling, but how this orchestrates metabolic networks and signal cascades to promote metastasis is largely unclear. Here we report that inhibition of glutamate dehydrogenase 1 (GD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b031dc14c2d13a94b46d26963e60a2
https://pubmed.ncbi.nlm.nih.gov/36516759
https://pubmed.ncbi.nlm.nih.gov/36516759
Autor:
Lingtao Jin, Georgia Z. Chen, Chaoyun Pan, Xu Wang, Sumin Kang, Jung Seok Hwang, Li-Kun Yang, Dong M. Shin, JiHoon Kang, Titus J. Boggon, Jie Li, Nabil F. Saba, Austin C. Boese, Kelly R. Magliocca
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Agonists of glucocorticoid receptor (GR) are frequently given to cancer patients with platinum-containing chemotherapy to reduce inflammation, but how GR influences tumor growth in response to platinum-based chemotherapy such as cisplatin through inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe0d50f27d5fcf41aeb7a31ab5ba16a
https://doi.org/10.1038/s41467-021-24845-8
https://doi.org/10.1038/s41467-021-24845-8
Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation
Autor:
Dan Li, Sagar Lonial, Lina Song, Sumin Kang, Kelly R. Magliocca, Anna Umano, Zhuo Georgia Chen, Dong M. Shin, Jaemoo Chun, Austin C. Boese, Jie Li, Nabil F. Saba, JiHoon Kang, Taofeek K. Owonikoko, Chaoyun Pan, Lingtao Jin, Yunhan Jiang
Publikováno v:
Journal of Clinical Investigation. 129:4110-4123
Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of cisplatin resistance in human cancers. However, the molecular mechanism regulating MAST1 levels in cisplatin-resistant tumors is unknown. Through a proteomics screen, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8121302ec1fbe0d148347555a76a2171
https://doi.org/10.1172/jci125963
https://doi.org/10.1172/jci125963
Autor:
Sumin Kang, Austin C. Boese
Publikováno v:
Anoikis ISBN: 9783030738549
Extracellular matrix (ECM) attachment is crucial to prevent programmed death in many epithelial and endothelial cell types. Normally, cells that disengage from the ECM are eliminated via a specific programmed cell death mechanism known as anoikis. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1458e8d8bea467af47b3224de2cb277a
https://doi.org/10.1007/978-3-030-73856-3_1
https://doi.org/10.1007/978-3-030-73856-3_1
Autor:
Marcia C L, Pereira, Austin C, Boese, Rabi, Murad, Jun, Yin, Milton H, Hamblin, Jean-Pyo, Lee
Publikováno v:
Experimental Neurology. 352:114042
Current stem cell therapies for Parkinson's disease (PD) focus on a neurorestorative approach that aims to repair the CNS during the symptomatic phase. However, the pleiotropic and supportive effects of human neural stem cells (hNSCs) may make them e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fb5355fcc225834bc1aebd1ca0b5be
https://doi.org/10.1016/j.expneurol.2022.114042
https://doi.org/10.1016/j.expneurol.2022.114042
Publikováno v:
Exp Neurol
Introduction Clinically, significant stroke injury results from ischemia-reperfusion (IR), which induces a deleterious biphasic opening of the blood-brain barrier (BBB). Tissue plasminogen activator (tPA) remains the sole pharmacological agent to tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb32eb3dff415c6188d59af0de4da36
https://pubmed.ncbi.nlm.nih.gov/32147438
https://pubmed.ncbi.nlm.nih.gov/32147438