Zobrazeno 1 - 10
of 99
pro vyhledávání: '"C. Alves da Costa"'
Autor:
C. Alves da Costa, Frédéric Checler
Publikováno v:
Neurodegenerative Diseases. 13:118-121
Parkin is responsible for most autosomal juvenile recessive cases of Parkinson's disease (PD). Besides its well-characterized function as ubiquitin ligase, we previously established that parkin could repress p53 at the transcriptional level. Interest
Autor:
Y. Marie, Jérôme Honnorat, Eric Duplan, Julien Viotti, J.-Y. Delattre, Thomas Goiran, C Caillava, J Condat, C Giordano, Frédéric Checler, C. Alves da Costa, Ahmed Idbaih
Publikováno v:
Oncogene. 33:1764-1775
Gliomas represent the most frequent form of primary brain tumors in adults, the prognosis of which remains extremely poor. Inactivating mutations on the tumor suppressor TP53 were proposed as a key etiological trigger of glioma development. p53 has b
Autor:
Gilles Pagès, Frédéric Checler, Peter Heutink, Jie Shen, Sabine Scarzello, Matthew S. Goldberg, Charlotte Druon, Guillaume Robert, Patrick Auberger, Sébastien Grosso, Emilie Giaime, Jacques Pouysségur, C. Alves da Costa, Claire Sunyach
Publikováno v:
Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2009, epub ahead of print. ⟨10.1038/cdd.2009.116⟩
Cell Death and Differentiation, 17(1), 158-169. Nature Publishing Group
Giaime, E, Sunyach, C, Druon, C, Scarzello, S, Robert, G, Grosso, S, Auberger, P, Goldberg, M S, Shen, J, Heutink, P, Pouyssegur, J, Pages, G, Checler, F & da Costa, C A 2010, ' Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6 ', Cell Death and Differentiation, vol. 17, no. 1, pp. 158-169 . https://doi.org/10.1038/cdd.2009.116
Cell Death and Differentiation, Nature Publishing Group, 2009, epub ahead of print. ⟨10.1038/cdd.2009.116⟩
Cell Death and Differentiation, 17(1), 158-169. Nature Publishing Group
Giaime, E, Sunyach, C, Druon, C, Scarzello, S, Robert, G, Grosso, S, Auberger, P, Goldberg, M S, Shen, J, Heutink, P, Pouyssegur, J, Pages, G, Checler, F & da Costa, C A 2010, ' Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6 ', Cell Death and Differentiation, vol. 17, no. 1, pp. 158-169 . https://doi.org/10.1038/cdd.2009.116
International audience; DJ-1 was recently identified as a gene product responsible for a subset of familial Parkinson's disease (PD). The mechanisms by which mutations in DJ-1 alter its function and account for PD-related pathology remained largely u
Autor:
Raphaëlle Pardossi-Piquard, Frédéric Checler, C. Alves da Costa, Julie Dunys, P. St. George-Hyslop, Gang Yu
Publikováno v:
Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 2006, 97, pp.1052-1056
Journal of Neurochemistry, Wiley, 2006, 97, pp.1052-1056
We recently demonstrated that the presenilin-dependent gamma-secretase complex regulates the expression and activity of neprilysin, one of the main enzymes that degrade the amyloid beta-peptide (Abeta) which accumulates in Alzheimer's disease. Here,
Publikováno v:
Revista Dental Press de Ortodontia e Ortopedia Facial, Vol 9, Iss 4, Pp 86-97 (2004)
Este artigo compreende a segunda parte da análise facial frontal em fotografias padronizadas. Fizeram parte da amostra estudada 40 mulheres, com idade média de 22 anos, leucodermas, com faces agradáveis, Classe I de Angle, sem história prévia de
Publikováno v:
Revista Dental Press de Ortodontia e Ortopedia Facial, Vol 9, Iss 3, Pp 47-58 (2004)
Considerando a importância da análise facial frontal no diagnóstico, esse trabalho propõem-se a apresentar uma análise facial frontal em fotografias padronizadas, em repouso e durante o sorriso, que possa auxiliar no diagnóstico e planejamento
Autor:
C. Alves da Costa
Publikováno v:
Current Molecular Medicine. 3:17-24
Alpha-synuclein is a recently discovered protein that was first identified as the major non amyloid component of senile plaques, the cerebral lesion likely responsible for Alzheimer's disease. The role of alpha-synuclein in another brain disease name
Publikováno v:
Journal of Neurochemistry. 83:1208-1214
We examined the influence of cellular prion protein (PrPc) in the control of cell death in stably transfected HEK293 cell line and in the PrPc-inducible Rov9 cells. PrPc expression in stably transfected HEK293 human cells did not modify basal apoptot
Autor:
Frédéric Bihel, Olivier Pourquié, Agnès Petit, C. Alves da Costa, Frédéric Checler, Jean Louis Kraus
Publikováno v:
Nature Cell Biology. 3:507-511
We have designed new non-peptidic potential inhibitors of gamma-secretase and examined their ability to prevent production of amyloid-beta 40 (Abeta40) and Abeta42 by human cells expressing wild-type and Swedish-mutant beta-amyloid precursor protein
Publikováno v:
Neuroscience Letters. 285:79-82
Synucleins are neuronal proteins detectable in the neuropathological lesions of several cerebral disorders. Thus, alpha-synuclein immunoreactivity is found in Lewy bodies, the histopathological hallmark of sporadic Parkinson disease-affected brains.