Zobrazeno 1 - 10
of 5 725
pro vyhledávání: '"C. Arnold"'
Publikováno v:
Geoscientific Model Development, Vol 17, Pp 4017-4029 (2024)
Machine learning (ML) algorithms can be used in Earth system models (ESMs) to emulate sub-grid-scale processes. Due to the statistical nature of ML algorithms and the high complexity of ESMs, these hybrid ML ESMs require careful validation. Simulatio
Externí odkaz:
https://doaj.org/article/4c49c89c98584c3d8fb0bd5f8c5c9374
Autor:
Leonie Hartl, Marieke S. ten Brink, Hella L. Aberson, Jan Koster, Danny A. Zwijnenburg, JanWillem Duitman, Maarten F. Bijlsma, C. Arnold Spek
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9449 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a low 5-year survival rate of only 13%. Despite intense research efforts, PDAC remains insufficiently understood. In part, this is attributed to opposing effects of key players being un
Externí odkaz:
https://doaj.org/article/c3b6f80a508d47debd1643a94dbe33ab
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and severe disease characterized by excessive matrix deposition in the lungs. Macrophages play crucial roles in maintaining lung homeostasis but are also central in the
Externí odkaz:
https://doaj.org/article/c5b7c0e436bb4f81b2d2c86b9d92d80e
Autor:
Cansu Tekin, Brendon P. Scicluna, Sophie C. Lodestijn, Kun Shi, Maarten F. Bijlsma, C. Arnold Spek
Publikováno v:
Molecular Oncology, Vol 15, Iss 11, Pp 3091-3108 (2021)
Pancreatic acinar cells have high plasticity and can transdifferentiate into ductal‐like cells. This acinar‐to‐ductal metaplasia (ADM) contributes to tissue maintenance but may also contribute to the premalignant transformation that can eventua
Externí odkaz:
https://doaj.org/article/655bec2113474b9fb2695cc8e9d4dd14
Autor:
Etienne J. Slapak, Mouad el Mandili, Marieke S. Ten Brink, Alexander Kros, Maarten F. Bijlsma, C. Arnold Spek
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10704 (2023)
Pancreatic adenocarcinoma (PDAC) remains largely refractory to chemotherapeutic treatment regimens and, consequently, has the worst survival rate of all cancers. The low efficacy of current treatments results largely from toxicity-dependent dose limi
Externí odkaz:
https://doaj.org/article/0580b70b0fd144ed8c3748e1bfb836bd
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a grim disease with high mortality rates. Increased macrophage influx in PDAC is a common hallmark and associated with poor prognosis. Macrophages have high cellular plasticity, which can
Externí odkaz:
https://doaj.org/article/73d1e99142ce41bc93e5c3bcd4de4616
Autor:
Leonie Hartl, Joris J. T. H. Roelofs, Frederike Dijk, Maarten F. Bijlsma, JanWillem Duitman, C. Arnold Spek
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1537 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a poor clinical prognosis and unsatisfactory treatment options. We previously found that the transcription factor CCAAT/Enhancer-Binding Protein Delta (C/EBPδ) is lowly expressed in PD
Externí odkaz:
https://doaj.org/article/fb34ce85fd9541798e7888cb6e5de024
Autor:
N. Russell, C. Wilhelm-Benartzi, J. Othman, R. Dillon, N. Potter, J. Jovanovic, A. Gilkes, L. M. Batten, J. Canham, E. L. Hinson, P. Kottaridis, J. Cavenagh, C. Arnold, M. Dennis, S. Knapper
Publikováno v:
HemaSphere, Vol 6, Pp 27-28 (2022)
Externí odkaz:
https://doaj.org/article/640a2b90737542798c43eb953871ad0e
Autor:
N. Russell, C. Wilhelm-Benartzi, S. Knapper, L. Batten, J Canham, E. Hinson, U. Malthe Overgaard, J. Othman, R. Dillon, P. Mehta, P. Kottaridis, J. Cavenagh, C. Hemmaway, C. Arnold, M. Dennis
Publikováno v:
HemaSphere, Vol 6, Pp 29-30 (2022)
Externí odkaz:
https://doaj.org/article/eae52e8b0eaa408bb51120d045efd2bd
Autor:
K. Huber, S. Garg, L. He, A. Pouya, C. Rohde, C. Lüchtenborg, C. Arnold, J. Zaugg, S. Raffel, C. Müller-Tidow, B. Brügger, C. Pabst
Publikováno v:
HemaSphere, Vol 6, Pp 310-311 (2022)
Externí odkaz:
https://doaj.org/article/62caac2217da4945ae5a614f683df7a8