Zobrazeno 1 - 10
of 231
pro vyhledávání: '"C. Bellingham"'
Autor:
H. Cannaby, M. D. Palmer, T. Howard, L. Bricheno, D. Calvert, J. Krijnen, R. Wood, J. Tinker, C. Bunney, J. Harle, A. Saulter, C. O'Neill, C. Bellingham, J. Lowe
Publikováno v:
Ocean Science, Vol 12, Iss 3, Pp 613-632 (2016)
Singapore is an island state with considerable population, industries, commerce and transport located in coastal areas at elevations less than 2 m making it vulnerable to sea level rise. Mitigation against future inundation events requires a quantita
Externí odkaz:
https://doaj.org/article/374ef756f28a436d981f3be82267af79
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106614- (2024)
Perineuronal nets (PNNs) are extracellular matrix structures that surround excitable neurons and their proximal dendrites. PNNs play an important role in neuroprotection against oxidative stress. Oxidative stress within motor neurons can act as a tri
Externí odkaz:
https://doaj.org/article/9b188baf16d24c7cb9c3cb629ea735bb
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
In amyotrophic lateral sclerosis (ALS) postmortem tissue and the SOD1 mouse model at mid-disease, death of hypoglossal motor neurons (XII MNs) is evident. These XII MNs innervate the intrinsic and extrinsic tongue muscles, and despite their importanc
Externí odkaz:
https://doaj.org/article/200989ceacc844b09f2bd1a936ff92f2
Autor:
Lei Qian, Oliver Rawashdeh, Leda Kasas, Michael R. Milne, Nicholas Garner, Kornraviya Sankorrakul, Nicola Marks, Matthew W. Dean, Pu Reum Kim, Aanchal Sharma, Mark C. Bellingham, Elizabeth J. Coulson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Sleep-disordered breathing is a risk factor for Alzheimer’s disease. Here the authors use mesopontine tegmentum lesion to model sleep disordered breathing in a mouse model of Alzheimer’s disease, and find that some features of the Alzheimer’s d
Externí odkaz:
https://doaj.org/article/22de7d61738d47849857fbf106da033e
Autor:
Monika Gaik, Marija Kojic, Megan R Stegeman, Tülay Öncü‐Öner, Anna Kościelniak, Alun Jones, Ahmed Mohamed, Pak Yan Stefanie Chau, Sazia Sharmin, Andrzej Chramiec‐Głąbik, Paulina Indyka, Michał Rawski, Anna Biela, Dominika Dobosz, Amanda Millar, Vann Chau, Aycan Ünalp, Michael Piper, Mark C Bellingham, Evan E Eichler, Deborah A Nickerson, Handan Güleryüz, Nour El Hana Abbassi, Konrad Jazgar, Melissa J Davis, Saadet Mercimek‐Andrews, Sultan Cingöz, Brandon J Wainwright, Sebastian Glatt
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 7, Pp 1-21 (2022)
Abstract The highly conserved Elongator complex is a translational regulator that plays a critical role in neurodevelopment, neurological diseases, and brain tumors. Numerous clinically relevant variants have been reported in the catalytic Elp123 sub
Externí odkaz:
https://doaj.org/article/f87fbaa46ca24838baab46a1729467a8
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7965 (2022)
Normal development and function of the central nervous system involves a balance between excitatory and inhibitory neurotransmission. Activity of both excitatory and inhibitory neurons is modulated by inhibitory signalling of the GABAergic and glycin
Externí odkaz:
https://doaj.org/article/02dbf85f2e894f94b4a67599f87fe5e7
Autor:
Jonu Pradhan, Mark C. Bellingham
Publikováno v:
Brain Sciences, Vol 11, Iss 5, p 549 (2021)
Amyotrophic lateral sclerosis (ALS) is a progressive neuromotor disease characterized by the loss of upper and lower motor neurons (MNs), resulting in muscle paralysis and death. Early cortical hyper-excitability is a common pathological process obse
Externí odkaz:
https://doaj.org/article/d9e984dd9bb54ee3978c212f63f45740
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Motoneurons develop extensive dendritic trees for receiving excitatory and inhibitory synaptic inputs to perform a variety of complex motor tasks. At birth, the somatodendritic domains of mouse hypoglossal and lumbar motoneurons have dense filopodia
Externí odkaz:
https://doaj.org/article/1ceb063d6e4243cab8daac48551939ca
Publikováno v:
The Anatomical Record. 304:1562-1581
The total motor neuron (MN) somato-dendritic surface area is correlated with motor unit type. MNs with smaller surface areas innervate slow (S) and fast fatigue-resistant (FR) motor units, while MNs with larger surface areas innervate fast fatigue-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e57307d5765a7e5c8fa73d3213e3c80
https://doi.org/10.1002/ar.24542
https://doi.org/10.1002/ar.24542
Publikováno v:
The Anatomical Record. 303:1455-1471
The motor neuron (MN) soma surface area is correlated with motor unit type. Larger MNs innervate fast fatigue-intermediate (FInt) or fast-fatiguable (FF) muscle fibers in type FInt and FF motor units, respectively. Smaller MNs innervate slow-twitch f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11df2f6623beecef101f67229c0ac8e0
https://doi.org/10.1002/ar.24255
https://doi.org/10.1002/ar.24255