Výsledky vyhledávání - "C. B. Pickett"

Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK

Autor: T, Nguyen, H C, Huang, C B, Pickett

Publikováno v: The Journal of biological chemistry. 275(20)

The antioxidant response element (ARE) mediates the transcriptional activation of many genes encoding phase II drug-metabolizing enzymes in response to oxidative stress. Recent studies using knockout mice suggest that NF-E2-related factor 2 (Nrf2), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::725163a71fcf3745d3483ca5756503b4
https://pubmed.ncbi.nlm.nih.gov/10747902

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The rat quinone reductase antioxidant response element. Identification of the nucleotide sequence required for basal and inducible activity and detection of antioxidant response element-binding proteins in hepatoma and non-hepatoma cell lines

Autor: L V, Favreau, C B, Pickett

Publikováno v: The Journal of biological chemistry. 270(41)

The antioxidant response element (ARE) found in the 5'-flanking region of the rat quinone reductase gene has been further characterized by mutational and deletion analysis. The results indicate that the 31-base pair ARE, which contains a 13-base pair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb3a902843a6ec16a9708719ee7bac24
https://pubmed.ncbi.nlm.nih.gov/7592662

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Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

Autor: T, Nguyen, T H, Rushmore, C B, Pickett

Publikováno v: The Journal of biological chemistry. 269(18)

Using transfection and gel retardation assays, we have characterized further the antioxidant response element (ARE) found in the 5'-flanking region of the rat glutathione S-transferase Ya subunit gene. The ARE core sequence (5'-GTGACAAAGC-3') is suff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de0e0468721fb85a730a9aefb3c476a0
https://pubmed.ncbi.nlm.nih.gov/8175801

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Regulation of Expression of Rat Liver Glutathione S-Transferases: Xenobiotic and Antioxidant Induction of the Ya Subunit Gene

Autor: C. B. Pickett, T. H. Rushmore, A. Y. H. Lu

Publikováno v: Handbook of Experimental Pharmacology ISBN: 9783642784316

The glutathione S-transferases (GSTs) are a family of proteins that conjugate glutathione, via the sulfur atom of cysteine, to various electrophiles (Boyland and Chasseaud 1969; Chasseaud 1979; Jacoby 1978; Mannervik 1985; Mannervik and Danielson 198

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b608db500298e6dc7ea56bee266cb2d
https://doi.org/10.1007/978-3-642-78429-3_3

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Site-directed mutagenesis of glutathione S-transferase YaYa. Mapping the glutathione-binding site

Autor: R W, Wang, D J, Newton, A R, Johnson, C B, Pickett, A Y, Lu

Publikováno v: The Journal of biological chemistry. 268(32)

Previous studies from our laboratory have shown that aspartic acid 101 plays an important role in glutathione interaction to rat glutathione S-transferase YaYa, while tyrosine 9 is directly involved in catalysis. Based on the available structural inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b0285118768f2fb914427a954dd0262
https://pubmed.ncbi.nlm.nih.gov/8226940

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Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Characterization of a DNA-protein interaction at the antioxidant responsive element and induction by 12-O-tetradecanoylphorbol 13-acetate

Autor: L V, Favreau, C B, Pickett

Publikováno v: The Journal of biological chemistry. 268(26)

We have previously identified a novel xenobiotic responsive element, which has been termed the antioxidant responsive element (ARE), in the 5'-flanking region of the rat quinone reductase gene (Favreau, L. V., and Pickett, C. B. (1991) J. Biol. Chem.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2645f590ea5303f3095af73304c3524e
https://pubmed.ncbi.nlm.nih.gov/8396148

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Glutathione S-transferases, structure, regulation, and therapeutic implications

Autor: T H, Rushmore, C B, Pickett

Publikováno v: The Journal of biological chemistry. 268(16)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ff91ff948ed837722ce0eb1c877de3b
https://pubmed.ncbi.nlm.nih.gov/8505281

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Site-directed mutagenesis of glutathione S-transferase YaYa. Important roles of tyrosine 9 and aspartic acid 101 in catalysis

Autor: R W, Wang, D J, Newton, S E, Huskey, B M, McKeever, C B, Pickett, A Y, Lu

Publikováno v: The Journal of biological chemistry. 267(28)

The roles of tyrosine 9 and aspartic acid 101 in the catalytic mechanism of rat glutathione S-transferase YaYa were studied by site-directed mutagenesis. Replacement of tyrosine 9 with phenylalanine (Y9F), threonine (Y9T), histidine (Y9H), or valine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::729181f6f8b522d46cba47ca5040b296
https://pubmed.ncbi.nlm.nih.gov/1400302

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