Zobrazeno 1 - 10
of 2 888
pro vyhledávání: '"C. Baguley"'
Autor:
Khanh B. Tran, Sharada Kolekar, Anower Jabed, Patrick Jaynes, Jen-Hsing Shih, Qian Wang, Jack U. Flanagan, Gordon W. Rewcastle, Bruce C. Baguley, Peter R. Shepherd
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background The PI 3-kinase (PI3K) pathway has been implicated as a target for melanoma therapy. Methods Given the high degree of genetic heterogeneity in melanoma, we sought to understand the breadth of variation in PI3K signalling in the la
Externí odkaz:
https://doaj.org/article/d29833ad5d6e40eeb218477ffd82bea6
Autor:
Dean C. Singleton, Anne-Lise Dechaume, Pamela M. Murray, William P. Katt, Bruce C. Baguley, Euphemia Y. Leung
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Glutamine serves as an important nutrient with many cancer types displaying glutamine dependence. Following cellular uptake glutamine is converted to glutamate in a reaction catalysed by mitochondrial glutaminase. This glutamate h
Externí odkaz:
https://doaj.org/article/610f5156d2c24e1e8f92504261190da4
Autor:
Wenli Zhang, Caibin Li, Ya Jin, Xinyue Liu, Zhiyu Wang, John P. Shaw, Bruce C. Baguley, Zimei Wu, Jianping Liu
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 611-622 (2018)
To improve drug retention in carriers for amphiphilic asulacrine (ASL), a novel active loading method using micelle gradient was developed to fabricate the ASL-loaded multiseed liposomes (ASL-ML). The empty ML were prepared by hydrating a thin film w
Externí odkaz:
https://doaj.org/article/80e2e24bdb214463864680afeba008bb
Autor:
Carole Ferraro-Peyret, Marjan E. Askarian-Amiri, Debina Sarkar, Wayne R. Joseph, Herah Hansji, Bruce C. Baguley, Euphemia Y. Leung
Publikováno v:
Sci, Vol 3, Iss 2, p 26 (2021)
Endoplasmic reticulum (ENR) stress perturbs cell homeostasis and induces the unfolded protein response (UPR). In breast cancer, this process is activated by oestrogen deprivation and is associated with tamoxifen resistance. We present evidence that t
Externí odkaz:
https://doaj.org/article/8253ed9cae2f4b4ba4579bf94d976640
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Norman E. Sharpless, Sharon L. Campbell, Bruce C. Baguley, Michael J. Miley, Daniel C. Zedek, David B. Darr, George P. Souroullas, William R. Jeck, Brit L. Martin, Kailing Fu, Kelly S. Clark, James E. Gillahan, Meriam A. Waqas, Minh V. Huynh, Wenjin Liu, Christin E. Burd
Figure S1. Generation of the LSL-N-RasQ61R allele. Figure S2. Conditional expression of N-Ras mutants does not alter melanocyte morphology. Figure S3. In both the heterozygous and homozygous state, NRasG12D fails to induce melanoma formation. Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5c3e3adfbf56270fa607f7d8df27f8
https://doi.org/10.1158/2159-8290.22530242.v1
https://doi.org/10.1158/2159-8290.22530242.v1
Autor:
Norman E. Sharpless, Sharon L. Campbell, Bruce C. Baguley, Michael J. Miley, Daniel C. Zedek, David B. Darr, George P. Souroullas, William R. Jeck, Brit L. Martin, Kailing Fu, Kelly S. Clark, James E. Gillahan, Meriam A. Waqas, Minh V. Huynh, Wenjin Liu, Christin E. Burd
NRAS mutation at codons 12, 13, or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an NrasQ61R knock-in allele to similarly designed KrasG12D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b07545ea77a4bfaa05fa90bb50b2e69
https://doi.org/10.1158/2159-8290.c.6546137.v1
https://doi.org/10.1158/2159-8290.c.6546137.v1
Publikováno v:
Molecules, Vol 26, Iss 3, p 552 (2021)
Amsacrine, an anticancer drug first synthesised in 1970 by Professor Cain and colleagues, showed excellent preclinical activity and underwent clinical trial in 1978 under the auspices of the US National Cancer Institute, showing activity against acut
Externí odkaz:
https://doaj.org/article/3a345b1c41cb4573a9b93c642f5f8b07
Autor:
Euphemia Y. Leung, Marjan E. Askarian-Amiri, Dean C. Singleton, Carole Ferraro-Peyret, Wayne R. Joseph, Graeme J. Finlay, Reuben J. Broom, Purvi M. Kakadia, Stefan K. Bohlander, Elaine Marshall, Bruce C. Baguley
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Background: Most human breast cancer cell lines currently in use were developed and are cultured under ambient (21%) oxygen conditions. While this is convenient in practical terms, higher ambient oxygen could increase oxygen radical production, poten
Externí odkaz:
https://doaj.org/article/8fe0484eac0b4e098934e7c44d3dace8
Autor:
Euphemia Y. Leung, Marjan E. Askarian-Amiri, Debina Sarkar, Carole Ferraro-Peyret, Wayne R. Joseph, Graeme J. Finlay, Bruce C. Baguley
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
IntroductionEndocrine therapy of breast cancer, which either deprives cancer tissue of estrogen or prevents estrogen pathway signaling, is the most common treatment after surgery and radiotherapy. We have previously shown for the estrogen-responsive
Externí odkaz:
https://doaj.org/article/c26f77e84ada42639446a2fb5d3822e5