Zobrazeno 1 - 10
of 37
pro vyhledávání: '"C. B. Nash"'
Autor:
G. R. Breese, C. B. Nash
Publikováno v:
British Journal of Pharmacology and Chemotherapy. 25:621-630
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 12(3)
Three dose levels of pyridostigmine (0.5, 2, and 5 mg/kg) were given iv to dogs anesthetized with sodium pentobarbital. Hemodynamic measurements made were cardiac output, blood pressure, left ventricular dP/dT, and heart rate. Pulmonary function data
Publikováno v:
Journal of cardiovascular pharmacology. 3(1)
This study examined the role of cardiac beta-adrenergic receptors and cardiac sympathetic and vagal nerves in the cardiotoxicity of 3-beta-0-(4-amino-4,6-dideoxy-beta-D-glucopyranosyl) digitoxigenin hydrochloride (ASI-254). Vagally intact dogs receiv
Autor:
R W, Caldwell, C B, Nash
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 235(3)
The ability of digoxin and a 4-aminocardenolide, ASI-222, to alter atrioventricular nodal refractory period (AVRP) was determined as a function of the maximum subarrhythmic dose (MSAD) in the dog anesthetized with morphine-pentobarbital. ASI-222, a h
Autor:
D W, Korte, C B, Nash
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 197(2)
The effects of quinidine and propranolol, singly and in combination, on certain electrophysiological responses were studied in open-chest dogs. Parameters measured were the diastolic threshold, conduction time, excitability and functional refractory
Publikováno v:
Oral Presentations.
The antagonism of platelet function has been suggested as a mode of action for sudden death prophylaxis by sulfinpyrazone (S) and salicylates (A). To evaluate an antiarrhythmic means for such action, 5.0 to 20.0 mg/Kg A or S was administered i.v. to
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 227(2)
The effects of ASI-222 HCl and digoxin on cardiac contractile force, dP/dt, heart rate and mean blood pressure in the dog were evaluated following i.v. administration. Additional studies were performed on isolated, electrically driven rabbit atria wi
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 215(1)
In anesthetized dogs, structure activity relationships among three cardiotonic compounds were determined by comparing the cardiovascular effects of digotoxigenin (the genin) to digitoxigenin-galactose (a genin-neutral sugar combination) and to digito
Autor:
R W, Caldwell, C B, Nash
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 197(1)
ASI-222,3beta-O-(4-amino-4,6-dideoxy-beta-d-galactopyranosyl) digitoxigenin, is a semi-synthetic cardiac glycoside patterned after a natural glycoside obtained from Cambodia. Effects of ASI-222 on contractile force in the isolated rabbit atria, cardi