Zobrazeno 1 - 10
of 67
pro vyhledávání: '"C. Bleul"'
Autor:
Jeremy B. Swann, Annelies Weyn, Daisuke Nagakubo, Conrad C. Bleul, Atsushi Toyoda, Christiane Happe, Nikolai Netuschil, Isabell Hess, Annette Haas-Assenbaum, Yoshihito Taniguchi, Michael Schorpp, Thomas Boehm
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1184-1197 (2014)
The thymus is a lymphoid organ unique to vertebrates, and it provides a unique microenvironment that facilitates the differentiation of immature hematopoietic precursors into mature T cells. We subjected the evolutionary trajectory of the thymic micr
Externí odkaz:
https://doaj.org/article/ca82771736a049f9915b6f7d602cd395
Akademický článek
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Autor:
John E. Wagner, Claudio G. Brunstein, Conrad C. Bleul, Jakub Tolar, Julie Jones, Bruce R. Blazar, Chap T. Le, David H. McKenna, Darin Sumstad, Michael P. Cooke, Todd E. DeFor, Anthony E. Boitano
Publikováno v:
Cell Stem Cell. 18:144-155
Clinical application of umbilical cord blood (UCB) as a source of hematopoietic stem cells for transplantation is limited by low CD34+ cell dose, increased risk of graft failure and slow hematopoietic recovery. While the cell dose limitation is parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a0591f3cf97cd6502abb3dc9b52133
https://doi.org/10.1016/j.stem.2015.10.004
https://doi.org/10.1016/j.stem.2015.10.004
Autor:
Wolfgang Hueber, Norbert Blödorn-Schlicht, Robert Matheson, David M. Lee, Georg Stingl, Rodion A Kunynetz, John H. Tu, Ulrike Sommer, Thomas Falk, Robert Bissonnette, Thomas Peters, Conrad C. Bleul, Wolfgang Bauer, Marc Bourcier, David Gratton, Les Rosoph, Kristian Reich, Ernst Kriehuber, Martin Schumacher, Frank Kolbinger, Yves Poulin, Janeen M Salter, Grazyna Wieczorek, Kim A. Papp
Publikováno v:
Experimental Dermatology
The response of psoriasis to antibodies targeting the interleukin (IL)-23/IL-17A pathway suggests a prominent role of T-helper type-17 (Th17) cells in this disease. We examined the clinical and immunological response patterns of 100 subjects with mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f383111f7f44223d472dfa4939100af4
https://doi.org/10.1111/exd.12710
https://doi.org/10.1111/exd.12710
Autor:
Anthony E. Boitano, Conrad C. Bleul, Claudio G. Brunstein, John E. Wagner, David H. McKenna, Darin Sumstad, Bastiano Sanna, Michael P. Cooke, Todd E. DeFor
Publikováno v:
Biology of Blood and Marrow Transplantation. 24:S24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf1c95067f7bc768b799fd0b964e9639
https://doi.org/10.1016/j.bbmt.2017.12.016
https://doi.org/10.1016/j.bbmt.2017.12.016
Publikováno v:
Journal of Immunology
Thymopoiesis strictly depends on proper differentiation of the thymic epithelial anlage. Differentiation of thymic epithelial cells (TECs) is controlled by the Foxn1 transcription factor. The in vivo signals initiating and maintaining Foxn1 expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10845c66534aa96c6e67fe39fdf1239
https://doi.org/10.4049/jimmunol.181.8.5272
https://doi.org/10.4049/jimmunol.181.8.5272
Publikováno v:
The Journal of Experimental Medicine
T cell development in the thymus depends on continuous colonization by hematopoietic precursors. Several distinct T cell precursors have been identified, but whether one or several independent precursor cell types maintain thymopoiesis is unclear. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cfede080adc58c7976c3ed614451ed
http://europepmc.org/articles/PMC2373849
http://europepmc.org/articles/PMC2373849
Publikováno v:
Proceedings of the National Academy of Sciences. 104:8421-8426
The location of leukocytes in different microenvironments is intimately connected to their function and, in the case of leukocyte precursors, to the executed differentiation and maturation program. Leukocyte migration within lymphoid organs has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe93fc981dadf0fb634bab55b532fd8
https://doi.org/10.1073/pnas.0608274104
https://doi.org/10.1073/pnas.0608274104
Autor:
Thomas Boehm, Conrad C. Bleul
Publikováno v:
Nature Immunology
Lymphoid organs are important regulators of lymphocyte development and immune responses. During vertebrate evolution, primary lymphoid organs appeared earlier than secondary lymphoid organs. Among the sites of primary lymphopoiesis during evolution a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea37dcc22348fb5bea250649d5ae8c8
https://doi.org/10.1038/ni1435
https://doi.org/10.1038/ni1435
Publikováno v:
The Journal of Immunology. 178:858-868
T lymphocytes develop in the thymus from hemopoietic precursors that commit to the T cell lineage under the influence of Notch signals. In this study, we show by single cell analyses that the most immature hemopoietic precursors in the adult mouse th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455607a278045bed73ca958dfc39dbb5
https://doi.org/10.4049/jimmunol.178.2.858
https://doi.org/10.4049/jimmunol.178.2.858