Zobrazeno 1 - 10
of 500
pro vyhledávání: '"C. Blake Gilks"'
Autor:
Maryam Asadi-Aghbolaghi, Amirali Darbandsari, Allen Zhang, Alberto Contreras-Sanz, Jeffrey Boschman, Pouya Ahmadvand, Martin Köbel, David Farnell, David G. Huntsman, Andrew Churg, Peter C. Black, Gang Wang, C. Blake Gilks, Hossein Farahani, Ali Bashashati
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-18 (2024)
Abstract Investigation of histopathology slides by pathologists is an indispensable component of the routine diagnosis of cancer. Artificial intelligence (AI) has the potential to enhance diagnostic accuracy, improve efficiency, and patient outcomes
Externí odkaz:
https://doaj.org/article/72c28cf50b92406fb499cf977e8ae969
Autor:
Amirali Darbandsari, Hossein Farahani, Maryam Asadi, Matthew Wiens, Dawn Cochrane, Ali Khajegili Mirabadi, Amy Jamieson, David Farnell, Pouya Ahmadvand, Maxwell Douglas, Samuel Leung, Purang Abolmaesumi, Steven J. M. Jones, Aline Talhouk, Stefan Kommoss, C. Blake Gilks, David G. Huntsman, Naveena Singh, Jessica N. McAlpine, Ali Bashashati
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Endometrial cancer (EC) has four molecular subtypes with strong prognostic value and therapeutic implications. The most common subtype (NSMP; No Specific Molecular Profile) is assigned after exclusion of the defining features of the other th
Externí odkaz:
https://doaj.org/article/662df4c2a8c74fef89e91218b2ae148f
Autor:
Ramin Nakhli, Katherine Rich, Allen Zhang, Amirali Darbandsari, Elahe Shenasa, Amir Hadjifaradji, Sidney Thiessen, Katy Milne, Steven J. M. Jones, Jessica N. McAlpine, Brad H. Nelson, C. Blake Gilks, Hossein Farahani, Ali Bashashati
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract In clinical oncology, many diagnostic tasks rely on the identification of cells in histopathology images. While supervised machine learning techniques necessitate the need for labels, providing manual cell annotations is time-consuming. In t
Externí odkaz:
https://doaj.org/article/d5b7664a19394eb596fe78c48482395e
Autor:
Julyanne Brassard, Michael R. Hughes, Pamela Dean, Diana Canals Hernaez, Shelby Thornton, Allyson C. Banville, Julian Smazynski, Mary Warren, Kevin Zhang, Katy Milne, C. Blake Gilks, Anne-Marie Mes-Masson, David G. Huntsman, Brad H. Nelson, Calvin D. Roskelley, Kelly M. McNagny
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionTargeted-immunotherapies such as antibody-drug conjugates (ADC), chimeric antigen receptor (CAR) T cells or bispecific T-cell engagers (eg, BiTE®) all aim to improve cancer treatment by directly targeting cancer cells while sparing healt
Externí odkaz:
https://doaj.org/article/63a8aa00a3774a79b38d00326168392f
Autor:
Felix K. F. Kommoss, Anne-Sophie Chong, Anne-Laure Chong, Elke Pfaff, David T. W. Jones, Laura S. Hiemcke-Jiwa, Lennart A. Kester, Uta Flucke, Manfred Gessler, Daniel Schrimpf, Felix Sahm, Blaise A. Clarke, Colin J. R. Stewart, Yemin Wang, C. Blake Gilks, Friedrich Kommoss, David G. Huntsman, Ulrich Schüller, Christian Koelsche, W. Glenn McCluggage, Andreas von Deimling, William D. Foulkes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
DICER1 syndrome is associated with a predisposition to multiple tumor types. Here, the authors identify and characterize 3 molecular subgroups of mesenchymal tumors with DICER1 mutations.
Externí odkaz:
https://doaj.org/article/a05486ab7360425590af6bdea112612d
Autor:
Dane Cheasley, Marta Llaurado Fernandez, Martin Köbel, Hannah Kim, Amy Dawson, Joshua Hoenisch, Madison Bittner, Derek S. Chiu, Aline Talhouk, C. Blake Gilks, Madawa W. Jayawardana, Kathleen I. Pishas, Anne-Marie Mes-Masson, Diane Provencher, Abhimanyu Nigam, Neville F. Hacker, Kylie L. Gorringe, Ian G. Campbell, Mark S. Carey
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-8 (2022)
Abstract Hormone receptor expression is a characteristic of low-grade serous ovarian carcinoma (LGSOC). Studies investigating estrogen receptor (ER) and progesterone receptor (PR) expression levels suggest its prognostic and predictive significance,
Externí odkaz:
https://doaj.org/article/c07926245a9a4565975b9f415dbd3ba0
Autor:
Anne Sophie V.M. Van den Heerik, Natalja T. Ter Haar, Lisa Vermij, Jan J. Jobsen, Mariel Brinkhuis, Suzan M. Roothaan, Alicia Leon-Castillo, Gitte Ortoft, Estrid Hogdall, Claus Hogdall, Tom Van Wezel, Ludy C.H.W. Lutgens, Marie A.D. Haverkort, Jas Khattra, Jessica N. McAlpine, Carien L. Creutzberg, Vincent T.H.B.M. Smit, C. Blake Gilks, Nanda Horeweg, Tjalling Bosse
Publikováno v:
JCO Global Oncology, Vol , Iss 9 (2023)
PURPOSEDetection of 11 pathogenic variants in the POLE gene in endometrial cancer (EC) is critically important to identify women with a good prognosis and reduce overtreatment. Currently, POLE status is determined by DNA sequencing, which can be expe
Externí odkaz:
https://doaj.org/article/fba14e34232b4bcea6998f7113f0afe7
Autor:
Karama Asleh, Gian Luca Negri, Sandra E. Spencer Miko, Shane Colborne, Christopher S. Hughes, Xiu Q. Wang, Dongxia Gao, C. Blake Gilks, Stephen K. L. Chia, Torsten O. Nielsen, Gregg B. Morin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Protein level information enables the identification of potential biomarkers and therapeutic targets for breast cancer. Here, the authors perform proteomic analysis of 2 cohorts of breast cancer surgical specimens and identify distinct subtypes, immu
Externí odkaz:
https://doaj.org/article/721684907354410998201013bf23a946
Autor:
Gillian E. Hanley, Jessica N. McAlpine, Dianne Miller, David Huntsman, Kasmintan A. Schrader, C. Blake Gilks, Gillian Mitchell
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-8 (2018)
Abstract Background Identifying female carriers of BRCA1 and BRCA2 mutations is imperative for prevention of ovarian cancer and breast cancer. There are five major histologic subtypes of ovarian cancer and high grade serous cancer (the most common) i
Externí odkaz:
https://doaj.org/article/08c98e376bf946d69896665f29f9cc15
Publikováno v:
Gynecologic Oncology Reports, Vol 20, Iss C, Pp 140-141 (2017)
Externí odkaz:
https://doaj.org/article/97ade7a1b662482c824f0ffbcfe40407