Zobrazeno 1 - 10
of 65
pro vyhledávání: '"C. Arnò"'
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges due to the inadequacy of existing chemotherapeutics, which often result in toxicity-dependent dose limitations and premature cessation of therapy. Targeted delivery of t
Externí odkaz:
https://doaj.org/article/21affa4ad5fa4ab093c47cbbe4cb4702
Publikováno v:
Geoscientific Model Development, Vol 17, Pp 4017-4029 (2024)
Machine learning (ML) algorithms can be used in Earth system models (ESMs) to emulate sub-grid-scale processes. Due to the statistical nature of ML algorithms and the high complexity of ESMs, these hybrid ML ESMs require careful validation. Simulatio
Externí odkaz:
https://doaj.org/article/4c49c89c98584c3d8fb0bd5f8c5c9374
Publikováno v:
Animal, Vol 18, Iss 4, Pp 101120- (2024)
In stabled horses, several behaviours are considered to be important indicators of the state of welfare at the individual level: stereotypies, aggressive behaviours towards humans and the “withdrawn”, alert, sternal, lateral and observation postu
Externí odkaz:
https://doaj.org/article/dc78f4e61b014989916367f9c173c50b
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Biogeosciences, Vol 19, Pp 5617-5631 (2022)
Oceanic bacterial communities process a major fraction of marine organic carbon. A substantial portion of this carbon transformation occurs in the mesopelagic zone, and a further fraction fuels bacteria in the bathypelagic zone. However, the capabili
Externí odkaz:
https://doaj.org/article/909d7d28575a414e86bd683e05eb0d17
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and severe disease characterized by excessive matrix deposition in the lungs. Macrophages play crucial roles in maintaining lung homeostasis but are also central in the
Externí odkaz:
https://doaj.org/article/c5b7c0e436bb4f81b2d2c86b9d92d80e
Autor:
S. Cohen, A. Guenolé, I. Lazar, A. Marnef, T. Clouaire, D. V. Vernekar, N. Puget, V. Rocher, C. Arnould, M. Aguirrebengoa, M. Genais, N. Firmin, R. A. Shamanna, R. Mourad, V. A. Bohr, V. Borde, G. Legube
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
DNA Double Strand breaks in transcriptionally active loci (TC-DSBs) undergo a dedicated repair pathway. Here, the authors show that excessive RNA:DNA hybrid accumulation at TC-DSBs elicits POLD3/BLM-dependent DNA synthesis that induces cell toxicity.
Externí odkaz:
https://doaj.org/article/95d14e8284ac407d9d00afb87ef19d23
Autor:
Cansu Tekin, Brendon P. Scicluna, Sophie C. Lodestijn, Kun Shi, Maarten F. Bijlsma, C. Arnold Spek
Publikováno v:
Molecular Oncology, Vol 15, Iss 11, Pp 3091-3108 (2021)
Pancreatic acinar cells have high plasticity and can transdifferentiate into ductal‐like cells. This acinar‐to‐ductal metaplasia (ADM) contributes to tissue maintenance but may also contribute to the premalignant transformation that can eventua
Externí odkaz:
https://doaj.org/article/655bec2113474b9fb2695cc8e9d4dd14
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a grim disease with high mortality rates. Increased macrophage influx in PDAC is a common hallmark and associated with poor prognosis. Macrophages have high cellular plasticity, which can
Externí odkaz:
https://doaj.org/article/73d1e99142ce41bc93e5c3bcd4de4616